| 词条 | Clocortolone pivalate |
| 释义 |
| Verifiedfields = | Watchedfields = | verifiedrevid = | IUPAC_name = [2-[(6S,8S,9R,10S,11S,13S,14S,16R,17S)-9-Chloro-6-fluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-7,8,11,12,14,15,16,17-octahydro-6H-cyclopenta[a]phenanthren-17-yl]-2-oxoethyl] 2,2-dimethylpropanoate | image = Clocortolone pivalate.svg | width = | tradename = Cilder, Cloderm, Purantix | pregnancy_AU = | pregnancy_US = | pregnancy_category = | legal_AU = | legal_CA = | legal_UK = | legal_US = | legal_status = | routes_of_administration = | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion = | CAS_number_Ref = | CAS_number = 34097-16-0 | CAS_supplemental = | class = Corticosteroid; Glucocorticoid | ATC_prefix = | ATC_suffix = | ATC_supplemental = | PubChem = 5282493 | IUPHAR_ligand = | DrugBank_Ref = | DrugBank = | ChemSpiderID_Ref = | ChemSpiderID = 4445634 | UNII = QBL8IZH14X | KEGG = D02287 | ChEBI = 59583 | ChEMBL = 1200975 | C=27 | H=36 | Cl=1 | F=1 | O=5 | SMILES = C[C@@H]1C[C@H]2[C@@H]3C[C@@H](C4=CC(=O)C=C[C@@]4([C@]3([C@H](C[C@@]2([C@H]1C(=O)COC(=O)C(C)(C)C)C)O)Cl)C)F | StdInChI_Ref = | StdInChI = 1S/C27H36ClFO5/c1-14-9-16-17-11-19(29)18-10-15(30)7-8-26(18,6)27(17,28)21(32)12-25(16,5)22(14)20(31)13-34-23(33)24(2,3)4/h7-8,10,14,16-17,19,21-22,32H,9,11-13H2,1-6H3/t14-,16+,17+,19+,21+,22-,25+,26+,27+/m1/s1 | StdInChIKey_Ref = | StdInChIKey = SXYZQZLHAIHKKY-GSTUPEFVSA-N | synonyms = Clocortolone trimethylacetate; CL-68; SH-863; 9α-Chloro-6α-fluoro-11β,21-dihydroxy-16α-methylpregna-1,4-diene-3,20-dione 21-pivalate }}Clocortolone pivalate (brand names Cilder, Cloderm, Purantix), also known as clocortolone trimethylacetate, is a synthetic glucocorticoid corticosteroid and corticosteroid ester which is marketed in the United States and Austria.[1][2][3] It is the C21 pivalate (trimethylacetate) ester of clocortolone,[1][2] and acts as a prodrug of clocortolone in the body.[4][5] References1. ^1 {{cite book|author=J. Elks|title=The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies|url=https://books.google.com/books?id=0vXTBwAAQBAJ&pg=PA293|date=14 November 2014|publisher=Springer|isbn=978-1-4757-2085-3|pages=293–}} {{Glucocorticoids and antiglucocorticoids}}{{Glucocorticoid receptor modulators}}{{steroid-stub}}2. ^1 {{cite book|title=Index Nominum 2000: International Drug Directory|url=https://books.google.com/books?id=5GpcTQD_L2oC&pg=PA253|year=2000|publisher=Taylor & Francis|isbn=978-3-88763-075-1|pages=253–}} 3. ^{{cite book|author1=I.K. Morton|author2=Judith M. Hall|title=Concise Dictionary of Pharmacological Agents: Properties and Synonyms|url=https://books.google.com/books?id=tsjrCAAAQBAJ&pg=PA79|date=6 December 2012|publisher=Springer Science & Business Media|isbn=978-94-011-4439-1|pages=79–}} 4. ^https://www.google.com/patents/US5073641 5. ^{{cite book|author1=Valentino Stella|author2=Ronald Borchardt|author3=Michael Hageman|author4=Reza Oliyai, Hans Maag, Jefferson Tilley|title=Prodrugs: Challenges and Rewards|url=https://books.google.com/books?id=qkjHxX5TgHEC&pg=PA220|date=12 March 2007|publisher=Springer Science & Business Media|isbn=978-0-387-49782-2|pages=220–}} 8 : Alcohols|Chloroarenes|Corticosteroid esters|Fluoroarenes|Glucocorticoids|Pivalates|Pregnanes|Prodrugs |
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