| 释义 |
- Clinical significance
- References
- External links
- Further reading
{{Infobox_gene}}Claudin-18 is a protein that in humans is encoded by the CLDN18 gene.[1] It belongs to the group of claudins. CLDN18 belongs to the large claudin family of proteins, which form tight junction strands in epithelial cells .[1] [supplied by OMIM][2] Clinical significanceIsoform 2 (Claudin 18.2) is abundant in gastric tumors.[3] Experimental antibody IMAB362 targets Claudin 18.2 to help treat gastric cancers.[3] References1. ^{{cite journal | vauthors=Niimi T, Nagashima K, Ward JM |title=claudin-18, a Novel Downstream Target Gene for the T/EBP/NKX2.1 Homeodomain Transcription Factor, Encodes Lung- and Stomach-Specific Isoforms through Alternative Splicing |journal=Mol. Cell. Biol. |volume=21 |issue= 21 |pages= 7380–90 |year= 2001 |pmid= 11585919 |doi= 10.1128/MCB.21.21.7380-7390.2001 | pmc=99911 |display-authors=etal}}
2. ^1 {{cite web | title = Entrez Gene: CLDN18 claudin 18| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51208| accessdate = }}
3. ^1 Antibody Shines in Advanced Gastric Cancer - IMAB362 leads to longer remission, better survival. June 2016
External links- {{UCSC gene info|CLDN18}}
Further reading{{refbegin | 2}}- {{cite journal | vauthors=Kniesel U, Wolburg H |title=Tight junctions of the blood–brain barrier. |journal=Cell. Mol. Neurobiol. |volume=20 |issue= 1 |pages= 57–76 |year= 2000 |pmid= 10690502 |doi=10.1023/A:1006995910836 }}
- {{cite journal | vauthors=Heiskala M, Peterson PA, Yang Y |title=The roles of claudin superfamily proteins in paracellular transport. |journal=Traffic |volume=2 |issue= 2 |pages= 93–8 |year= 2001 |pmid= 11247307 |doi=10.1034/j.1600-0854.2001.020203.x }}
- {{cite journal | vauthors=Tsukita S, Furuse M, Itoh M |title=Multifunctional strands in tight junctions. |journal=Nat. Rev. Mol. Cell Biol. |volume=2 |issue= 4 |pages= 285–93 |year= 2001 |pmid= 11283726 |doi= 10.1038/35067088 }}
- {{cite journal | vauthors=Tsukita S, Furuse M |title=Claudin-based barrier in simple and stratified cellular sheets. |journal=Curr. Opin. Cell Biol. |volume=14 |issue= 5 |pages= 531–6 |year= 2003 |pmid= 12231346 |doi=10.1016/S0955-0674(02)00362-9 }}
- {{cite journal | vauthors=González-Mariscal L, Betanzos A, Nava P, Jaramillo BE |title=Tight junction proteins. |journal=Prog. Biophys. Mol. Biol. |volume=81 |issue= 1 |pages= 1–44 |year= 2003 |pmid= 12475568 |doi=10.1016/S0079-6107(02)00037-8 }}
- {{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
- {{cite journal | vauthors=Clark HF, Gurney AL, Abaya E |title=The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003 | pmc=403697 |display-authors=etal}}
- {{cite journal | vauthors=Oh JH, Yang JO, Hahn Y |title=Transcriptome analysis of human gastric cancer |journal=Mamm. Genome |volume=16 |issue= 12 |pages= 942–54 |year= 2006 |pmid= 16341674 |doi= 10.1007/s00335-005-0075-2 |display-authors=etal}}
- {{cite journal | vauthors=Matsuda Y, Semba S, Ueda J |title=Gastric and intestinal claudin expression at the invasive front of gastric carcinoma |journal=Cancer Sci. |volume=98 |issue= 7 |pages= 1014–9 |year= 2007 |pmid= 17459057 |doi= 10.1111/j.1349-7006.2007.00490.x |display-authors=etal}}
- {{cite journal | vauthors = Liu F, Koval M, Ranganathan S, Fanayan S, Hancock WS, Lundberg EK, Beavis RC, Lane L, Duek P, McQuade L, Kelleher NL, Baker MS | title = A systems proteomics view of the endogenous human claudin protein family | journal = J Proteome Res | date= 2015 | pmid = 26680015 | doi = 10.1021/acs.jproteome.5b00769 | url = https://archive-ouverte.unige.ch/unige:79118/ATTACHMENT01 }}
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