| 释义 |
- References
- External links
- Further reading
{{Infobox_gene}}C-type lectin domain family 1 member A is a protein that in humans is encoded by the CLEC1A gene.[1][2][3]This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded protein may play a role in regulating dendritic cell function. Alternative splice variants have been described but their biological nature has not been determined. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region.[4] References1. ^{{cite journal | vauthors = Colonna M, Samaridis J, Angman L | title = Molecular characterization of two novel C-type lectin-like receptors, one of which is selectively expressed in human dendritic cells | journal = Eur J Immunol | volume = 30 | issue = 2 | pages = 697–704 |date=Mar 2000 | pmid = 10671229 | pmc = | doi = 10.1002/1521-4141(200002)30:2<697::AID-IMMU697>3.0.CO;2-M }}
2. ^{{cite journal | vauthors = Sobanov Y, Bernreiter A, Derdak S, Mechtcheriakova D, Schweighofer B, Duchler M, Kalthoff F, Hofer E | title = A novel cluster of lectin-like receptor genes expressed in monocytic, dendritic and endothelial cells maps close to the NK receptor genes in the human NK gene complex | journal = Eur J Immunol | volume = 31 | issue = 12 | pages = 3493–503 |date=Dec 2001 | pmid = 11745369 | pmc = | doi =10.1002/1521-4141(200112)31:12<3493::AID-IMMU3493>3.0.CO;2-9 }}
3. ^{{cite web | title = Entrez Gene: CLEC1A C-type lectin domain family 1, member A| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51267| accessdate = }}
4. ^{{cite web | title = Entrez Gene: CLEC1A C-type lectin domain family 1, member A| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51267| accessdate = }}
External links- {{UCSC gene info|CLEC1A}}
Further reading{{refbegin | 2}}- {{cite journal | author=Drickamer K |title=C-type lectin-like domains. |journal=Curr. Opin. Struct. Biol. |volume=9 |issue= 5 |pages= 585–90 |year= 1999 |pmid= 10508765 |doi=10.1016/S0959-440X(99)00009-3 }}
- {{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
- {{cite journal | vauthors=Ebner S, Sharon N, Ben-Tal N |title=Evolutionary analysis reveals collective properties and specificity in the C-type lectin and lectin-like domain superfamily. |journal=Proteins |volume=53 |issue= 1 |pages= 44–55 |year= 2003 |pmid= 12945048 |doi= 10.1002/prot.10440 }}
- {{cite journal | vauthors=Clark HF, Gurney AL, Abaya E |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003 | pmc=403697 |display-authors=etal}}
- {{cite journal | vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal}}
- {{cite journal | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
- {{cite journal | vauthors=Otsuki T, Ota T, Nishikawa T |title=Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. |journal=DNA Res. |volume=12 |issue= 2 |pages= 117–26 |year= 2007 |pmid= 16303743 |doi= 10.1093/dnares/12.2.117 |display-authors=etal}}
{{refend}}{{gene-12-stub}} 1 : C-type lectins |