| 词条 | Cruzipain |
| 释义 |
| Name = Cruzipain | EC_number = 3.4.22.51 | CAS_number = 141588-22-9 | IUBMB_EC_number = 3/4/22/51 | GO_code = | image = | width = | caption = }}Cruzipain is a cysteine protease expressed by Trypanosoma cruzi.[1] It is classified under {{EC number|3.4.22.51}}. Cruzipain is a sulfated glycoprotein which plays a role in the parasitic disease known as Chagas disease. It is found to aid the parasite in entering the host cell and in evading an immune response.[2] Cruzipain can help parasites escape the response from the adaptive immune system by interfering with the functions of immunoglobulins from the immunoglobin G subclasses.[3] These immunoglobulins are bound to receptors[4] and cruzipain interacts with these immunoglobulins by cleaving their hinges.[3] During smooth muscle cell invasion, cruzipain may cause receptors on [https://www.cvphysiology.com/Blood%20Flow/BF012.htm endothelin], a vasoconstrictor, to move around, which may interfer with the vasoconstrictor's ability to cause the blood vessels to become narrower.[3] References1. ^{{cite journal | vauthors = Lalmanach G, Boulangé A, Serveau C, Lecaille F, Scharfstein J, Gauthier F, Authié E | title = Congopain from Trypanosoma congolense: drug target and vaccine candidate | journal = Biological Chemistry | volume = 383 | issue = 5 | pages = 739–49 | date = May 2002 | pmid = 12108538 | doi = 10.1515/BC.2002.077 }} {{Cysteine proteases}}{{Enzymes}}{{Portal bar|Molecular and Cellular Biology|border=no}}{{biochemistry-stub}}2. ^{{cite journal | vauthors = Duschak VG, Couto AS | title = Cruzipain, the major cysteine protease of Trypanosoma cruzi: a sulfated glycoprotein antigen as relevant candidate for vaccine development and drug target. A review | journal = Current Medicinal Chemistry | volume = 16 | issue = 24 | pages = 3174–202 | date = 2009 | pmid = 19689291 }} 3. ^1 2 {{cite journal | vauthors = Uehara LA, Moreira OC, Oliveira AC, Azambuja P, Lima AP, Britto C, dos Santos AL, Branquinha MH, d'Avila-Levy CM | display-authors = 6 | title = Cruzipain promotes Trypanosoma cruzi adhesion to Rhodnius prolixus midgut | journal = PLoS Neglected Tropical Diseases | volume = 6 | issue = 12 | pages = e1958 | date = 2012-12-13 | pmid = 23272264 | pmc = 3521651 | doi = 10.1371/journal.pntd.0001958 }} 4. ^{{cite journal | vauthors = Vidarsson G, Dekkers G, Rispens T | title = IgG subclasses and allotypes: from structure to effector functions | journal = Frontiers in Immunology | volume = 5 | pages = 520 | date = 2014-10-20 | pmid = 25368619 | pmc = 4202688 | doi = 10.3389/fimmu.2014.00520 }} 1 : EC 3.4.22 |
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