“Clentiazem”的意思、由来-开放百科全书

词条

Clentiazem

释义

References

{{chembox
| Verifiedfields = changed
| Watchedfields = changed
| verifiedrevid = 444540941
| ImageFile=Clentiazem structure.svg
| ImageSize=
| IUPACName=acetic acid [(2S,3S)-8-chloro-5-(2-dimethylaminoethyl)-2-(4-methoxyphenyl)-4-oxo-2,3-dihydro-1,5-benzothiazepin-3-yl] ester
| OtherNames=
|Section1={{Chembox Identifiers
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII = 40DK034DRC
| CASNo_Ref = {{cascite|correct|??}}
| CASNo=111659-76-8
| PubChem= 57026
| SMILES=CC(=O)OC1C(SC2=C(C=CC(=C2)Cl)N(C1=O)CCN(C)C)C3=CC=C(C=C3)OC
| ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}}
| ChemSpiderID = 51418
| InChI = 1/C22H25ClN2O4S/c1-14(26)29-20-21(15-5-8-17(28-4)9-6-15)30-19-13-16(23)7-10-18(19)25(22(20)27)12-11-24(2)3/h5-10,13,20-21H,11-12H2,1-4H3/t20-,21+/m1/s1
| InChIKey = GYKFWCDBQAFCLJ-RTWAWAEBBL
| StdInChI_Ref = {{stdinchicite|changed|chemspider}}
| StdInChI = 1S/C22H25ClN2O4S/c1-14(26)29-20-21(15-5-8-17(28-4)9-6-15)30-19-13-16(23)7-10-18(19)25(22(20)27)12-11-24(2)3/h5-10,13,20-21H,11-12H2,1-4H3/t20-,21+/m1/s1
| StdInChIKey_Ref = {{stdinchicite|changed|chemspider}}
| StdInChIKey = GYKFWCDBQAFCLJ-RTWAWAEBSA-N
|Section2={{Chembox Properties
| Formula=C₂₂H₂₅ClN₂O₄S
| MolarMass=448.9629
| Appearance=
| Density=
| MeltingPt=
| BoilingPt=
| Solubility=
|Section3={{Chembox Hazards
| MainHazards=
| FlashPt=
| AutoignitionPt =
}}Clentiazem is a calcium channel blocker.^[1]

It is a chloride derivative of diltiazem.^[2]

References

1. ^{{cite journal |vauthors=Giasson S, Garceau D, Homsy W, Dumont L |title=Pharmacodynamics and pharmacokinetics of clentiazem and diltiazem in closed-chest anesthetized dogs |journal=Cardiovasc Drugs Ther |volume=9 |issue=5 |pages=685–92 |date=October 1995 |pmid=8573551 |doi= 10.1007/BF00878551|url=}}
2. ^{{cite journal |vauthors=Dagenais F, Hollmann C, Buluran J, Cartier R |title=Clentiazem and diltiazem preserve endothelium-dependent relaxation following global rat heart ischemia |journal=Can J Cardiol |volume=11 |issue=9 |pages=816–22 |date=October 1995 |pmid=7585280 |doi= |url=}}

5 : Calcium channel blockers|Benzothiazoles|Lactams|Chloroarenes|Acetate esters

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