| 词条 | CP-94253 |
| 释义 |
| Verifiedfields = changed | verifiedrevid = 449557319 | IUPAC_name = 3-(1,2,5,6-tetrahydro-4-pyridyl)-5-propoxypyrrolo[3,2-b]pyridine | image = CP-94253_structure.png | width = 220 | tradename = | legal_status = | routes_of_administration = | metabolism = | elimination_half-life = | excretion = | IUPHAR_ligand = 3221 | CAS_number_Ref = {{cascite|correct|??}} | CAS_number = 131084-35-0 | PubChem = 4029677 | ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}} | ChemSpiderID = 3246572 | C=15 | H=19 | N=3 | O=1 | molecular_weight = 257.330 g/mol | smiles = c13nc(OCCC)ccc1[nH]cc3C2=CCNCC2 | StdInChI_Ref = {{stdinchicite|changed|chemspider}} | StdInChI = 1S/C15H19N3O/c1-2-9-19-14-4-3-13-15(18-14)12(10-17-13)11-5-7-16-8-6-11/h3-5,10,16-17H,2,6-9H2,1H3 | StdInChIKey_Ref = {{stdinchicite|changed|chemspider}} | StdInChIKey = KWQWBZIGHIOKIO-UHFFFAOYSA-N }}CP-94253 is a drug which acts as a potent and selective serotonin 5-HT1B receptor agonist, with approximately 25x and 40x selectivity over the closely related 5-HT1D and 5-HT1A receptors.[1] It has a range of behavioural effects in animal studies, including promoting wakefulness by increasing dopamine release in the brain,[2][3] reducing food intake and promoting satiety,[4][5][6] enhancing the reinforcing effects of cocaine,[7][8][9][10] and possible antidepressant effects.[11] References1. ^Koe KB, Nielsen JA, Macor JE, Heym J. Biochemical and behavioral studies of the 5-HT1B receptor agonist, CP-94,253. Drug Development Research. 1992;26(3):241-250. {{doi|10.1002/ddr.430260305}} {{Serotonergics}}{{nervous-system-drug-stub}}2. ^Monti JM, Monti D, Jantos H, Ponzoni A. Effects of selective activation of the 5-HT1B receptor with CP-94,253 on sleep and wakefulness in the rat. Neuropharmacology. 1995 Dec;34(12):1647-51. {{PMID|8788962}} 3. ^Iyer RN, Bradberry CW. Serotonin-mediated increase in prefrontal cortex dopamine release: pharmacological characterization. Journal of Pharmacology and Experimental Therapeutics. 1996 Apr;277(1):40-7. {{PMID|8613947}} 4. ^Halford JC, Blundell JE. The 5-HT1B receptor agonist CP-94,253 reduces food intake and preserves the behavioural satiety sequence. Physiology & Behavior. 1996 Sep;60(3):933-9. {{PMID|8873272}} 5. ^Lee MD, Simansky KJ. CP-94,253: a selective serotonin1B (5-HT1B) agonist that promotes satiety. Psychopharmacology. 1997 Jun;131(3):264-70. {{PMID|9203237}} 6. ^Lee MD, Kennett GA, Dourish CT, Clifton PG. 5-HT1B receptors modulate components of satiety in the rat: behavioural and pharmacological analyses of the selective serotonin1B agonist CP-94,253. Psychopharmacology. 2002 Oct;164(1):49-60. {{PMID|12373419}} 7. ^Parsons LH, Weiss F, Koob GF. Serotonin1B receptor stimulation enhances cocaine reinforcement. Journal of Neuroscience. 1998 Dec 1;18(23):10078-89. {{PMID|9822762}} 8. ^Przegalinski E, Filip M, Papla I, Siwanowicz J. Effect of serotonin (5-HT)1B receptor ligands on cocaine sensitization in rats. Behavioural Pharmacology. 2001 Apr;12(2):109-16. {{PMID|11396515}} 9. ^{{cite journal |vauthors=Przegaliński E, Gołda A, Frankowska M, Zaniewska M, Filip M |title=Effects of serotonin 5-HT1B receptor ligands on the cocaine- and food-maintained self-administration in rats |journal=European Journal of Pharmacology |volume=559 |issue=2-3 |pages=165–72 |date=March 2007 |pmid=17291490 |doi=10.1016/j.ejphar.2006.12.012 |url=}} 10. ^{{cite journal |vauthors=Przegaliński E, Gołda A, Filip M |title=Effects of serotonin (5-HT)(1B) receptor ligands on cocaine-seeking behavior in rats |journal=Pharmacological Reports : PR |volume=60 |issue=6 |pages=798–810 |year=2008 |pmid=19211971 |doi= |url=}} 11. ^Tatarczyńska E, Antkiewicz-Michaluk L, Kłodzińska A, Stachowicz K, Chojnacka-Wójcik E. Antidepressant-like effect of the selective 5-HT1B receptor agonist CP 94253: a possible mechanism of action. European Journal of Pharmacology. 2005 May 23;516(1):46-50. {{PMID|15913599}} 5 : Serotonin receptor agonists|Phenol ethers|Pyridines|Pfizer|Pfizer products |
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