| 词条 | Codoxime |
| 释义 |
| IUPAC_name = (((4,5α-Epoxy-3-methoxy-17-methylmorphinan-6-ylidene)amino)oxy)acetic acid | image = Codoxime.svg | width = 220 | tradename = | pregnancy_AU = | pregnancy_US = | pregnancy_category = | legal_AU = | legal_CA = Schedule I | legal_UK = | legal_US = | legal_UN = N I | legal_DE = Anlage I | routes_of_administration = | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion = | CAS_number = 7125-76-0 | ATC_prefix = none | ATC_suffix = | PubChem = 9570253 | DrugBank = | ChEMBL = 2107300 | ChemSpiderID = 7844721 | UNII_Ref = {{fdacite|correct|FDA}} | UNII = JT5I2F57F7 | KEGG = D03581 | C=20 | H=24 | N=2 | O=5 | molecular_weight = 372.415 g/mol | smiles = O=C(O)CO\=C4\\[C@@H]5Oc1c2c(ccc1OC)C[C@H]3N(CC[C@]25[C@H]3CC4)C | synonyms = Codoxime }}Codoxime (Codossima) is an opiate analogue that is a derivative of hydrocodone, where the 6-ketone group has been replaced by carboxymethyloxime. It has primarily antitussive effects[1] and was found to have moderate potential to cause dependence in animal studies.[2] References1. ^Jack Fishman. Morphinone and Codeinone Derivatives. US Patent 3153042 {{Opioidergics}}{{analgesic-stub}}2. ^Jasinski DR, Martin WR. Assessment of the dependence-producing properties of dihydrocodeinone and codoxime. Clinical Pharmacology and Therapeutics. 1967 Mar-Apr;8(2):266-70. {{PMID|6021586}} 5 : Antitussives|Morphinans|Phenol ethers|Mu-opioid agonists|Semisynthetic opioids |
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