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词条 Homoserine
释义

  1. References

{{chembox
| Verifiedimages = changed
| Verifiedfields = changed
| Watchedfields = changed
| verifiedrevid = 461770636
| Name = L-Homoserine
| ImageFile_Ref = {{chemboximage|correct|??}}
| ImageFile = L-Homoserin.svg
| ImageSize = 180px
| ImageName = Skeletal formula
| ImageFile1 = L-Homoserine-zwitterion-3D-balls.png
| ImageSize1 = 120px
| ImageName1 = Ball-and-stick model of the zwitterion
| IUPACName = (S)-2-Amino-4-hydroxybutanoic acid
|Section1={{Chembox Identifiers
| InChI = 1/C4H9NO3/c5-3(1-2-6)4(7)8/h3,6H,1-2,5H2,(H,7,8)
| ChEBI_Ref = {{ebicite|correct|EBI}}
| ChEBI = 30653
| SMILES = O=C(O)C(N)CCO
| InChIKey = UKAUYVFTDYCKQA-UHFFFAOYAZ
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| StdInChI = 1S/C4H9NO3/c5-3(1-2-6)4(7)8/h3,6H,1-2,5H2,(H,7,8)
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
| StdInChIKey = UKAUYVFTDYCKQA-UHFFFAOYSA-N
| CASNo = 672-15-1
| CASNo_Ref = {{cascite|correct|CAS}}
| EC_number = 211-590-6
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID = 758
| PubChem = 779
| ChEMBL_Ref = {{ebicite|changed|EBI}}
| ChEMBL = 11722
}}
|Section2={{Chembox Properties
| Formula = C4H9NO3
| MolarMass = 119.12 g/mol
| MeltingPt = 203 °C (decomposes)
}}

Homoserine (also called isothreonine) is an α-amino acid with the chemical formula HO2CCH(NH2)CH2CH2OH. L-Homoserine is not one of the common amino acids encoded by DNA. It differs from the proteinogenic amino acid serine by insertion of an additional -CH2- unit into the backbone. Homoserine, or its lactone form, is the product of a cyanogen bromide cleavage of a peptide by degradation of methionine.

Homoserine is an intermediate in the biosynthesis of three essential amino acids: methionine, threonine (an isomer of homoserine), and isoleucine. It forms by two reductions of aspartic acid via the intermediacy of aspartate semialdehyde.[1]

References

1. ^Berg, J. M.; Stryer, L. et al. (2002), Biochemistry. W.H. Freeman. {{ISBN|0-7167-4684-0}}
{{biochem-stub}}

2 : Amino acids|Non-proteinogenic amino acids

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