1. Interactions

2. References

3. External links

4. Further reading

Cytoskeleton-associated protein 5 is a microtubule-associated protein that in humans is encoded by the CKAP5 gene.^[1][2][3] It is the homolog of the Xenopus protein XMAP215^[4] and is also known as ch-Tog.

It has at least two distinct roles in spindle formation: it protects kinetochore microtubules from depolymerization by MCAK (KIF2C), and ch-Tog plays an essential role in centrosomal microtubule assembly, a function independent of MCAK activity.^[5]

Interactions

CKAP5 has been shown to interact with TACC1.^[6][7]

References

External links

• {{UCSC gene info|CKAP5}}

Further reading

• {{cite journal | vauthors = Basto R, Gergely F, Draviam VM, Ohkura H, Liley K, Raff JW | title = Hsp90 is required to localise cyclin B and Msps/ch-TOG to the mitotic spindle in Drosophila and humans | journal = J. Cell Sci. | volume = 120 | issue = Pt 7 | pages = 1278–87 | year = 2007 | pmid = 17376965 | doi = 10.1242/jcs.000604 }}
• {{cite journal | vauthors = Kosturko LD, Maggipinto MJ, D'Sa C, Carson JH, Barbarese E | title = The microtubule-associated protein tumor overexpressed gene binds to the RNA trafficking protein heterogeneous nuclear ribonucleoprotein A2 | journal = Mol. Biol. Cell | volume = 16 | issue = 4 | pages = 1938–47 | year = 2005 | pmid = 15703215 | pmc = 1073673 | doi = 10.1091/mbc.E04-08-0709 }}
• {{cite journal | vauthors = Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP | title = Large-scale characterization of HeLa cell nuclear phosphoproteins | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 101 | issue = 33 | pages = 12130–5 | year = 2004 | pmid = 15302935 | pmc = 514446 | doi = 10.1073/pnas.0404720101 }}
• {{cite journal | vauthors = Cassimeris L, Morabito J | title = TOGp, the human homolog of XMAP215/Dis1, is required for centrosome integrity, spindle pole organization, and bipolar spindle assembly | journal = Mol. Biol. Cell | volume = 15 | issue = 4 | pages = 1580–90 | year = 2004 | pmid = 14718566 | pmc = 379257 | doi = 10.1091/mbc.E03-07-0544 }}
• {{cite journal | vauthors = Conte N, Delaval B, Ginestier C, Ferrand A, Isnardon D, Larroque C, Prigent C, Séraphin B, Jacquemier J, Birnbaum D | title = TACC1-chTOG-Aurora A protein complex in breast cancer | journal = Oncogene | volume = 22 | issue = 50 | pages = 8102–16 | year = 2003 | pmid = 14603251 | doi = 10.1038/sj.onc.1206972 }}
• {{cite journal | vauthors = Gergely F, Draviam VM, Raff JW | title = The ch-TOG/XMAP215 protein is essential for spindle pole organization in human somatic cells | journal = Genes Dev. | volume = 17 | issue = 3 | pages = 336–41 | year = 2003 | pmid = 12569123 | pmc = 195983 | doi = 10.1101/gad.245603 }}
• {{cite journal | vauthors = Nakayama M, Kikuno R, Ohara O | title = Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs | journal = Genome Res. | volume = 12 | issue = 11 | pages = 1773–84 | year = 2002 | pmid = 12421765 | pmc = 187542 | doi = 10.1101/gr.406902 }}
• {{cite journal | vauthors = Lauffart B, Howell SJ, Tasch JE, Cowell JK, Still IH | title = Interaction of the transforming acidic coiled-coil 1 (TACC1) protein with ch-TOG and GAS41/NuBI1 suggests multiple TACC1-containing protein complexes in human cells | journal = Biochem. J. | volume = 363 | issue = Pt 1 | pages = 195–200 | year = 2002 | pmid = 11903063 | pmc = 1222467 | doi = 10.1042/0264-6021:3630195 }}
• {{cite journal | vauthors = Bonaldo MF, Lennon G, Soares MB | title = Normalization and subtraction: two approaches to facilitate gene discovery | journal = Genome Res. | volume = 6 | issue = 9 | pages = 791–806 | year = 1996 | pmid = 8889548 | doi = 10.1101/gr.6.9.791 }}
• {{cite journal | vauthors = Nakamura S, Grigoriev I, Nogi T, Hamaji T, Cassimeris L, Mimori-Kiyosue Y | title = Dissecting the nanoscale distributions and functions of microtubule-end-binding proteins EB1 and ch-TOG in interphase HeLa cells | journal = PLoS ONE | volume = 7 | issue = 12 | pages = e51442 | year = 2012 | pmid = 23251535 | doi = 10.1371/journal.pone.0051442 | pmc=3520847}}
• {{cite journal | vauthors = Zanic M, Widlund PO, Hyman AA, Howard J | title = Synergy between XMAP215 and EB1 increases microtubule growth rates to physiological levels | journal = Nat. Cell Biol. | volume = 15 | issue = 6 | pages = 688–93 | year = 2013 | pmid = 23666085 | doi = 10.1038/ncb2744 }}

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