“Coronary reflex”的意思、由来-开放百科全书

词条

Coronary reflex

释义

Causes of coronary constriction
Chemical Other
Causes of coronary dilation
Chemical
References

Coronary reflex is the change of coronary diameter in response to chemical, neurological or mechanical stimulation of the coronary arteries.

The coronary reflexes are stimulated differently from the rest of the vascular system.

Causes of coronary constriction

Chemical

N-nitro L-arginine
indomethacin
glibenclamide
tetraethylammonium chloride
caffeine

Other

Cold

Causes of coronary dilation

Cocaine abuse frequently can cause a coronary spasm, resulting in a spontaneous myocardial infarction.

Chemical

Versed (Midazolam): a coronary dilator. In midazolam's presence, dilation was unaffected by N-nitro L-arginine, indomethacin and glibenclamide.
Tetraethylammonium chloride, an inhibitor of the BKCa K+ channel (a high conductance Ca2+-sensitive K+ channel), dose dependently attenuated the vasodilating effect of midazolam ^[1]
Estrogen has been shown to abolish abnormal cold-induced coronary constriction.^[2]

References

1. ^{{cite journal | title = N-nitro L-arginine causes coronary vasoconstriction and inhibits endothelium-dependent vasodilatation in anaesthetized greyhounds|author1=O.L. Woodman |author2=G.J. Dusting | journal = Br. J. Pharmacol. | year = 1991 | volume = 103 | pages = 1407–1410 | pmid = 1909199 | issue = 2 | pmc = 1908370 | doi=10.1111/j.1476-5381.1991.tb09802.x}}
2. ^{{cite journal | doi = 10.1378/chest.114.6.1556 | title = Estrogen Acutely Abolishes Abnormal Cold-Induced Coronary Constriction in Men* |author1=Steven E. Reis, MD |author2=Richard Holubkov |author3=Kathleen A. Zell, BSN |author4=AJ. Conrad Smith, MD |author5=Howard A. Cohen, MD |author6=Marc D. Feldman, MD |author7=Roger S. Blumenthal, MD | journal = Chest | year = 1998 | volume = 114 | pages = 1556–1561 | pmid = 9872188 | issue = 6}}

1 : Cardiology

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