| 释义 |
- See also
- References
- Further reading
- External links
{{Infobox_gene}}Chloride channel accessory 4, also known as CLCA4, is a protein which in humans CLCA4 gene. The protein encoded by this gene is a chloride channel.[1] Protein structure prediction methods suggest the N-terminal region of CLCA4 protein is a zinc metalloprotease, and the protein is not an ion channel per se.[2]See alsoReferences1. ^{{cite journal | vauthors = Agnel M, Vermat T, Culouscou JM | title = Identification of three novel members of the calcium-dependent chloride channel (CaCC) family predominantly expressed in the digestive tract and trachea | journal = FEBS Lett. | volume = 455 | issue = 3 | pages = 295–301 |date=July 1999 | pmid = 10437792 | doi = 10.1016/S0014-5793(99)00891-1 | url = }}
2. ^{{cite journal | vauthors=Pawłowski K, Lepistö M, Meinander N |title=Novel conserved hydrolase domain in the CLCA family of alleged calcium-activated chloride channels. |journal=Proteins |volume=63 |issue= 3 |pages= 424–39 |year= 2006 |pmid= 16470849|doi= 10.1002/prot.20887|display-authors=etal}}
Further reading{{refbegin | 2}}- {{cite journal |vauthors=Liu QH, Williams DA, McManus C |title=HIV-1 gp120 and chemokines activate ion channels in primary macrophages through CCR5 and CXCR4 stimulation. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 9 |pages= 4832–7 |year= 2000 |pmid= 10758170 |doi= 10.1073/pnas.090521697 |pmc=18318 |display-authors=etal}}
- {{cite journal |vauthors=Ritzka M, Stanke F, Jansen S |title=The CLCA gene locus as a modulator of the gastrointestinal basic defect in cystic fibrosis. |journal=Hum. Genet. |volume=115 |issue= 6 |pages= 483–91 |year= 2004 |pmid= 15490240 |doi= 10.1007/s00439-004-1190-y |display-authors=etal}}
- {{cite journal |vauthors=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1996 |pmid= 8889548 |doi=10.1101/gr.6.9.791 }}
- {{cite journal |vauthors=Clark HF, Gurney AL, Abaya E |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003 |pmc=403697 |display-authors=etal}}
- {{cite journal |vauthors=Kimura K, Wakamatsu A, Suzuki Y |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 |pmc=1356129 |display-authors=etal}}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2002 |pmid= 12477932 |doi= 10.1073/pnas.242603899 |pmc=139241 |display-authors=etal}}
- {{cite journal |vauthors=Pauli BU, Abdel-Ghany M, Cheng HC |title=Molecular characteristics and functional diversity of CLCA family members. |journal=Clin. Exp. Pharmacol. Physiol. |volume=27 |issue= 11 |pages= 901–5 |year= 2000 |pmid= 11071307 |doi=10.1046/j.1440-1681.2000.03358.x |display-authors=etal}}
{{refend}}External links- {{MeshName|CLCA3+protein,+human}}
- {{UCSC gene info|CLCA4}}
{{Ion channels|g4}}{{membrane-protein-stub}} 1 : Chloride channels |