| 释义 |
- Function
- References
- External links
- Further reading
{{Infobox gene}}Claudin-2 is a protein that in humans is encoded by the CLDN2 gene.[1][2] It belongs to the group of claudins. Members of the claudin protein family, such as CLDN2, are expressed in an organ-specific manner and regulate the tissue-specific physiologic properties of tight junctions (Sakaguchi et al., 2002).[supplied by OMIM][2] Function Claudin-2 is expressed in cation-leaky epithelia such as that of the kidney proximal tubule.[3] Mice that are deficient in claudin-2 have reduced reabsorption of Na+ in the proximal tubule, consistent with a role in paracellular transport. Similar results have been obtained with cultured cells, as overexpression in claudin-2 lacking cells leads to increase of permeability for small cations.[4] Furthermore, claudin-2 has been shown to form paracellular channels for water.[5] References 1. ^{{cite journal | vauthors = Morita K, Furuse M, Fujimoto K, Tsukita S | title = Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands | journal = Proc Natl Acad Sci U S A | volume = 96 | issue = 2 | pages = 511–6 |date=March 1999 | pmid = 9892664 | pmc = 15167 | doi =10.1073/pnas.96.2.511 }}
2. ^1 {{cite web | title = Entrez Gene: CLDN2 claudin 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9075| accessdate = }}
3. ^{{cite journal| last1 = Muto | first1 = S.| last2 = Hata | first2 = M.| last3 = Taniguchi | first3 = J.| last4 = Tsuruoka | first4 = S.| last5 = Moriwaki | first5 = K.| last6 = Saitou | first6 = M.| last7 = Furuse | first7 = K.| last8 = Sasaki | first8 = H.| last9 = Fujimura | first9 = A.| doi = 10.1073/pnas.0912901107| last10 = Imai | first10 = M.| last11 = Kusano | first11 = E.| last12 = Tsukita | first12 = S.| last13 = Furuse | first13 = M.| title = Claudin-2-deficient mice are defective in the leaky and cation-selective paracellular permeability properties of renal proximal tubules| journal = Proceedings of the National Academy of Sciences| volume = 107| issue = 17| pages = 8011–8016| year = 2010| pmid = 20385797| pmc =2867900}}
4. ^{{cite journal|pmid=12432083|year=2002|author1=Amasheh|first1=S|title=Claudin-2 expression induces cation-selective channels in tight junctions of epithelial cells|journal=Journal of Cell Science|volume=115|issue=Pt 24|pages=4969–76|last2=Meiri|first2=N|last3=Gitter|first3=A. H.|last4=Schöneberg|first4=T|last5=Mankertz|first5=J|last6=Schulzke|first6=J. D.|last7=Fromm|first7=M|doi=10.1242/jcs.00165}}
5. ^{{cite journal| last1 = Rosenthal | first1 = R.| last2 = Milatz | first2 = S.| last3 = Krug | first3 = S. M.| last4 = Oelrich | first4 = B.| last5 = Schulzke | first5 = J. -D.| last6 = Amasheh | first6 = S.| last7 = Gunzel | first7 = D.| last8 = Fromm | first8 = M.| doi = 10.1242/jcs.060665| title = Claudin-2, a component of the tight junction, forms a paracellular water channel| journal = Journal of Cell Science| volume = 123| issue = 11| pages = 1913–1921| year = 2010| pmid = 20460438| pmc = }}
External links Further reading {{refbegin | 2}}- {{cite journal | vauthors=Kniesel U, Wolburg H |title=Tight junctions of the blood–brain barrier |journal=Cell. Mol. Neurobiol. |volume=20 |issue= 1 |pages= 57–76 |year= 2000 |pmid= 10690502 |doi=10.1023/A:1006995910836 }}
- {{cite journal | vauthors=Heiskala M, Peterson PA, Yang Y |title=The roles of claudin superfamily proteins in paracellular transport |journal=Traffic |volume=2 |issue= 2 |pages= 93–8 |year= 2001 |pmid= 11247307 |doi=10.1034/j.1600-0854.2001.020203.x }}
- {{cite journal | vauthors=Tsukita S, Furuse M, Itoh M |title=Multifunctional strands in tight junctions |journal=Nat. Rev. Mol. Cell Biol. |volume=2 |issue= 4 |pages= 285–93 |year= 2001 |pmid= 11283726 |doi= 10.1038/35067088 }}
- {{cite journal | vauthors=Tsukita S, Furuse M |title=Claudin-based barrier in simple and stratified cellular sheets |journal=Curr. Opin. Cell Biol. |volume=14 |issue= 5 |pages= 531–6 |year= 2003 |pmid= 12231346 |doi=10.1016/S0955-0674(02)00362-9 }}
- {{cite journal | vauthors=González-Mariscal L, Betanzos A, Nava P, Jaramillo BE |title=Tight junction proteins |journal=Prog. Biophys. Mol. Biol. |volume=81 |issue= 1 |pages= 1–44 |year= 2003 |pmid= 12475568 |doi=10.1016/S0079-6107(02)00037-8 }}
- {{cite journal | vauthors=Furuse M, Fujita K, Hiiragi T |title=Claudin-1 and -2: Novel Integral Membrane Proteins Localizing at Tight Junctions with No Sequence Similarity to Occludin |journal=J. Cell Biol. |volume=141 |issue= 7 |pages= 1539–50 |year= 1998 |pmid= 9647647 |doi=10.1083/jcb.141.7.1539 | pmc=2132999 |display-authors=etal}}
- {{cite journal | vauthors=Itoh M, Furuse M, Morita K |title=Direct Binding of Three Tight Junction-Associated Maguks, Zo-1, Zo-2, and Zo-3, with the Cooh Termini of Claudins |journal=J. Cell Biol. |volume=147 |issue= 6 |pages= 1351–63 |year= 2000 |pmid= 10601346 |doi=10.1083/jcb.147.6.1351 | pmc=2168087 |display-authors=etal}}
- {{cite journal | vauthors=Sakaguchi T, Gu X, Golden HM |title=Cloning of the human claudin-2 5'-flanking region revealed a TATA-less promoter with conserved binding sites in mouse and human for caudal-related homeodomain proteins and hepatocyte nuclear factor-1alpha |journal=J. Biol. Chem. |volume=277 |issue= 24 |pages= 21361–70 |year= 2002 |pmid= 11934881 |doi= 10.1074/jbc.M110261200 |display-authors=etal}}
- {{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
- {{cite journal | vauthors=Colegio OR, Van Itallie C, Rahner C, Anderson JM |title=Claudin extracellular domains determine paracellular charge selectivity and resistance but not tight junction fibril architecture |journal=Am. J. Physiol., Cell Physiol. |volume=284 |issue= 6 |pages= C1346–54 |year= 2003 |pmid= 12700140 |doi= 10.1152/ajpcell.00547.2002 }}
- {{cite journal | vauthors=Clark HF, Gurney AL, Abaya E |title=The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003 | pmc=403697 |display-authors=etal}}
- {{cite journal | vauthors=Mankertz J, Hillenbrand B, Tavalali S |title=Functional crosstalk between Wnt signaling and Cdx-related transcriptional activation in the regulation of the claudin-2 promoter activity |journal=Biochem. Biophys. Res. Commun. |volume=314 |issue= 4 |pages= 1001–7 |year= 2004 |pmid= 14751232 |doi=10.1016/j.bbrc.2003.12.185 |display-authors=etal}}
- {{cite journal | vauthors=Yamauchi K, Rai T, Kobayashi K |title=Disease-causing mutant WNK4 increases paracellular chloride permeability and phosphorylates claudins |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 13 |pages= 4690–4 |year= 2004 |pmid= 15070779 |doi= 10.1073/pnas.0306924101 | pmc=384808 |display-authors=etal}}
- {{cite journal | vauthors=Escaffit F, Boudreau F, Beaulieu JF |title=Differential expression of claudin-2 along the human intestine: Implication of GATA-4 in the maintenance of claudin-2 in differentiating cells |journal=J. Cell. Physiol. |volume=203 |issue= 1 |pages= 15–26 |year= 2005 |pmid= 15389642 |doi= 10.1002/jcp.20189 }}
- {{cite journal | vauthors = Liu F, Koval M, Ranganathan S, Fanayan S, Hancock WS, Lundberg EK, Beavis RC, Lane L, Duek P, McQuade L, Kelleher NL, Baker MS | title = A systems proteomics view of the endogenous human claudin protein family | journal = J Proteome Res | date= 2015 | pmid = 26680015 | doi = 10.1021/acs.jproteome.5b00769 | url = https://archive-ouverte.unige.ch/unige:79118/ATTACHMENT01 }}
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