“CRTC2”的意思、由来-开放百科全书

CRTC2, initially called TORC2, is a transcriptional coactivator for the transcription factor CREB and a central regulator of

References

1. ^{{cite web | title = Entrez Gene: CRTC2 CREB regulated transcription coactivator 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=200186| accessdate = }}
2. ^{{cite journal | vauthors = Iourgenko V, Zhang W, Mickanin C, Daly I, Jiang C, Hexham JM, Orth AP, Miraglia L, Meltzer J, Garza D, Chirn GW, McWhinnie E, Cohen D, Skelton J, Terry R, Yu Y, Bodian D, Buxton FP, Zhu J, Song C, Labow MA | title = Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 100 | issue = 21 | pages = 12147–52 | date = Oct 2003 | pmid = 14506290 | pmc = 218727 | doi = 10.1073/pnas.1932773100 }}
3. ^{{cite journal | vauthors = Conkright MD, Canettieri G, Screaton R, Guzman E, Miraglia L, Hogenesch JB, Montminy M | title = TORCs: transducers of regulated CREB activity | journal = Molecular Cell | volume = 12 | issue = 2 | pages = 413–23 | date = Aug 2003 | pmid = 14536081 | doi = 10.1016/j.molcel.2003.08.013 }}
4. ^{{cite journal | vauthors = Cheng A, Saltiel AR | title = More TORC for the gluconeogenic engine | journal = BioEssays | volume = 28 | issue = 3 | pages = 231–4 | date = Mar 2006 | pmid = 16479585 | doi = 10.1002/bies.20375 | citeseerx = 10.1.1.604.5745 }}
5. ^¹{{cite journal | vauthors = Screaton RA, Conkright MD, Katoh Y, Best JL, Canettieri G, Jeffries S, Guzman E, Niessen S, Yates JR, Takemori H, Okamoto M, Montminy M | title = The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector | journal = Cell | volume = 119 | issue = 1 | pages = 61–74 | date = Oct 2004 | pmid = 15454081 | doi = 10.1016/j.cell.2004.09.015 }}
6. ^{{cite journal | vauthors = Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D | title = Large-scale mapping of human protein-protein interactions by mass spectrometry | journal = Molecular Systems Biology | volume = 3 | issue = 1 | pages = 89 | year = 2007 | pmid = 17353931 | pmc = 1847948 | doi = 10.1038/msb4100134 }}

Further reading

{{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides | journal = Gene | volume = 138 | issue = 1–2 | pages = 171–4 | date = Jan 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}

{{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1–2 | pages = 149–56 | date = Oct 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }}

{{cite journal | vauthors = Iourgenko V, Zhang W, Mickanin C, Daly I, Jiang C, Hexham JM, Orth AP, Miraglia L, Meltzer J, Garza D, Chirn GW, McWhinnie E, Cohen D, Skelton J, Terry R, Yu Y, Bodian D, Buxton FP, Zhu J, Song C, Labow MA | title = Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 100 | issue = 21 | pages = 12147–52 | date = Oct 2003 | pmid = 14506290 | pmc = 218727 | doi = 10.1073/pnas.1932773100 }}

{{cite journal | vauthors = Conkright MD, Canettieri G, Screaton R, Guzman E, Miraglia L, Hogenesch JB, Montminy M | title = TORCs: transducers of regulated CREB activity | journal = Molecular Cell | volume = 12 | issue = 2 | pages = 413–23 | date = Aug 2003 | pmid = 14536081 | doi = 10.1016/j.molcel.2003.08.013 }}

{{cite journal | vauthors = Jin J, Smith FD, Stark C, Wells CD, Fawcett JP, Kulkarni S, Metalnikov P, O'Donnell P, Taylor P, Taylor L, Zougman A, Woodgett JR, Langeberg LK, Scott JD, Pawson T | title = Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization | journal = Current Biology | volume = 14 | issue = 16 | pages = 1436–50 | date = Aug 2004 | pmid = 15324660 | doi = 10.1016/j.cub.2004.07.051 }}

{{cite journal | vauthors = Screaton RA, Conkright MD, Katoh Y, Best JL, Canettieri G, Jeffries S, Guzman E, Niessen S, Yates JR, Takemori H, Okamoto M, Montminy M | title = The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector | journal = Cell | volume = 119 | issue = 1 | pages = 61–74 | date = Oct 2004 | pmid = 15454081 | doi = 10.1016/j.cell.2004.09.015 }}

{{cite journal | vauthors = Al-Hakim AK, Göransson O, Deak M, Toth R, Campbell DG, Morrice NA, Prescott AR, Alessi DR | title = 14-3-3 cooperates with LKB1 to regulate the activity and localization of QSK and SIK | journal = Journal of Cell Science | volume = 118 | issue = Pt 23 | pages = 5661–73 | date = Dec 2005 | pmid = 16306228 | doi = 10.1242/jcs.02670 }}

{{cite journal | vauthors = Siu YT, Chin KT, Siu KL, Yee Wai Choy E, Jeang KT, Jin DY | title = TORC1 and TORC2 coactivators are required for tax activation of the human T-cell leukemia virus type 1 long terminal repeats | journal = Journal of Virology | volume = 80 | issue = 14 | pages = 7052–9 | date = Jul 2006 | pmid = 16809310 | pmc = 1489057 | doi = 10.1128/JVI.00103-06 }}

{{cite journal | vauthors = Wu Z, Huang X, Feng Y, Handschin C, Feng Y, Gullicksen PS, Bare O, Labow M, Spiegelman B, Stevenson SC | title = Transducer of regulated CREB-binding proteins (TORCs) induce PGC-1alpha transcription and mitochondrial biogenesis in muscle cells | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 103 | issue = 39 | pages = 14379–84 | date = Sep 2006 | pmid = 16980408 | pmc = 1569674 | doi = 10.1073/pnas.0606714103 }}

{{cite journal | vauthors = Yang Q, Inoki K, Ikenoue T, Guan KL | title = Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity | journal = Genes & Development | volume = 20 | issue = 20 | pages = 2820–32 | date = Oct 2006 | pmid = 17043309 | pmc = 1619946 | doi = 10.1101/gad.1461206 }}

{{cite journal | vauthors = Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D | title = Large-scale mapping of human protein-protein interactions by mass spectrometry | journal = Molecular Systems Biology | volume = 3 | issue = 1 | pages = 89 | year = 2007 | pmid = 17353931 | pmc = 1847948 | doi = 10.1038/msb4100134 }}

{{cite journal | vauthors = Ravnskjaer K, Kester H, Liu Y, Zhang X, Lee D, Yates JR, Montminy M | title = Cooperative interactions between CBP and TORC2 confer selectivity to CREB target gene expression | journal = The EMBO Journal | volume = 26 | issue = 12 | pages = 2880–9 | date = Jun 2007 | pmid = 17476304 | pmc = 1894761 | doi = 10.1038/sj.emboj.7601715 }}

{{cite journal | vauthors = Kuraishy AI, French SW, Sherman M, Herling M, Jones D, Wall R, Teitell MA | title = TORC2 regulates germinal center repression of the TCL1 oncoprotein to promote B cell development and inhibit transformation | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 104 | issue = 24 | pages = 10175–80 | date = Jun 2007 | pmid = 17548807 | pmc = 1891214 | doi = 10.1073/pnas.0704170104 }}

Function

Interactions

References

Further reading

External links