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词条 CLSPN
释义

  1. Function

  2. Interactions

  3. References

  4. External links

  5. Further reading

{{Infobox_gene}}Claspin is a protein that in humans is encoded by the CLSPN gene.[1][2][3]

Function

Xenopus claspin is an essential upstream regulator of checkpoint kinase 1 and triggers a checkpoint arrest of the cell cycle in the presence of DNA templates in Xenopus egg extracts. The human gene appears to be the homolog Xenopus claspin and its function has not been determined.[3]

Interactions

CLSPN has been shown to interact with:

{{div col|colwidth=20em}}
  • BRCA1,[4]
  • CDC45,[5]
  • CHEK1,[2]
  • POLE,[5]
  • RAD17,[5] and
  • USP7.[6]
{{Div col end}}

References

1. ^{{cite journal | vauthors = Kumagai A, Dunphy WG | title = Claspin, a novel protein required for the activation of Chk1 during a DNA replication checkpoint response in Xenopus egg extracts | journal = Mol Cell | volume = 6 | issue = 4 | pages = 839–49 |date=Nov 2000 | pmid = 11090622 | pmc = | doi =10.1016/S1097-2765(05)00092-4 }}
2. ^1 {{cite journal | vauthors = Chini CC, Chen J | title = Human claspin is required for replication checkpoint control | journal = J Biol Chem | volume = 278 | issue = 32 | pages = 30057–62 |date=Aug 2003 | pmid = 12766152 | pmc = | doi = 10.1074/jbc.M301136200 }}
3. ^1 {{cite web | title = Entrez Gene: CLSPN claspin homolog (Xenopus laevis)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=63967| accessdate = }}
4. ^{{cite journal | vauthors = Lin SY, Li K, Stewart GS, Elledge SJ | title = Human Claspin works with BRCA1 to both positively and negatively regulate cell proliferation | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 101 | issue = 17 | pages = 6484–9 | year = 2004 | pmid = 15096610 | pmc = 404071 | doi = 10.1073/pnas.0401847101 }}
5. ^1 2 {{cite journal | vauthors = Serçin O, Kemp MG | title = Characterization of functional domains in human Claspin | journal = Cell Cycle | volume = 10 | issue = 10 | pages = 1599–606 |date=May 2011 | pmid = 21478680 | pmc = 3127160 | doi = 10.4161/cc.10.10.15562}}
6. ^{{cite journal | vauthors = Faustrup H, Bekker-Jensen S, Bartek J, Lukas J, Mailand N | title = USP7 counteracts SCFbetaTrCP- but not APCCdh1-mediated proteolysis of Claspin | journal = J. Cell Biol. | volume = 184 | issue = 1 | pages = 13–9 | year = 2009 | pmid = 19124652 | pmc = 2615094 | doi = 10.1083/jcb.200807137 }}

External links

  • {{UCSC gene info|CLSPN}}

Further reading

{{refbegin | 2}}
  • {{cite journal | vauthors=Chini CC, Chen J |title=Claspin, a regulator of Chk1 in DNA replication stress pathway. |journal=DNA Repair (Amst.) |volume=3 |issue= 8-9 |pages= 1033–7 |year= 2005 |pmid= 15279790 |doi= 10.1016/j.dnarep.2004.03.001 }}
  • {{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
  • {{cite journal | vauthors=Lin SY, Li K, Stewart GS, Elledge SJ |title=Human Claspin works with BRCA1 to both positively and negatively regulate cell proliferation. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 17 |pages= 6484–9 |year= 2004 |pmid= 15096610 |doi= 10.1073/pnas.0401847101 | pmc=404071 }}
  • {{cite journal | vauthors=Sørensen CS, Syljuåsen RG, Lukas J, Bartek J |title=ATR, Claspin and the Rad9-Rad1-Hus1 complex regulate Chk1 and Cdc25A in the absence of DNA damage. |journal=Cell Cycle |volume=3 |issue= 7 |pages= 941–5 |year= 2006 |pmid= 15190204 |doi= 10.4161/cc.3.7.972}}
  • {{cite journal | vauthors=Sar F, Lindsey-Boltz LA, Subramanian D |title=Human claspin is a ring-shaped DNA-binding protein with high affinity to branched DNA structures. |journal=J. Biol. Chem. |volume=279 |issue= 38 |pages= 39289–95 |year= 2004 |pmid= 15226314 |doi= 10.1074/jbc.M405793200 |display-authors=etal}}
  • {{cite journal | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
  • {{cite journal | vauthors=Clarke CA, Clarke PR |title=DNA-dependent phosphorylation of Chk1 and Claspin in a human cell-free system. |journal=Biochem. J. |volume=388 |issue= Pt 2 |pages= 705–12 |year= 2005 |pmid= 15707391 |doi= 10.1042/BJ20041966 | pmc=1138979 }}
  • {{cite journal | vauthors=Clarke CA, Bennett LN, Clarke PR |title=Cleavage of claspin by caspase-7 during apoptosis inhibits the Chk1 pathway. |journal=J. Biol. Chem. |volume=280 |issue= 42 |pages= 35337–45 |year= 2005 |pmid= 16123041 |doi= 10.1074/jbc.M506460200 }}
  • {{cite journal | vauthors=Chini CC, Wood J, Chen J |title=Chk1 is required to maintain claspin stability. |journal=Oncogene |volume=25 |issue= 30 |pages= 4165–71 |year= 2006 |pmid= 16501606 |doi= 10.1038/sj.onc.1209447 }}
  • {{cite journal | vauthors=Gregory SG, Barlow KF, McLay KE |title=The DNA sequence and biological annotation of human chromosome 1. |journal=Nature |volume=441 |issue= 7091 |pages= 315–21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727 |display-authors=etal}}
  • {{cite journal | vauthors=Bennett LN, Clarke PR |title=Regulation of Claspin degradation by the ubiquitin-proteosome pathway during the cell cycle and in response to ATR-dependent checkpoint activation. |journal=FEBS Lett. |volume=580 |issue= 17 |pages= 4176–81 |year= 2006 |pmid= 16828751 |doi= 10.1016/j.febslet.2006.06.071 }}
  • {{cite journal | vauthors=Liu S, Bekker-Jensen S, Mailand N |title=Claspin operates downstream of TopBP1 to direct ATR signaling towards Chk1 activation. |journal=Mol. Cell. Biol. |volume=26 |issue= 16 |pages= 6056–64 |year= 2006 |pmid= 16880517 |doi= 10.1128/MCB.00492-06 | pmc=1592810 |display-authors=etal}}
  • {{cite journal | vauthors=Mailand N, Bekker-Jensen S, Bartek J, Lukas J |title=Destruction of Claspin by SCFbetaTrCP restrains Chk1 activation and facilitates recovery from genotoxic stress. |journal=Mol. Cell |volume=23 |issue= 3 |pages= 307–18 |year= 2006 |pmid= 16885021 |doi= 10.1016/j.molcel.2006.06.016 }}
  • {{cite journal | vauthors=Peschiaroli A, Dorrello NV, Guardavaccaro D |title=SCFbetaTrCP-mediated degradation of Claspin regulates recovery from the DNA replication checkpoint response. |journal=Mol. Cell |volume=23 |issue= 3 |pages= 319–29 |year= 2006 |pmid= 16885022 |doi= 10.1016/j.molcel.2006.06.013 |display-authors=etal}}
  • {{cite journal | vauthors=Mamely I, van Vugt MA, Smits VA |title=Polo-like kinase-1 controls proteasome-dependent degradation of Claspin during checkpoint recovery. |journal=Curr. Biol. |volume=16 |issue= 19 |pages= 1950–5 |year= 2006 |pmid= 16934469 |doi= 10.1016/j.cub.2006.08.026 |display-authors=etal}}
  • {{cite journal | vauthors=Rodríguez-Bravo V, Guaita-Esteruelas S, Florensa R |title=Chk1- and claspin-dependent but ATR/ATM- and Rad17-independent DNA replication checkpoint response in HeLa cells. |journal=Cancer Res. |volume=66 |issue= 17 |pages= 8672–9 |year= 2007 |pmid= 16951182 |doi= 10.1158/0008-5472.CAN-05-4443 |display-authors=etal}}
  • {{cite journal | vauthors=Chini CC, Chen J |title=Repeated phosphopeptide motifs in human Claspin are phosphorylated by Chk1 and mediate Claspin function. |journal=J. Biol. Chem. |volume=281 |issue= 44 |pages= 33276–82 |year= 2006 |pmid= 16963448 |doi= 10.1074/jbc.M604373200 }}
  • {{cite journal | vauthors=Sercin O, Kemp MG | title=Characterization of functional domains in human Claspin.

|journal=Cell Cycle |volume=10 |issue= 10 |pages= 1599–606 |year= 2011|pmid= 21478680 |doi= 10.4161/cc.10.10.15562 |pmc=3127160}}{{refend}}{{gene-1-stub}}
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