| 释义 |
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{{Infobox_gene}}Cytochrome c oxidase polypeptide 7A2, mitochondrial is an enzyme that in humans is encoded by the COX7A2 gene.[1][2][3]Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes polypeptide 2 (liver isoform) of subunit VIIa and the polypeptide 2 is present in both muscle and nonmuscle tissues. In addition to polypeptide 2, subunit VIIa includes polypeptide 1 (muscle isoform), which is present only in muscle tissues, and a related protein, present in all tissues. This gene may have several pseudogenes.[3]References1. ^{{cite journal | vauthors = Arnaudo E, Hirano M, Seelan RS, Milatovich A, Hsieh CL, Fabrizi GM, Grossman LI, Francke U, Schon EA | title = Tissue-specific expression and chromosome assignment of genes specifying two isoforms of subunit VIIa of human cytochrome c oxidase | journal = Gene | volume = 119 | issue = 2 | pages = 299–305 |date=Nov 1992 | pmid = 1327965 | pmc = | doi =10.1016/0378-1119(92)90287-Y }}
2. ^{{cite journal | vauthors = Merante F, Duncan AM, Mitchell G, Duff C, Rommens J, Robinson BH | title = Chromosomal localization of the human liver form cytochrome c oxidase subunit VIIa gene | journal = Genome | volume = 40 | issue = 3 | pages = 318–24 |date=Aug 1997 | pmid = 9202412 | pmc = | doi =10.1139/g97-044 }}
3. ^1 {{cite web | title = Entrez Gene: COX7A2 cytochrome c oxidase subunit VIIa polypeptide 2 (liver)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1347| accessdate = }}
External links- {{UCSC gene info|COX7A2}}
Further reading{{refbegin | 2}}- {{cite journal | vauthors=Lenka N, Vijayasarathy C, Mullick J, Avadhani NG | title=Structural Organization and Transcription Regulation of Nuclear Genes Encoding the Mammalian Cytochrome c Oxidase Complex |journal=Prog. Nucleic Acid Res. Mol. Biol. |volume=61 |issue= |pages= 309–44 |year= 1998 |pmid= 9752724 |doi=10.1016/S0079-6603(08)60830-2 | series=Progress in Nucleic Acid Research and Molecular Biology | isbn=978-0-12-540061-9 }}
- {{cite journal | vauthors=Van Kuilenburg AB, Van Beeumen JJ, Van der Meer NM, Muijsers AO |title=Subunits VIIa,b,c of human cytochrome c oxidase. Identification of both 'heart-type' and 'liver-type' isoforms of subunit VIIa in human heart |journal=Eur. J. Biochem. |volume=203 |issue= 1–2 |pages= 193–9 |year= 1992 |pmid= 1309697 |doi=10.1111/j.1432-1033.1992.tb19847.x }}
- {{cite journal | vauthors=Fabrizi GM, Rizzuto R, Nakase H |title=Sequence of a cDNA specifying subunit VIIa of human cytochrome c oxidase |journal=Nucleic Acids Res. |volume=17 |issue= 17 |pages= 7107 |year= 1989 |pmid= 2550906 |doi=10.1093/nar/17.17.7107 | pmc=318441 |display-authors=etal}}
- {{cite journal | vauthors=Taanman JW, Hall RE, Tang C |title=Tissue distribution of cytochrome c oxidase isoforms in mammals. Characterization with monoclonal and polyclonal antibodies |journal=Biochim. Biophys. Acta |volume=1225 |issue= 1 |pages= 95–100 |year= 1993 |pmid= 8241294 |doi= 10.1016/0925-4439(93)90128-n|display-authors=etal}}
- {{cite journal | vauthors=Merante F, Ling M, Duncan AM |title=Cloning, characterization, and chromosomal localization of human liver form cytochrome c oxidase subunit VIa related genes |journal=Genome |volume=40 |issue= 3 |pages= 325–31 |year= 1997 |pmid= 9202413 |doi=10.1139/g97-045 |display-authors=etal}}
- {{cite journal | vauthors=Hüttemann M, Mühlenbein N, Schmidt TR |title=Isolation and sequence of the human cytochrome c oxidase subunit VIIaL gene |journal=Biochim. Biophys. Acta |volume=1492 |issue= 1 |pages= 252–8 |year= 2000 |pmid= 11004498 |doi= 10.1016/s0167-4781(00)00087-7|display-authors=etal}}
- {{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
- {{cite journal | vauthors=Mungall AJ, Palmer SA, Sims SK |title=The DNA sequence and analysis of human chromosome 6 |journal=Nature |volume=425 |issue= 6960 |pages= 805–11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055 |display-authors=etal}}
- {{cite journal | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
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