| 释义 |
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{{Underlinked|date=May 2016}}{{Infobox_gene}}Cytochrome c oxidase subunit 7C, mitochondrial is an enzyme that in humans is encoded by the COX7C gene.[1][2]Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes subunit VIIc, which shares 87% and 85% amino acid sequence identity with mouse and bovine COX VIIc, respectively, and is found in all tissues. A pseudogene COX7CP1 has been found on chromosome 13.[2] References1. ^{{cite journal | vauthors = Hofmann S, Lichtner P, Schuffenhauer S, Gerbitz KD, Meitinger T | title = Assignment of the human genes coding for cytochrome c oxidase subunits Va (COX5A), VIc (COX6C) and VIIc (COX7C) to chromosome bands 15q25, 8q22→q23 and 5q14 and of three pseudogenes (COX5AP1, COX6CP1, COX7CP1) to 14q22, 16p12 and 13q14→q21 by FISH and radiation hybrid mapping | journal = Cytogenet Cell Genet | volume = 83 | issue = 3-4 | pages = 226–7 |date=Mar 1999 | pmid = 10072584 | pmc = | doi =10.1159/000015185 }}
2. ^1 {{cite web | title = Entrez Gene: COX7C cytochrome c oxidase subunit VIIc| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1350| accessdate = }}
External linksFurther reading{{refbegin | 2}}- {{cite journal | vauthors=Lenka N, Vijayasarathy C, Mullick J, Avadhani NG |title=Structural organization and transcription regulation of nuclear genes encoding the mammalian cytochrome c oxidase complex. |journal=Prog. Nucleic Acid Res. Mol. Biol. |volume=61 |issue= |pages= 309–44 |year= 1998 |pmid= 9752724 |doi=10.1016/S0079-6603(08)60830-2 }}
- {{cite journal | vauthors=Sirchia R, Luparello C |title=Mid-region parathyroid hormone-related protein (PTHrP) and gene expression of MDA-MB231 breast cancer cells. |journal=Biol. Chem. |volume=388 |issue= 5 |pages= 457–65 |year= 2007 |pmid= 17516841 |doi= 10.1515/BC.2007.059 }}
- {{cite journal | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
- {{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
- {{cite journal | vauthors=Kaminishi H, Hamatake H, Cho T |title=Activation of blood clotting factors by microbial proteinases. |journal=FEMS Microbiol. Lett. |volume=121 |issue= 3 |pages= 327–32 |year= 1994 |pmid= 7926688 |doi=10.1111/j.1574-6968.1994.tb07121.x |display-authors=etal}}
- {{cite journal | vauthors=Koga Y, Fabrizi GM, Mita S |title=Sequence of a cDNA specifying subunit VIIc of human cytochrome c oxidase. |journal=Nucleic Acids Res. |volume=18 |issue= 3 |pages= 684 |year= 1990 |pmid= 2155413 |doi=10.1093/nar/18.3.684 | pmc=333506 |display-authors=etal}}
- {{cite journal | vauthors=Van Kuilenburg AB, Van Beeumen JJ, Van der Meer NM, Muijsers AO |title=Subunits VIIa,b,c of human cytochrome c oxidase. Identification of both 'heart-type' and 'liver-type' isoforms of subunit VIIa in human heart. |journal=Eur. J. Biochem. |volume=203 |issue= 1-2 |pages= 193–9 |year= 1992 |pmid= 1309697 |doi=10.1111/j.1432-1033.1992.tb19847.x }}
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