| 词条 | Corticotropin-releasing hormone binding protein family |
| 释义 |
| Symbol = CRF-BP | Name = Corticotropin-releasing factor binding protein (CRF-BP) | image = | width = | caption = | Pfam= PF05428 | InterPro= IPR008435 | SMART= | Prosite = | SCOP = | TCDB = | OPM family= | OPM protein= | PDB= }} Corticotropin-releasing factor binding protein family consists of several eukaryotic corticotropin-releasing factor binding proteins (CRF-BP or CRH-BP). Corticotropin-releasing hormone (CRH) plays multiple roles in vertebrate species. In mammals, it is the major hypothalamic releasing factor for pituitary adrenocorticotropin secretion, and is a neurotransmitter or neuromodulator at other sites in the central nervous system. In non-mammalian vertebrates, CRH not only acts as a neurotransmitter and hypophysiotropin, it also acts as a potent thyrotropin-releasing factor, allowing CRH to regulate both the adrenal and thyroid axes, especially in development. Corticotropin-releasing factor binding protein (CRH-BP) is thought to play an inhibitory role in which it binds CRH and other CRH-like ligands and prevents the activation of CRH receptors. There is however evidence that CRH-BP may also exhibit diverse extra and intracellular roles in a cell specific fashion and at specific times in development.[1] Human proteinsCRHBP; References1. ^{{cite journal |vauthors=Seasholtz AF, Valverde RA, Denver RJ |title=Corticotropin-releasing hormone-binding protein: biochemistry and function from fishes to mammals |journal=J. Endocrinol. |volume=175 |issue=1 |pages=89–97 |year=2002 |pmid=12379493 |doi=10.1677/joe.0.1750089}} {{InterPro content|IPR008435}} 1 : Protein domains |
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