| 释义 |
- References
- External links
- Further reading
{{Infobox_gene}}Claudin-19 is a protein that in humans is encoded by the CLDN19 gene.[1] It belongs to the group of claudins. Claudin-19 has been implicated in magnesium transport.[2][3]Claudins, such as CLDN19, are transmembrane proteins found at tight junctions. Tight junctions form barriers that control the passage of ions and molecules across an epithelial sheet and the movement of proteins and lipids between apical and basolateral domains of epithelial cells (Lee et al., 2006).[supplied by OMIM][4] References1. ^{{cite web | title = Entrez Gene: CLDN19 claudin 19| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=149461| accessdate = }}
2. ^{{Cite journal | last1 = Naeem | first1 = M. | last2 = Hussain | first2 = S. | last3 = Akhtar | first3 = N. | doi = 10.1159/000330854 | title = Mutation in the Tight-Junction Gene Claudin 19 (CLDN19) and Familial Hypomagnesemia, Hypercalciuria, Nephrocalcinosis (FHHNC) and Severe Ocular Disease | journal = American Journal of Nephrology | volume = 34 | issue = 3 | pages = 241–248 | year = 2011 | pmid = 21791920 | pmc = }}
3. ^{{Cite journal | last1 = Konrad | first1 = M. | last2 = Schaller | first2 = A. | last3 = Seelow | first3 = D. | last4 = Pandey | first4 = A. V. | last5 = Waldegger | first5 = S. | last6 = Lesslauer | first6 = A. | last7 = Vitzthum | first7 = H. | last8 = Suzuki | first8 = Y. | last9 = Luk | first9 = J. M. | last10 = Becker | doi = 10.1086/508617 | first10 = C. | last11 = Schlingmann | first11 = K. P. | last12 = Schmid | first12 = M. | last13 = Rodriguez-Soriano | first13 = J. | last14 = Ariceta | first14 = G. | last15 = Cano | first15 = F. | last16 = Enriquez | first16 = R. | last17 = Jüppner | first17 = H. | last18 = Bakkaloglu | first18 = S. A. | last19 = Hediger | first19 = M. A. | last20 = Gallati | first20 = S. | last21 = Neuhauss | first21 = S. C. F. | last22 = Nürnberg | first22 = P. | last23 = Weber | first23 = S. | title = Mutations in the Tight-Junction Gene Claudin 19 (CLDN19) Are Associated with Renal Magnesium Wasting, Renal Failure, and Severe Ocular Involvement | journal = The American Journal of Human Genetics | volume = 79 | issue = 5 | pages = 949–957 | year = 2006 | pmid = 17033971 | pmc =1698561 }}
4. ^{{cite web | title = Entrez Gene: CLDN19 claudin 19| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=149461| accessdate = }}
External links- {{UCSC gene info|CLDN19}}
Further reading{{refbegin | 2}}- {{cite journal | vauthors=Kniesel U, Wolburg H |title=Tight junctions of the blood–brain barrier. |journal=Cell. Mol. Neurobiol. |volume=20 |issue= 1 |pages= 57–76 |year= 2000 |pmid= 10690502 |doi=10.1023/A:1006995910836 }}
- {{cite journal | vauthors=Heiskala M, Peterson PA, Yang Y |title=The roles of claudin superfamily proteins in paracellular transport. |journal=Traffic |volume=2 |issue= 2 |pages= 93–8 |year= 2001 |pmid= 11247307 |doi=10.1034/j.1600-0854.2001.020203.x }}
- {{cite journal | vauthors=Tsukita S, Furuse M, Itoh M |title=Multifunctional strands in tight junctions. |journal=Nat. Rev. Mol. Cell Biol. |volume=2 |issue= 4 |pages= 285–93 |year= 2001 |pmid= 11283726 |doi= 10.1038/35067088 }}
- {{cite journal | vauthors=Tsukita S, Furuse M |title=Claudin-based barrier in simple and stratified cellular sheets. |journal=Curr. Opin. Cell Biol. |volume=14 |issue= 5 |pages= 531–6 |year= 2003 |pmid= 12231346 |doi=10.1016/S0955-0674(02)00362-9 }}
- {{cite journal | vauthors=González-Mariscal L, Betanzos A, Nava P, Jaramillo BE |title=Tight junction proteins. |journal=Prog. Biophys. Mol. Biol. |volume=81 |issue= 1 |pages= 1–44 |year= 2003 |pmid= 12475568 |doi=10.1016/S0079-6107(02)00037-8 }}
- {{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
- {{cite journal | vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal}}
- {{cite journal | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
- {{cite journal | vauthors=Lee NP, Tong MK, Leung PP |title=Kidney claudin-19: localization in distal tubules and collecting ducts and dysregulation in polycystic renal disease. |journal=FEBS Lett. |volume=580 |issue= 3 |pages= 923–31 |year= 2006 |pmid= 16427635 |doi= 10.1016/j.febslet.2006.01.019 |display-authors=etal}}
- {{cite journal | vauthors=Konrad M, Schaller A, Seelow D |title=Mutations in the tight-junction gene claudin 19 (CLDN19) are associated with renal magnesium wasting, renal failure, and severe ocular involvement. |journal=Am. J. Hum. Genet. |volume=79 |issue= 5 |pages= 949–57 |year= 2006 |pmid= 17033971 |doi= 10.1086/508617 | pmc=1698561 |display-authors=etal}}
- {{cite journal | vauthors = Liu F, Koval M, Ranganathan S, Fanayan S, Hancock WS, Lundberg EK, Beavis RC, Lane L, Duek P, McQuade L, Kelleher NL, Baker MS | title = A systems proteomics view of the endogenous human claudin protein family | journal = J Proteome Res | date= 2015 | pmid = 26680015 | doi = 10.1021/acs.jproteome.5b00769 | url = https://archive-ouverte.unige.ch/unige:79118/ATTACHMENT01 }}
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