| 释义 |
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{{Infobox_gene}}Cytoskeleton-associated protein 2 is a protein that in humans is encoded by the CKAP2 gene.[1][2]Human CKAP2 gene, the cDNA of which is known as LB1, is a cytoskeleton-associated protein involved in mitotic progression. Its high transcriptional activity has been observed in the testes, thymus, and diffuse B-cell lymphomas. The gene codes for a protein of 683 residues, which lacks a homology to known amino acid sequences. On evidence of immunofluorescence analysis, the CKAP2 product is a cytoplasmic protein associated with cytoskeletal fibrils. The CKAP2 gene is in chromosome 13q14. Rearrangements of this region result in various tumors. Thus deletions have been detected in multiple myeloma, prostate cancer, head-and-neck squamous-cell carcinoma, B-cell prolymphocytic leukemia, non-Hodgkin lymphoma, and in more than half cases of B-cell chronic lymphocytic leukemia. References1. ^{{cite journal | vauthors = Maouche-Chretien L, Deleu N, Badoual C, Fraissignes P, Berger R, Gaulard P, Romeo PH, Leroy-Viard K | title = Identification of a novel cDNA, encoding a cytoskeletal associated protein, differentially expressed in diffuse large B cell lymphomas | journal = Oncogene | volume = 17 | issue = 10 | pages = 1245–51 |date=Oct 1998 | pmid = 9771967 | pmc = | doi = 10.1038/sj.onc.1202048 }}
2. ^{{cite web | title = Entrez Gene: CKAP2 cytoskeleton associated protein 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26586| accessdate = }}
Alternative titles: TUMOR- AND MICROTUBLE-ASSOCIATED PROTEIN; TMAP, LB1 External linksFurther reading{{refbegin | 2}}- {{cite journal | vauthors=Eichmuller S, Usener D, Dummer R |title=Serological detection of cutaneous T-cell lymphoma-associated antigens |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 2 |pages= 629–34 |year= 2001 |pmid= 11149944 |doi= 10.1073/pnas.021386498 | pmc=14639 |display-authors=etal}}
- {{cite journal | vauthors=Wiemann S, Weil B, Wellenreuther R |title=Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs |journal=Genome Res. |volume=11 |issue= 3 |pages= 422–35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.GR1547R | pmc=311072 |display-authors=etal}}
- {{cite journal | vauthors=Udina IG, Baranova AV, Kompaniĭtsev AA, Sulimova GE |title=[Evolutionarily-conserved gene CKAP2,located in region 13q14.3 of the human genome, is frequently rearranged in various tumors] |journal=Genetika |volume=37 |issue= 1 |pages= 120–3 |year= 2001 |pmid= 11234418 |doi= }}
- {{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
- {{cite journal | vauthors=Rakhmanaliev ER, Klimov EA, Kompaniĭtsev AA, Sulimova GE |title=[The structure of the human oncogenesis-associated CKAP2 (LB1) gene] |journal=Mol. Biol. (Mosk.) |volume=36 |issue= 6 |pages= 985–9 |year= 2003 |pmid= 12500535 |doi= }}
- {{cite journal | vauthors=Bae CD, Sung YS, Jeon SM |title=Up-regulation of cytoskeletal-associated protein 2 in primary human gastric adenocarcinomas |journal=J. Cancer Res. Clin. Oncol. |volume=129 |issue= 11 |pages= 621–30 |year= 2004 |pmid= 12942315 |doi= 10.1007/s00432-003-0484-0 |display-authors=etal}}
- {{cite journal | vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal}}
- {{cite journal | vauthors=Dunham A, Matthews LH, Burton J |title=The DNA sequence and analysis of human chromosome 13 |journal=Nature |volume=428 |issue= 6982 |pages= 522–8 |year= 2004 |pmid= 15057823 |doi= 10.1038/nature02379 | pmc=2665288 |display-authors=etal}}
- {{cite journal | vauthors=Jin J, Smith FD, Stark C |title=Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization |journal=Curr. Biol. |volume=14 |issue= 16 |pages= 1436–50 |year= 2004 |pmid= 15324660 |doi= 10.1016/j.cub.2004.07.051 |display-authors=etal}}
- {{cite journal | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
- {{cite journal | vauthors=Nousiainen M, Silljé HH, Sauer G |title=Phosphoproteome analysis of the human mitotic spindle |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=103 |issue= 14 |pages= 5391–6 |year= 2006 |pmid= 16565220 |doi= 10.1073/pnas.0507066103 | pmc=1459365 |display-authors=etal}}
- {{cite journal | vauthors=Jeon SM, Choi B, Hong KU |title=A cytoskeleton-associated protein, TMAP/CKAP2, is involved in the proliferation of human foreskin fibroblasts |journal=Biochem. Biophys. Res. Commun. |volume=348 |issue= 1 |pages= 222–8 |year= 2006 |pmid= 16876122 |doi= 10.1016/j.bbrc.2006.07.046 |display-authors=etal}}
- {{cite journal | vauthors=Hong KU, Park YS, Seong YS |title=Functional Importance of the Anaphase-Promoting Complex-Cdh1-Mediated Degradation of TMAP/CKAP2 in Regulation of Spindle Function and Cytokinesis |journal=Mol. Cell. Biol. |volume=27 |issue= 10 |pages= 3667–81 |year= 2007 |pmid= 17339342 |doi= 10.1128/MCB.01386-06 | pmc=1900002 |display-authors=etal}}
- {{cite journal | vauthors=Seki A, Fang G |title=CKAP2 is a spindle-associated protein degraded by APC/C-Cdh1 during mitotic exit |journal=J. Biol. Chem. |volume=282 |issue= 20 |pages= 15103–13 |year= 2007 |pmid= 17376772 |doi= 10.1074/jbc.M701688200 }}
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