请输入您要查询的百科知识：

　

词条 COP9 constitutive photomorphogenic homolog subunit 5
释义

  1. Function

  2. Interactions

  3. See also

  4. References

  5. External links

  6. Further reading

{{Infobox_gene}}COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis), also known as COPS5 or Csn5, is a gene conserved from humans to Saccharomyces cerevisiae.[1]

Function

The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein is reported to be involved in the degradation of cyclin-dependent kinase inhibitor CDKN1B/p27Kip1. It is also known to be a coactivator that increases the specificity of JUN/AP1 transcription factors.[1]

Interactions

COP9 constitutive photomorphogenic homolog subunit 5 has been shown to interact with Macrophage migration inhibitory factor,[2][3] GFER,[4] BCL3,[5] Ubiquitin carboxy-terminal hydrolase L1,[6] S100A7[7] and C-jun.[8]

See also

  • COPS1
  • COPS2
  • COPS3
  • COPS4
  • COPS6
  • COPS7A
  • COPS7B
  • COPS8

References

1. ^1 {{cite web | title = Entrez Gene: COPS5 COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10987| accessdate = }}
2. ^{{cite journal |last1=Ghosh |first1=S |last2=Leaton |first2=LA |last3=Farr |first3=L |last4=Barfield |first4=A |last5=Moonah |first5=S |title=Interaction between parasite-encoded JAB1/CSN5 and macrophage migration inhibitory factor proteins attenuates its proinflammatory function |journal=Scientific Reports |date=6 July 2018 |volume=8 |issue=1 |pages=10241 |doi=10.1038/s41598-018-28625-1 |pmid=29980718|pmc=6035221 }}
3. ^{{cite journal | vauthors = Kleemann R, Hausser A, Geiger G, Mischke R, Burger-Kentischer A, Flieger O, Johannes FJ, Roger T, Calandra T, Kapurniotu A, Grell M, Finkelmeier D, Brunner H, Bernhagen J | title = Intracellular action of the cytokine MIF to modulate AP-1 activity and the cell cycle through Jab1 | journal = Nature | volume = 408 | issue = 6809 | pages = 211–6 | date = November 2000 | pmid = 11089976 | doi = 10.1038/35041591 }}
4. ^{{cite journal | vauthors = Lu C, Li Y, Zhao Y, Xing G, Tang F, Wang Q, Sun Y, Wei H, Yang X, Wu C, Chen J, Guan KL, Zhang C, Chen H, He F | title = Intracrine hepatopoietin potentiates AP-1 activity through JAB1 independent of MAPK pathway | journal = FASEB J. | volume = 16 | issue = 1 | pages = 90–2 | date = January 2002 | pmid = 11709497 | doi = 10.1096/fj.01-0506fje }}
5. ^{{cite journal | vauthors = Dechend R, Hirano F, Lehmann K, Heissmeyer V, Ansieau S, Wulczyn FG, Scheidereit C, Leutz A | title = The Bcl-3 oncoprotein acts as a bridging factor between NF-kappaB/Rel and nuclear co-regulators | journal = Oncogene | volume = 18 | issue = 22 | pages = 3316–23 | date = June 1999 | pmid = 10362352 | doi = 10.1038/sj.onc.1202717 }}
6. ^{{cite journal | vauthors = Caballero OL, Resto V, Patturajan M, Meerzaman D, Guo MZ, Engles J, Yochem R, Ratovitski E, Sidransky D, Jen J | title = Interaction and colocalization of PGP9.5 with JAB1 and p27(Kip1) | journal = Oncogene | volume = 21 | issue = 19 | pages = 3003–10 | date = May 2002 | pmid = 12082530 | doi = 10.1038/sj.onc.1205390 }}
7. ^{{cite journal | vauthors = Emberley ED, Niu Y, Leygue E, Tomes L, Gietz RD, Murphy LC, Watson PH | title = Psoriasin interacts with Jab1 and influences breast cancer progression | journal = Cancer Res. | volume = 63 | issue = 8 | pages = 1954–61 | date = April 2003 | pmid = 12702588 }}
8. ^{{cite journal | vauthors = Claret FX, Hibi M, Dhut S, Toda T, Karin M | title = A new group of conserved coactivators that increase the specificity of AP-1 transcription factors | journal = Nature | volume = 383 | issue = 6599 | pages = 453–7 | date = October 1996 | pmid = 8837781 | doi = 10.1038/383453a0 }}

External links

  • {{UCSC gene info|COPS5}}

Further reading

{{refbegin | 2}}
  • {{cite journal | vauthors = Wolf DA, Zhou C, Wee S | title = The COP9 signalosome: an assembly and maintenance platform for cullin ubiquitin ligases? | journal = Nat. Cell Biol. | volume = 5 | issue = 12 | pages = 1029–33 | year = 2003 | pmid = 14647295 | doi = 10.1038/ncb1203-1029 }}
  • {{cite journal | vauthors = Claret FX, Hibi M, Dhut S, Toda T, Karin M | title = A new group of conserved coactivators that increase the specificity of AP-1 transcription factors | journal = Nature | volume = 383 | issue = 6599 | pages = 453–7 | year = 1996 | pmid = 8837781 | doi = 10.1038/383453a0 }}
  • {{cite journal | vauthors = Asano K, Vornlocher HP, Richter-Cook NJ, Merrick WC, Hinnebusch AG, Hershey JW | title = Structure of cDNAs encoding human eukaryotic initiation factor 3 subunits. Possible roles in RNA binding and macromolecular assembly | journal = J. Biol. Chem. | volume = 272 | issue = 43 | pages = 27042–52 | year = 1997 | pmid = 9341143 | doi = 10.1074/jbc.272.43.27042 }}
  • {{cite journal | vauthors = Seeger M, Kraft R, Ferrell K, Bech-Otschir D, Dumdey R, Schade R, Gordon C, Naumann M, Dubiel W | title = A novel protein complex involved in signal transduction possessing similarities to 26S proteasome subunits | journal = FASEB J. | volume = 12 | issue = 6 | pages = 469–78 | year = 1998 | pmid = 9535219 | doi = 10.1096/fasebj.12.6.469}}
  • {{cite journal | vauthors = Wei N, Tsuge T, Serino G, Dohmae N, Takio K, Matsui M, Deng XW | title = The COP9 complex is conserved between plants and mammals and is related to the 26S proteasome regulatory complex | journal = Curr. Biol. | volume = 8 | issue = 16 | pages = 919–22 | year = 1998 | pmid = 9707402 | doi = 10.1016/S0960-9822(07)00372-7 }}
  • {{cite journal | vauthors = Tomoda K, Kubota Y, Kato J | title = Degradation of the cyclin-dependent-kinase inhibitor p27Kip1 is instigated by Jab1 | journal = Nature | volume = 398 | issue = 6723 | pages = 160–5 | year = 1999 | pmid = 10086358 | doi = 10.1038/18230 }}
  • {{cite journal | vauthors = Dechend R, Hirano F, Lehmann K, Heissmeyer V, Ansieau S, Wulczyn FG, Scheidereit C, Leutz A | title = The Bcl-3 oncoprotein acts as a bridging factor between NF-kappaB/Rel and nuclear co-regulators | journal = Oncogene | volume = 18 | issue = 22 | pages = 3316–23 | year = 1999 | pmid = 10362352 | doi = 10.1038/sj.onc.1202717 }}
  • {{cite journal | vauthors = Chauchereau A, Georgiakaki M, Perrin-Wolff M, Milgrom E, Loosfelt H | title = JAB1 interacts with both the progesterone receptor and SRC-1 | journal = J. Biol. Chem. | volume = 275 | issue = 12 | pages = 8540–8 | year = 2000 | pmid = 10722692 | doi = 10.1074/jbc.275.12.8540 }}
  • {{cite journal | vauthors = Bianchi E, Denti S, Granata A, Bossi G, Geginat J, Villa A, Rogge L, Pardi R | title = Integrin LFA-1 interacts with the transcriptional co-activator JAB1 to modulate AP-1 activity | journal = Nature | volume = 404 | issue = 6778 | pages = 617–21 | year = 2000 | pmid = 10766246 | doi = 10.1038/35007098 }}
  • {{cite journal | vauthors = Kleemann R, Hausser A, Geiger G, Mischke R, Burger-Kentischer A, Flieger O, Johannes FJ, Roger T, Calandra T, Kapurniotu A, Grell M, Finkelmeier D, Brunner H, Bernhagen J | title = Intracellular action of the cytokine MIF to modulate AP-1 activity and the cell cycle through Jab1 | journal = Nature | volume = 408 | issue = 6809 | pages = 211–6 | year = 2000 | pmid = 11089976 | doi = 10.1038/35041591 }}
  • {{cite journal | vauthors = Bech-Otschir D, Kraft R, Huang X, Henklein P, Kapelari B, Pollmann C, Dubiel W | title = COP9 signalosome-specific phosphorylation targets p53 to degradation by the ubiquitin system | journal = EMBO J. | volume = 20 | issue = 7 | pages = 1630–9 | year = 2001 | pmid = 11285227 | pmc = 145508 | doi = 10.1093/emboj/20.7.1630 }}
  • {{cite journal | vauthors = Lyapina S, Cope G, Shevchenko A, Serino G, Tsuge T, Zhou C, Wolf DA, Wei N, Shevchenko A, Deshaies RJ | title = Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome | journal = Science | volume = 292 | issue = 5520 | pages = 1382–5 | year = 2001 | pmid = 11337588 | doi = 10.1126/science.1059780 }}
  • {{cite journal | vauthors = Tomoda K, Kubota Y, Arata Y, Mori S, Maeda M, Tanaka T, Yoshida M, Yoneda-Kato N, Kato JY | title = The cytoplasmic shuttling and subsequent degradation of p27Kip1 mediated by Jab1/CSN5 and the COP9 signalosome complex | journal = J. Biol. Chem. | volume = 277 | issue = 3 | pages = 2302–10 | year = 2002 | pmid = 11704659 | doi = 10.1074/jbc.M104431200 }}
  • {{cite journal | vauthors = Bae MK, Ahn MY, Jeong JW, Bae MH, Lee YM, Bae SK, Park JW, Kim KR, Kim KW | title = Jab1 interacts directly with HIF-1alpha and regulates its stability | journal = J. Biol. Chem. | volume = 277 | issue = 1 | pages = 9–12 | year = 2002 | pmid = 11707426 | doi = 10.1074/jbc.C100442200 }}
  • {{cite journal | vauthors = Lu C, Li Y, Zhao Y, Xing G, Tang F, Wang Q, Sun Y, Wei H, Yang X, Wu C, Chen J, Guan KL, Zhang C, Chen H, He F | title = Intracrine hepatopoietin potentiates AP-1 activity through JAB1 independent of MAPK pathway | journal = FASEB J. | volume = 16 | issue = 1 | pages = 90–2 | year = 2002 | pmid = 11709497 | doi = 10.1096/fj.01-0506fje }}
  • {{cite journal | vauthors = Dai YS, Cserjesi P | title = The basic helix-loop-helix factor, HAND2, functions as a transcriptional activator by binding to E-boxes as a heterodimer | journal = J. Biol. Chem. | volume = 277 | issue = 15 | pages = 12604–12 | year = 2002 | pmid = 11812799 | doi = 10.1074/jbc.M200283200 }}
  • {{cite journal | vauthors = Wan M, Cao X, Wu Y, Bai S, Wu L, Shi X, Wang N, Cao X | title = Jab1 antagonizes TGF-beta signaling by inducing Smad4 degradation | journal = EMBO Rep. | volume = 3 | issue = 2 | pages = 171–6 | year = 2002 | pmid = 11818334 | pmc = 1083965 | doi = 10.1093/embo-reports/kvf024 }}
  • {{cite journal | vauthors = Gemmill RM, Bemis LT, Lee JP, Sozen MA, Baron A, Zeng C, Erickson PF, Hooper JE, Drabkin HA | title = The TRC8 hereditary kidney cancer gene suppresses growth and functions with VHL in a common pathway | journal = Oncogene | volume = 21 | issue = 22 | pages = 3507–16 | year = 2002 | pmid = 12032852 | doi = 10.1038/sj.onc.1205437 }}
  • {{cite journal | vauthors = Caballero OL, Resto V, Patturajan M, Meerzaman D, Guo MZ, Engles J, Yochem R, Ratovitski E, Sidransky D, Jen J | title = Interaction and colocalization of PGP9.5 with JAB1 and p27(Kip1) | journal = Oncogene | volume = 21 | issue = 19 | pages = 3003–10 | year = 2002 | pmid = 12082530 | doi = 10.1038/sj.onc.1205390 }}
  • {{cite journal | vauthors = Chopra S, Fernandez De Mattos S, Lam EW, Mann DJ | title = Jab1 co-activation of c-Jun is abrogated by the serine 10-phosphorylated form of p27Kip1 | journal = J. Biol. Chem. | volume = 277 | issue = 36 | pages = 32413–6 | year = 2002 | pmid = 12119282 | doi = 10.1074/jbc.C200311200 }}
{{refend}}
随便看

　

开放百科全书收录14589846条英语、德语、日语等多语种百科知识，基本涵盖了大多数领域的百科知识，是一部内容自由、开放的电子版国际百科全书。

　

Copyright © 2023 OENC.NET All Rights Reserved
京ICP备2021023879号 更新时间：2024/11/16 1:01:04