“Clark's level”的意思、由来-开放百科全书

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Clark's level

释义

References
External links

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Clark's level is a staging system, used in conjunction with Breslow's depth, which describes the level of anatomical invasion of the melanoma in the skin. It was developed by Wallace H. Clark Jr. at Harvard University and Massachusetts General Hospital in the 1960s.

Five anatomical levels are recognized, and higher levels have worsening prognostic implications. These levels are:

Level 1: Melanoma confined to the epidermis (melanoma in situ)
Level 2: Invasion into the papillary dermis
Level 3: Invasion to the junction of the papillary and reticular dermis
Level 4: Invasion into the reticular dermis
Level 5: Invasion into the subcutaneous fat.

Clark's level was the primary factor in earlier AJCC staging schemae for melanoma. {{Citation needed|date=March 2009}} However, with further study, it has been shown that Clark's level has a lower predictive value, is less reproducible, and is more operator-dependent as compared with Breslow's depth.{{Citation needed|date=March 2009}} Thus, in the current (as of 2010) AJCC staging system, Clark's level has prognostic significance only in patients with thin (Breslow depth <1 mm) melanomas.^[1]

References

1. ^{{cite journal |pmid=11504744 |year=2001 |last1=Balch |first1=CM |last2=Soong |first2=SJ |last3=Gershenwald |first3=JE |last4=Thompson |first4=JF |last5=Reintgen |first5=DS |last6=Cascinelli |first6=N |last7=Urist |first7=M |last8=McMasters |first8=KM |last9=Ross |first9=MI |last10=Kirkwood |first10=J. M. |last11=Atkins |first11=M. B. |last12=Thompson |first12=J. A. |last13=Coit |first13=D. G. |last14=Byrd |first14=D |last15=Desmond |first15=R |last16=Zhang |first16=Y |last17=Liu |first17=P. Y. |last18=Lyman |first18=G. H. |last19=Morabito |first19=A |title=Prognostic factors analysis of 17,600 melanoma patients: Validation of the American Joint Committee on Cancer melanoma staging system |volume=19 |issue=16 |pages=3622–34 |journal=Journal of Clinical Oncology|display-authors=8 }}

External links

[https://web.archive.org/web/20050505032329/http://training.seer.cancer.gov/module_staging_cancer/unit03_sec04_part05_melanoma.html Melanoma Staging Systems]. National Cancer Institute. A resource on Clark's levels and Breslow's depth.
Original article from Breslow. Cancer res, 1969.

4 : Histopathology|Melanocytic nevi and neoplasms|Dermatologic terminology|Cancer staging

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