| 词条 | Codeine methylbromide |
| 释义 |
| Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 428852152 | IUPAC_name = 7,8-Didehydro-17,17-dimethyl-4,5-α-epoxy-6α-hydroxy-3-methoxymorphinanium bromide | image = Codeine methylbromide.png | width = 180 | tradename = | Drugs.com = {{drugs.com|monograph|codeine}} | pregnancy_AU = | pregnancy_US = | pregnancy_category = | legal_AU = | legal_CA = | legal_UK = | legal_US = Schedule I | legal_status = | routes_of_administration = | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion = | CAS_number_Ref = {{cascite|correct|??}} | CAS_number = 125-27-9 | ATC_prefix = | ATC_suffix = | PubChem = 5362447 | DrugBank_Ref = {{drugbankcite|correct|drugbank}} | DrugBank = | ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}} | ChemSpiderID = 4515039 | StdInChI_Ref = {{stdinchicite|changed|chemspider}} | StdInChI = 1S/C19H24NO3.BrH/c1-20(2)9-8-19-12-5-6-14(21)18(19)23-17-15(22-3)7-4-11(16(17)19)10-13(12)20;/h4-7,12-14,18,21H,8-10H2,1-3H3;1H/q+1;/p-1/t12-,13+,14-,18-,19-;/m0./s1 | StdInChIKey_Ref = {{stdinchicite|changed|chemspider}} | StdInChIKey = KIKLDWULAZATJG-YZZSNFJZSA-M | C=19 | H=24 | Br=1 | N=1 | O=3 | molecular_weight = 394.30 g/mol | smiles = C[N+]1(CC[C@]23[C@@H]4[C@H]1CC5=C2C(=C(C=C5)OC)O[C@H]3[C@H](C=C4)O)C.[Br-] | synonyms = Codeine bromomethylate, 125-27-9, DEA No. 9070 }}Codeine methylbromide (Eucodin) is the bromomethane (methylbromide) salt of codeine. Its possession is prohibited in many jurisdictions. It is considered a Schedule I controlled substance in the United States, with a DEA ACSCN of 9070 and nil annual aggregate manufacturing quota.[1] as of 2014. As it is used in a different way than basic salts of codeine like the phosphate or hydrochloride owing to its below-mentioned dual action, it is considered to be a different drug related to codeine rather than merely a salt of it in many contexts.[2] Also known by the genericised trade name eucodeine, and the salt name also sometimes given as methobromide, this drug was first synthesised in Austria-Hungary in 1903. As it is a bromide in addition to a codeine salt, it has a dual mechanism of action and is indicated for pain with insomnia or nervousness and violent coughing.[3] This codeine-based bromide also has morphine, dihydrocodeine, dihydromorphine, hydromorphone, isocodeine, hydrocodone, and other such analogues; also, there are codeine-based barbiturates and salicylates.[4] References{{Refimprove|date=March 2017}}1. ^http://deadiversion.usdoj.gov/quotas/conv_factor/index.html {{Opioidergics}}{{analgesic-stub}}2. ^ 4 : Morphinans|Alcohols|Opioids|Phenol ethers |
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