| 词条 | Climazolam |
| 释义 |
| IUPAC_name = 8-Chloro-6-(2-chlorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine | image = Climazolam.svg | width = 160 | tradename = Climasol | Drugs.com = {{drugs.com|international|climazolam}} | legal_CA = Schedule IV | legal_status = | bioavailability = | metabolism = | elimination_half-life = | excretion = | CAS_number = 59467-77-5 | ATCvet = yes | ATC_prefix = N05 | ATC_suffix = CD90 | PubChem = 68790 | ChemSpiderID = 62030 | ChEMBL = 2104070 | UNII_Ref = {{fdacite|correct|FDA}} | UNII = O9KZB9HG1Y | KEGG = D07714 | C=18 | H=13 | Cl=2 | N=3 | molecular_weight = 342.222 g/mol | smiles = ClC1=CC=CC=C1C2=NCC3=CN=C(C)N3C4=C2C=C(C=C4)Cl }}Climazolam[1] (Ro21-3982) was introduced under licence as a veterinary medicine by the Swiss Pharmaceutical company Gräub under the tradename Climasol.[2] Climazolam is a benzodiazepine, specifically an imidazobenzodiazepine derivative developed by Hoffman-LaRoche. It is similar in structure to midazolam and diclazepam and is used in veterinary medicine for anesthetizing animals.[3][4] References1. ^US 4280957 - Imidazodiazepines and processes therefor {{Benzodiazepines}}{{GABAAR PAMs}}{{sedative-stub}}2. ^https://www.drugs.com/international/climazolam.html 3. ^{{cite journal | vauthors = Ganter M, Kanngiesser M | title = Effect of ketamine and its combinations with xylazine and climazolam on the circulation and respiration in swine | language = German | journal = Zentralbl Veterinarmed A | date = Aug 1991| volume = 38 | issue = 7 | pages = 501–509 | pmid=1950241}} 4. ^{{cite journal | vauthors = Bettschart-Wolfensberger R, Taylor PM, Sear JW, Bloomfield MR, Rentsch K, Dawling S | title = Physiologic effects of anesthesia induced and maintained by intravenous administration of a climazolam-ketamine combination in ponies premedicated with acepromazine and xylazine | journal = American Journal of Veterinary Research | date = Oct 1996 | volume = 57 | issue = 10 | pages = 1472-1477 | pmid= 8896687}} 4 : Benzodiazepines|Chloroarenes|GABAA receptor positive allosteric modulators|Imidazobenzodiazepines |
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