| 词条 | CP-93129 |
| 释义 |
| IUPAC_name = 3-(1,2,3,6-tetrahydropyridin-4-yl)-1,4-dihydropyrrolo[3,2-b]pyridin-5-one | image = CP-93129_structure.png | width = 220 | tradename = | legal_status = | routes_of_administration = | metabolism = | elimination_half-life = | excretion = | IUPHAR_ligand = 11 | CAS_number = 127792-75-0 | PubChem = 124007 | ChemSpiderID = 110524 | C=12 | H=13 | N=3 | O=1 | molecular_weight = 215.251 g/mol | smiles = C3CNCC=C3c(c1n2)cnc1ccc2=O }}CP-93129 is a drug which acts as a potent and selective serotonin 5-HT1B receptor agonist, with approximately 150x and 200x selectivity over the closely related 5-HT1D and 5-HT1A receptors.[1] It is used in the study of 5-HT1B receptors in the brain, particularly their role in modulating the release of other neurotransmitters.[2][3][4][5] References1. ^Macor JE, Burkhart CA, Heym JH, Ives JL, Lebel LA, Newman ME, Nielsen JA, Ryan K, Schulz DW, Torgersen LK, et al. 3-(1,2,5,6-Tetrahydropyrid-4-yl)pyrrolo[3,2-b]pyrid-5-one: a potent and selective serotonin (5-HT1B) agonist and rotationally restricted phenolic analogue of 5-methoxy-3-(1,2,5,6-tetrahydropyrid-4-yl)indole. Journal of Medicinal Chemistry. 1990 Aug;33(8):2087-93. {{PMID|2374139}} {{Serotonergics}}{{nervous-system-drug-stub}}2. ^De Groote L, Olivier B, Westenberg HG. Role of 5-HT1B receptors in the regulation of extracellular serotonin and dopamine in the dorsal striatum of mice. European Journal of Pharmacology. 2003 Aug 22;476(1-2):71-7. {{PMID|12969751}} 3. ^Przegaliński E, Papla I, Siwanowicz J, Filip M. Effects of 5-HT1B receptor ligands microinjected into the ventral tegmental area on the locomotor and sensitizating effects of cocaine in rats. European Neuropsychopharmacology. 2004 May;14(3):217-25. {{PMID|15056481}} 4. ^Bramley JR, Sollars PJ, Pickard GE, Dudek FE. 5-HT1B receptor-mediated presynaptic inhibition of GABA release in the suprachiasmatic nucleus. Journal of Neurophysiology. 2005 Jun;93(6):3157-64. {{PMID|15716370}} 5. ^Saitow F, Murano M, Suzuki H. Modulatory effects of serotonin on GABAergic synaptic transmission and membrane properties in the deep cerebellar nuclei. Journal of Neurophysiology. 2009 Mar;101(3):1361-74. {{PMID|19144744}} 3 : Serotonin receptor agonists|Pfizer|Pfizer products |
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