| 词条 | CPK-MB test |
| 释义 |
| Name = CPK-MB test | Image = AMI bloodtests engl.png | Alt = | Caption = Kinetics of cardiac markers in myocardial infarction with or without reperfusion treatment. | DiseasesDB = | ICD10 = | ICD9 = | ICDO = | MedlinePlus = | eMedicine = | MeshID = | LOINC = {{LOINC|49551-5}}, {{LOINC|51506-4}}, {{LOINC|2154-3}}, {{LOINC|13969-1}}, {{LOINC|32673-6}}, {{LOINC|38482-6}} | HCPCSlevel2 = | Reference_range = }} The CPK-MB test is a cardiac marker[1] used to assist diagnoses of an acute myocardial infarction. It measures the blood level of CK-MB (creatine kinase-muscle/brain), the bound combination of two variants (isoenzymes CKM and CKB) of the enzyme phosphocreatine kinase. In some locations, the test has been superseded by the troponin test. However, recently, there have been improvements to the test that involve measuring the ratio of the CK-MB1 and CK-MB2 isoforms.[2] The newer test detects different isoforms of the B subunit specific to the myocardium whereas the older test detected the presence of cardiac-related isoenzyme dimers. Many cases of CK-MB levels exceeding the blood level of total CK have been reported, especially in newborns with cardiac malformations, especially ventricular septal defects. This reversal of ratios is in favor of pulmonary emboli or vasculitis. An autoimmune reaction creating a complex molecule of CK and IgG should be taken into consideration.[3] References1. ^{{cite journal |author=Guzy PM |title=Creatine phosphokinase-MB (CPK-MB) and the diagnosis of myocardial infarction |journal=West. J. Med. |volume=127 |issue=6 |pages=455–60 |date=December 1977 |pmid=339548 |pmc=1237914 |doi= |url=}} {{Blood tests}}2. ^{{cite web |url=http://emedicine.medscape.com/article/811905-overview |title=Use of Cardiac Markers in the Emergency Department: - eMedicine |format= |website= |accessdate=2009-01-10}} 3. ^{{cite journal |author1=Boucek RJ Jr |author2=Kasselberg AG |author3=Boerth RC |author4=Parrish MD |author5=Graham TP Jr |title=Myocardial injury in infants with congenital heart disease: evaluation by creatine kinase MB isoenzyme analysis |journal=Am J Cardiol |volume=50 |issue=1 |pages=129–35 |date=July 1982 |pmid=7090995 |pmc= |doi= 10.1016/0002-9149(82)90018-2|url=}} 2 : Blood tests|Cardiology |
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