| 词条 | Clazakizumab |
| 释义 |
| type = mab | mab_type = mab | source = zu | target = IL6 | image = | alt = | caption = | tradename = | Drugs.com = | MedlinePlus = | pregnancy_AU = | pregnancy_US = | pregnancy_category= | legal_AU = | legal_CA = | legal_UK = | legal_US = | legal_status = investigational | routes_of_administration = infusion | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion = | CAS_number = 1236278-28-6 | ATCvet = | ATC_prefix = none | ATC_suffix = | PubChem = | ChemSpiderID = none | DrugBank = | KEGG = D10312 | C=6426 | H=9972 | N=1724 | O=2032 | S=42 | molecular_weight = 145.2 kg/mol | synonyms = ALD518, BMS-945429 }}Clazakizumab (formerly ALD518 and BMS-945429), an investigational drug, is a aglycosylated, humanized rabbit monoclonal antibody against interleukin-6.[1] Clazakizumab was developed by Bristol Myers Squib and Alder Biopharmaceuticals. A preliminary randomized, double-blind, placebo-controlled, phase 2 dose-ranging study of clazakizumab in psoriatic arthritis patients, funded by the manufacturer, suggested that clazakizumab may be an effective treatment option for musculoskeletal aspects of psoriatic arthritis; however, the antibody lacked a dose-response effect.[2] See also
References1. ^{{cite book|editor1-link=Stefan Dübel, Janice M. Reichert (eds)|title=Handbook of Therapeutic Antibodies, Volume 2|date=2007|publisher=Wiley Blackwell|page=987|url=https://books.google.com/books?id=svHsBQAAQBAJ&pg=PA987&lpg=PA987&dq=Clazakizumab,+BMS-945429+ALD518&source=bl&ots=OSkfdXWflh&sig=SDM6MUhRVekTcRVaQ6SgemQgXAw&hl=en&sa=X&ved=0ahUKEwjW6a-ipdnRAhUpxlQKHUHrCMwQ6AEIPTAG#v=onepage&q=Clazakizumab%2C%20BMS-945429%20ALD518&f=false|accessdate=January 23, 2017}} {{Monoclonals for immune system}}{{Interleukin receptor modulators}}2. ^{{cite journal|vauthors=Mease PJ, Gottlieb AB|display-authors=etal|title=The efficacy and safety of clazakizumab, an anti-interleukin-6 monoclonal antibody, in a phase IIb study of adults with active psoriatic arthritis.|journal=Arthritis Rheumatol|date=September 2016|volume=68|issue=9|pages=2163–73|doi=10.1002/art.39700}} 3 : Bristol-Myers Squibb|Antibodies|Experimental drugs |
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