| 词条 | Collybistin |
| 释义 |
Collybistin is a protein identified as a regulator of the localization of gephyrin, inducing the formation of submembrane gephyrin aggregates that accumulate glycine and GABA receptors. In 2000 it was identified as a gephyrin binding partner, and an important determinant of inhibitory postsynaptic membrane formation and plasticity.[1] Gephyrin and collybistin are recruited to developing postsynaptic membranes of inhibitory synapses by the trans-synaptic adhesion molecule neuroligin-2,[2] where they provide the scaffold for the clustering of inhibitory postsynaptic receptors to form a functioning inhibitory synapse. References1. ^{{cite journal | doi = 10.1038/71096 | last1 = Betz | pmid = 10607391 | year = 2000 | first1 = Heinrich | pages = 22–9 | issue = 1 | volume = 3 | journal = Nature Neuroscience | last2 = Kins | first2 = Stefan | last3 = Kirsch | first3 = Joachim | title = Collybistin, a newly identified brain-specific GEF, induces submembrane clustering of gephyrin.| url = http://www.nature.com/neuro/journal/v3/n1/full/nn0100_22.html}} {{protein-stub}}2. ^{{cite journal |last1=Poulopoulos |first1=Alexandros |last2=Aramuni |first2=Gayane |last3=Meyer |first3=Guido |last4=Soykan |first4=Tolga |last5=Hoon |first5=Mrinalini |last6=Papadopoulos |first6=Theofilos |last7=Zhang |first7=Mingyue |last8=Paarmann |first8=Ingo |last9=Fuchs |first9=CéLine |last10=Harvey |first10=Kirsten |last11=Jedlicka |first11=Peter |last12=Schwarzacher |first12=Stephan W. |last13=Betz |first13=Heinrich |last14=Harvey |first14=Robert J. |last15=Brose |first15=Nils |last16=Zhang |first16=Weiqi |last17=Varoqueaux |first17=Frédérique |title=Neuroligin 2 Drives Postsynaptic Assembly at Perisomatic Inhibitory Synapses through Gephyrin and Collybistin |journal=Neuron |volume=63 |issue=5 |pages=628–42 |year=2009 |pmid=19755106 |doi=10.1016/j.neuron.2009.08.023|display-authors=8 }} 1 : GTP-binding protein regulators |
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