1. References

2. External links

3. Further reading

The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions. This gene encodes a glycosylated cysteine protease inhibitor with a putative role in immune regulation through inhibition of a unique target in the hematopoietic system. Expression of the protein has been observed in various human cancer cell lines established from malignant tumors.^[4]

References

External links

• The MEROPS online database for peptidases and their inhibitors: I25.007
• {{UCSC gene info|CST7}}

Further reading

• {{cite journal | vauthors=Brown WM, Dziegielewska KM |title=Friends and relations of the cystatin superfamily--new members and their evolution. |journal=Protein Sci. |volume=6 |issue= 1 |pages= 5–12 |year= 1997 |pmid= 9007972 |doi=10.1002/pro.5560060102 | pmc=2143511 }}
• {{cite journal | vauthors=Saitoh E, Isemura S, Sanada K |title=Cystatin superfamily. Evidence that family II cystatin genes are evolutionarily related to family III cystatin genes. |journal=Biol. Chem. Hoppe-Seyler |volume=369 Suppl |issue= |pages= 191–7 |year= 1989 |pmid= 3202964 |doi= |display-authors=etal}}
• {{cite journal | vauthors=Thiesse M, Millar SJ, Dickinson DP |title=The human type 2 cystatin gene family consists of eight to nine members, with at least seven genes clustered at a single locus on human chromosome 20. |journal=DNA Cell Biol. |volume=13 |issue= 2 |pages= 97–116 |year= 1994 |pmid= 8179826 |doi=10.1089/dna.1994.13.97 }}
• {{cite journal | vauthors=Morita M, Yoshiuchi N, Arakawa H, Nishimura S |title=CMAP: a novel cystatin-like gene involved in liver metastasis. |journal=Cancer Res. |volume=59 |issue= 1 |pages= 151–8 |year= 1999 |pmid= 9892200 |doi= }}
• {{cite journal | vauthors=Morita M, Hara Y, Tamai Y |title=Genomic construct and mapping of the gene for CMAP (leukocystatin/cystatin F, CST7) and identification of a proximal novel gene, BSCv (C20orf3). |journal=Genomics |volume=67 |issue= 1 |pages= 87–91 |year= 2001 |pmid= 10945474 |doi= 10.1006/geno.2000.6237 |display-authors=etal}}
• {{cite journal | vauthors=Journet A, Chapel A, Kieffer S |title=Towards a human repertoire of monocytic lysosomal proteins. |journal=Electrophoresis |volume=21 |issue= 16 |pages= 3411–9 |year= 2001 |pmid= 11079561 |doi= 10.1002/1522-2683(20001001)21:16<3411::AID-ELPS3411>3.0.CO;2-M |display-authors=etal}}
• {{cite journal | vauthors=Deloukas P, Matthews LH, Ashurst J |title=The DNA sequence and comparative analysis of human chromosome 20. |journal=Nature |volume=414 |issue= 6866 |pages= 865–71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a |display-authors=etal}}
• {{cite journal | vauthors=Nathanson CM, Wassélius J, Wallin H, Abrahamson M |title=Regulated expression and intracellular localization of cystatin F in human U937 cells. |journal=Eur. J. Biochem. |volume=269 |issue= 22 |pages= 5502–11 |year= 2003 |pmid= 12423348 |doi=10.1046/j.1432-1033.2002.03252.x }}
• {{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
• {{cite journal | vauthors=Cappello F, Gatti E, Camossetto V |title=Cystatin F is secreted, but artificial modification of its C-terminus can induce its endocytic targeting. |journal=Exp. Cell Res. |volume=297 |issue= 2 |pages= 607–18 |year= 2004 |pmid= 15212960 |doi= 10.1016/j.yexcr.2004.03.048 |display-authors=etal}}
• {{cite journal | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
• {{cite journal | vauthors=Langerholc T, Zavasnik-Bergant V, Turk B |title=Inhibitory properties of cystatin F and its localization in U937 promonocyte cells. |journal=FEBS J. |volume=272 |issue= 6 |pages= 1535–45 |year= 2005 |pmid= 15752368 |doi= 10.1111/j.1742-4658.2005.04594.x |display-authors=etal}}
• {{cite journal | vauthors=Rual JF, Venkatesan K, Hao T |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |display-authors=etal}}
• {{cite journal | vauthors=Schüttelkopf AW, Hamilton G, Watts C, van Aalten DM |title=Structural basis of reduction-dependent activation of human cystatin F. |journal=J. Biol. Chem. |volume=281 |issue= 24 |pages= 16570–5 |year= 2006 |pmid= 16601115 |doi= 10.1074/jbc.M601033200 }}

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