| 词条 | CP-226,269 |
| 释义 |
| Verifiedfields = changed | verifiedrevid = 459989884 | IUPAC_name = 5-fluoro-2-[(4-pyridin-2-ylpiperazin-1-yl)methyl]-1H-indole | image = CP-226269_structure.png | tradename = | licence_EU = | pregnancy_category = | legal_UK = | routes_of_administration = | bioavailability = | metabolism = | elimination_half-life = | excretion = | IUPHAR_ligand = 973 | CAS_number_Ref = {{cascite|changed|??}} | CAS_number = 220941-93-5 | ATC_suffix = | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | ChemSpiderID = 7972486 | StdInChI_Ref = {{stdinchicite|correct|chemspider}} | StdInChI = 1S/C18H19FN4/c19-15-4-5-17-14(11-15)12-16(21-17)13-22-7-9-23(10-8-22)18-3-1-2-6-20-18/h1-6,11-12,21H,7-10,13H2 | StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} | StdInChIKey = PQOIDBZLMJMYCD-UHFFFAOYSA-N | ChEMBL_Ref = {{ebicite|correct|EBI}} | ChEMBL = 77395 | PubChem = 9796720 | DrugBank_Ref = {{drugbankcite|correct|drugbank}} | C=18 | H=19 | F=1 | N=4 | molecular_weight = 310.368 g/mol | smiles = n4ccccc4N3CCN(CC3)Cc2cc1cc(F)ccc1[nH]2 }}CP-226,269 is a drug which acts as a dopamine agonist selective for the D4 subtype, which is used for researching the role of D4 receptors in the brain.[1][2] References1. ^{{cite journal |vauthors=Sharma A, Kramer ML, Wick PF, Liu D, Chari S, Shim S, Tan W, Ouellette D, Nagata M, DuRand CJ, Kotb M, Deth RC |title=D4 dopamine receptor-mediated phospholipid methylation and its implications for mental illnesses such as schizophrenia |journal=Molecular Psychiatry |volume=4 |issue=3 |pages=235–46 |date=May 1999 |pmid=10395213 |doi= 10.1038/sj.mp.4000522|url=}} {{Dopaminergics}}{{DEFAULTSORT:Cp-226, 269}}{{nervous-system-drug-stub}}2. ^{{cite journal |vauthors=Basso AM, Gallagher KB, Bratcher NA, Brioni JD, Moreland RB, Hsieh GC, Drescher K, Fox GB, Decker MW, Rueter LE |title=Antidepressant-like effect of D(2/3) receptor-, but not D(4) receptor-activation in the rat forced swim test |journal=Neuropsychopharmacology |volume=30 |issue=7 |pages=1257–68 |date=July 2005 |pmid=15688083 |doi=10.1038/sj.npp.1300677 |url=}} 7 : Dopamine agonists|Fluoroarenes|Indoles|Piperazines|Pyridines|Pfizer|Pfizer products |
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