| 释义 |
- References
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{{Infobox_gene}}Cytochrome c oxidase polypeptide 7A1, mitochondrial is an enzyme that in humans is encoded by the COX7A1 gene.[1][2][3]Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes polypeptide 1 (muscle isoform) of subunit VIIa and the polypeptide 1 is present only in muscle tissues. Other polypeptides of subunit VIIa are present in both muscle and nonmuscle tissues, and are encoded by different genes.[3]References1. ^{{cite journal | vauthors = Arnaudo E, Hirano M, Seelan RS, Milatovich A, Hsieh CL, Fabrizi GM, Grossman LI, Francke U, Schon EA | title = Tissue-specific expression and chromosome assignment of genes specifying two isoforms of subunit VIIa of human cytochrome c oxidase | journal = Gene | volume = 119 | issue = 2 | pages = 299–305 |date=Nov 1992 | pmid = 1327965 | pmc = | doi =10.1016/0378-1119(92)90287-Y }}
2. ^{{cite journal | vauthors = Fabrizi GM, Rizzuto R, Nakase H, Mita S, Lomax MI, Grossman LI, Schon EA | title = Sequence of a cDNA specifying subunit VIIa of human cytochrome c oxidase | journal = Nucleic Acids Res | volume = 17 | issue = 17 | pages = 7107–7107 |date=Oct 1989 | pmid = 2550906 | pmc = 318441 | doi =10.1093/nar/17.17.7107 }}
3. ^1 {{cite web | title = Entrez Gene: COX7A1 cytochrome c oxidase subunit VIIa polypeptide 1 (muscle)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1346| accessdate = }}
External links- {{UCSC gene info|COX7A1}}
Further reading{{refbegin | 2}}- {{cite journal | vauthors=Lenka N, Vijayasarathy C, Mullick J, Avadhani NG |title=Structural organization and transcription regulation of nuclear genes encoding the mammalian cytochrome c oxidase complex |journal=Prog. Nucleic Acid Res. Mol. Biol. |volume=61 |issue= |pages= 309–344 |year= 1998 |pmid= 9752724 |doi=10.1016/S0079-6603(08)60830-2 | series=Progress in Nucleic Acid Research and Molecular Biology | isbn=978-0-12-540061-9 }}
- {{cite journal | vauthors=Van Kuilenburg AB, Van Beeumen JJ, Van der Meer NM, Muijsers AO |title=Subunits VIIa,b,c of human cytochrome c oxidase. Identification of both 'heart-type' and 'liver-type' isoforms of subunit VIIa in human heart |journal=Eur. J. Biochem. |volume=203 |issue= 1–2 |pages= 193–199 |year= 1992 |pmid= 1309697 |doi=10.1111/j.1432-1033.1992.tb19847.x }}
- {{cite journal | vauthors=Wolz W, Kress W, Mueller CR |title=Genomic sequence and organization of the human gene for cytochrome c oxidase subunit (COX7A1) VIIa-M |journal=Genomics |volume=45 |issue= 2 |pages= 438–442 |year= 1998 |pmid= 9344674 |doi= 10.1006/geno.1997.4937 }}
- {{cite journal | vauthors=Schmidt TR, Goodman M, Grossman LI |title=Molecular evolution of the COX7A gene family in primates |journal=Mol. Biol. Evol. |volume=16 |issue= 5 |pages= 619–26 |year= 1999 |pmid= 10335655 |doi= 10.1093/oxfordjournals.molbev.a026144}}
- {{cite journal | vauthors=Yu M, Jaradat SA, Grossman LI |title=Genomic organization and promoter regulation of human cytochrome c oxidase subunit VII heart/muscle isoform (COX7AH) |journal=Biochim. Biophys. Acta |volume=1574 |issue= 3 |pages= 345–53 |year= 2002 |pmid= 11997101 |doi= 10.1016/s0167-4781(02)00228-2}}
- {{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–16903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |name-list-format=vanc| author2=Feingold EA | author3=Grouse LH | display-authors=3 | last4=Derge | first4=JG | last5=Klausner | first5=RD | last6=Collins | first6=FS | last7=Wagner | first7=L | last8=Shenmen | first8=CM | last9=Schuler | first9=GD }}
- {{cite journal | author=Grimwood J |title=The DNA sequence and biology of human chromosome 19 |journal=Nature |volume=428 |issue= 6982 |pages= 529–535 |year= 2004 |pmid= 15057824 |doi= 10.1038/nature02399 |name-list-format=vanc| author2=Gordon LA | author3=Olsen A | display-authors=3 | last4=Terry | first4=Astrid | last5=Schmutz | first5=Jeremy | last6=Lamerdin | first6=Jane | last7=Hellsten | first7=Uffe | last8=Goodstein | first8=David | last9=Couronne | first9=Olivier }}
- {{cite journal | author=Gerhard DS |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–2127 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |name-list-format=vanc| author2=Wagner L | author3=Feingold EA | display-authors=3 | last4=Shenmen | first4=CM | last5=Grouse | first5=LH | last6=Schuler | first6=G | last7=Klein | first7=SL | last8=Old | first8=S | last9=Rasooly | first9=R }}
{{refend}}{{gene-19-stub}} |