| 词条 | CP-809101 |
| 释义 |
| Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 451224368 | IUPAC_name = 2-[(3-Chlorophenyl)methoxy]-6-(1-piperazinyl)pyrazine | image = CP-809,101_structure.png | width = 220 | tradename = | pregnancy_AU = | pregnancy_US = | pregnancy_category = | legal_AU = | legal_CA = | legal_UK = | legal_US = | legal_status = | routes_of_administration = | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion = | CAS_number_Ref = {{cascite|correct|??}} | CAS_number = 479683-64-2 | ATC_prefix = None | ATC_suffix = | PubChem = 9901086 | DrugBank = | ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}} | ChemSpiderID = 8076740 | C=15 | H=17 | Cl=1 | N=4 | O=1 | molecular_weight = 304.774 g/mol | smiles = C2CNCCN2c(n3)cncc3OCc(c1)cccc1Cl | StdInChI_Ref = {{stdinchicite|changed|chemspider}} | StdInChI = 1S/C15H17ClN4O/c16-13-3-1-2-12(8-13)11-21-15-10-18-9-14(19-15)20-6-4-17-5-7-20/h1-3,8-10,17H,4-7,11H2 | StdInChIKey_Ref = {{stdinchicite|changed|chemspider}} | StdInChIKey = PCWGGOVOEWHPMG-UHFFFAOYSA-N | melting_point = | melting_high = }}CP-809101 is a drug which acts as a potent and selective 5-HT2C receptor agonist.[1] It had promising results in animal models of obesity and psychosis, but associated with genotoxicity which means that future use will be restricted to scientific research applications only.[2][3] References1. ^{{cite journal |vauthors=Strong PV, Greenwood BN, Fleshner M |title=The effects of the selective 5-HT(2C) receptor antagonist SB 242084 on learned helplessness in male Fischer 344 rats |journal=Psychopharmacology |volume=203 |issue=4 |pages=665–75 |date=May 2009 |pmid=19037632 |doi=10.1007/s00213-008-1413-3 |url=}} {{Serotonergics}}{{nervous-system-drug-stub}}2. ^{{cite journal |vauthors=Siuciak JA, Chapin DS, McCarthy SA, Guanowsky V, Brown J, Chiang P, Marala R, Patterson T, Seymour PA, Swick A, Iredale PA |title=CP-809,101, a selective 5-HT2C agonist, shows activity in animal models of antipsychotic activity |journal=Neuropharmacology |volume=52 |issue=2 |pages=279–90 |date=February 2007 |pmid=16949622 |doi=10.1016/j.neuropharm.2006.07.024 |url=}} 3. ^{{cite journal |vauthors=Kalgutkar AS, Dalvie DK, Aubrecht J, Smith EB, Coffing SL, Cheung JR, Vage C, Lame ME, Chiang P, McClure KF, Maurer TS, Coelho RV, Soliman VF, Schildknegt K |title=Genotoxicity of 2-(3-chlorobenzyloxy)-6-(piperazinyl)pyrazine, a novel 5-hydroxytryptamine2c receptor agonist for the treatment of obesity: role of metabolic activation |journal=Drug Metabolism and Disposition |volume=35 |issue=6 |pages=848–58 |date=June 2007 |pmid=17344339 |doi=10.1124/dmd.106.013649 |url=}} 7 : Serotonin receptor agonists|Piperazines|Pyrimidines|Phenol ethers|Chloroarenes|Pfizer|Pfizer products |
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