“CLC (gene)”的意思、由来-开放百科全书

Lysophospholipases are enzymes that act on biological membranes to regulate the multifunctional lysophospholipids. The protein encoded by this gene is a lysophospholipase expressed in eosinophils and basophils. It hydrolyzes lysophosphatidylcholine to glycerophosphocholine and a free fatty acid. This protein may possess carbohydrate or IgE-binding activities. It is both structurally and functionally related to the galectin family of beta-galactoside binding proteins. It may be associated with inflammation and some myeloid leukemias.^[2]

References

1. ^{{cite journal | vauthors = Mastrianni DM, Eddy RL, Rosenberg HF, Corrette SE, Shows TB, Tenen DG, Ackerman SJ | title = Localization of the human eosinophil Charcot-Leyden crystal protein (lysophospholipase) gene (CLC) to chromosome 19 and the human ribonuclease 2 (eosinophil-derived neurotoxin) and ribonuclease 3 (eosinophil cationic protein) genes (RNS2 and RNS3) to chromosome 14 | journal = Genomics | volume = 13 | issue = 1 | pages = 240–2 |date=Jun 1992 | pmid = 1577491 | pmc = | doi =10.1016/0888-7543(92)90237-M }}
2. ^¹{{cite web | title = Entrez Gene: CLC Charcot-Leyden crystal protein| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1178| accessdate = }}

Further reading

{{cite journal | vauthors=Gleich GJ, Loegering DA, Mann KG, Maldonado JE |title=Comparative properties of the Charcot-Leyden crystal protein and the major basic protein from human eosinophils |journal=J. Clin. Invest. |volume=57 |issue= 3 |pages= 633–40 |year= 1976 |pmid= 942977 |doi=10.1172/JCI108319 | pmc=436696 }}

{{cite journal | vauthors=Golightly LM, Thomas LL, Dvorak AM, Ackerman SJ |title=Charcot-Leyden crystal protein in the degranulation and recovery of activated basophils |journal=J. Leukoc. Biol. |volume=51 |issue= 4 |pages= 386–92 |year= 1992 |pmid= 1373430 |doi= }}

{{cite journal | author=Dvorak AM |title=Ultrastructural localization of Charcot-Leyden crystal protein (lysophospholipase) and peroxidase in macrophages, eosinophils, and extracellular matrix of the skin in the hypereosinophilic syndrome |journal=Lab. Invest. |volume=62 |issue= 5 |pages= 590–607 |year= 1990 |pmid= 2160562 |doi= |name-list-format=vanc| author2=Weller PF | author3=Monahan-Earley RA | display-authors=3 | last4=Letourneau | first4=L | last5=Ackerman | first5=SJ }}

{{cite journal | vauthors=Dvorak AM, Letourneau L, Weller PF, Ackerman SJ |title=Ultrastructural localization of Charcot-Leyden crystal protein (lysophospholipase) to intracytoplasmic crystals in tumor cells of primary solid and papillary epithelial neoplasm of the pancreas |journal=Lab. Invest. |volume=62 |issue= 5 |pages= 608–15 |year= 1990 |pmid= 2160563 |doi= }}

{{cite journal | vauthors=Dvorak AM, Ackerman SJ |title=Ultrastructural localization of the Charcot-Leyden crystal protein (lysophospholipase) to granules and intragranular crystals in mature human basophils |journal=Lab. Invest. |volume=60 |issue= 4 |pages= 557–67 |year= 1989 |pmid= 2709814 |doi=10.1111/1523-1747.ep12703656 }}

{{cite journal | author=Sieker LC |title=Crystallographic characterization of human eosinophil Charcot-Leyden crystals |journal=J. Mol. Biol. |volume=204 |issue= 2 |pages= 489–91 |year= 1989 |pmid= 3221396 |doi=10.1016/0022-2836(88)90590-6 |name-list-format=vanc| author2=Turley S | author3=Le Trong I | display-authors=3 | last4=Stenkamp | first4=R | last5=Weller | first5=P | last6=Ackerman | first6=S }}

{{cite journal | vauthors=Weller PF, Bach D, Austen KF |title=Human eosinophil lysophospholipase: the sole protein component of Charcot-Leyden crystals |journal=J. Immunol. |volume=128 |issue= 3 |pages= 1346–9 |year= 1982 |pmid= 6173432 |doi= }}

{{cite journal | vauthors=Weller PF, Bach DS, Austen KF |title=Biochemical characterization of human eosinophil Charcot-Leyden crystal protein (lysophospholipase) |journal=J. Biol. Chem. |volume=259 |issue= 24 |pages= 15100–5 |year= 1985 |pmid= 6511787 |doi= }}

{{cite journal | author=Gomolin HI |title=Human eosinophil Charcot-Leyden crystal protein: cloning and characterization of a lysophospholipase gene promoter |journal=Blood |volume=82 |issue= 6 |pages= 1868–74 |year= 1993 |pmid= 8400237 |doi= |name-list-format=vanc| author2=Yamaguchi Y | author3=Paulpillai AV | display-authors=3 | last4=Dvorak | first4=LA | last5=Ackerman | first5=SJ | last6=Tenen | first6=DG }}

{{cite journal | author=Ackerman SJ |title=Molecular cloning and characterization of human eosinophil Charcot-Leyden crystal protein (lysophospholipase). Similarities to IgE binding proteins and the S-type animal lectin superfamily |journal=J. Immunol. |volume=150 |issue= 2 |pages= 456–68 |year= 1993 |pmid= 8419478 |doi= |name-list-format=vanc| author2=Corrette SE | author3=Rosenberg HF | display-authors=3 | last4=Bennett | first4=JC | last5=Mastrianni | first5=DM | last6=Nicholson-Weller | first6=A | last7=Weller | first7=PF | last8=Chin | first8=DT | last9=Tenen | first9=DG }}

{{cite journal | author=Leonidas DD |title=Crystal structure of human Charcot-Leyden crystal protein, an eosinophil lysophospholipase, identifies it as a new member of the carbohydrate-binding family of galectins |journal=Structure |volume=3 |issue= 12 |pages= 1379–93 |year= 1996 |pmid= 8747464 |doi=10.1016/S0969-2126(01)00275-1 |name-list-format=vanc| author2=Elbert BL | author3=Zhou Z | display-authors=3 | last4=Leffler | first4=Hakon | last5=Ackerman | first5=Steven J | last6=Acharya | first6=K.Ravi }}

{{cite journal | vauthors=Dyer KD, Handen JS, Rosenberg HF |title=The genomic structure of the human Charcot-Leyden crystal protein gene is analogous to those of the galectin genes |journal=Genomics |volume=40 |issue= 2 |pages= 217–21 |year= 1997 |pmid= 9119387 |doi= 10.1006/geno.1996.4590 |url=https://zenodo.org/record/1229719/files/article.pdf }}

{{cite journal | author=Swaminathan GJ |title=Selective recognition of mannose by the human eosinophil Charcot-Leyden crystal protein (galectin-10): a crystallographic study at 1.8 A resolution |journal=Biochemistry |volume=38 |issue= 42 |pages= 13837–43 |year= 1999 |pmid= 10529229 |doi=10.1021/bi990756e |name-list-format=vanc| author2=Leonidas DD | author3=Savage MP | display-authors=3 | last4=Ackerman | first4=Steven J. | last5=Acharya | first5=K. Ravi }}

{{cite journal | author=Larramendy ML |title=Overexpression of translocation-associated fusion genes of FGFRI, MYC, NPMI, and DEK, but absence of the translocations in acute myeloid leukemia. A microarray analysis |journal=Haematologica |volume=87 |issue= 6 |pages= 569–77 |year= 2003 |pmid= 12031912 |doi= |name-list-format=vanc| author2=Niini T | author3=Elonen E | display-authors=3 | last4=Nagy | first4=B | last5=Ollila | first5=J | last6=Vihinen | first6=M | last7=Knuutila | first7=S }}

{{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |name-list-format=vanc| author2=Feingold EA | author3=Grouse LH | display-authors=3 | last4=Derge | first4=JG | last5=Klausner | first5=RD | last6=Collins | first6=FS | last7=Wagner | first7=L | last8=Shenmen | first8=CM | last9=Schuler | first9=GD }}

{{cite journal | author=Abedin MJ |title=Potential roles of galectins in myeloid differentiation into three different lineages |journal=J. Leukoc. Biol. |volume=73 |issue= 5 |pages= 650–6 |year= 2003 |pmid= 12714580 |doi=10.1189/jlb.0402163 |name-list-format=vanc| author2=Kashio Y | author3=Seki M | display-authors=3 | last4=Nakamura | first4=K | last5=Hirashima | first5=M }}

{{cite journal | author=Grimwood J |title=The DNA sequence and biology of human chromosome 19 |journal=Nature |volume=428 |issue= 6982 |pages= 529–35 |year= 2004 |pmid= 15057824 |doi= 10.1038/nature02399 |name-list-format=vanc| author2=Gordon LA | author3=Olsen A | display-authors=3 | last4=Terry | first4=Astrid | last5=Schmutz | first5=Jeremy | last6=Lamerdin | first6=Jane | last7=Hellsten | first7=Uffe | last8=Goodstein | first8=David | last9=Couronne | first9=Olivier }}

{{cite journal | author=Gerhard DS |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |name-list-format=vanc| author2=Wagner L | author3=Feingold EA | display-authors=3 | last4=Shenmen | first4=CM | last5=Grouse | first5=LH | last6=Schuler | first6=G | last7=Klein | first7=SL | last8=Old | first8=S | last9=Rasooly | first9=R }}

{{cite journal | author=Nielsen K |title=Altered expression of CLC, DSG3, EMP3, S100A2, and SLPI in corneal epithelium from keratoconus patients |journal=Cornea |volume=24 |issue= 6 |pages= 661–8 |year= 2005 |pmid= 16015083 |doi=10.1097/01.ico.0000153556.59407.69 |name-list-format=vanc| author2=Heegaard S | author3=Vorum H | display-authors=3 | last4=Birkenkamp-Demtr??Der | first4=Karin | last5=Ehlers | first5=Niels | last6=Orntoft | first6=Torben Falck }}

See also

References

External links

Further reading