| 释义 |
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{{Infobox_gene}}Cleavage stimulation factor 64 kDa subunit is a protein that in humans is encoded by the CSTF2 gene.[1][2]This gene encodes a nuclear protein with an RRM (RNA recognition motif) domain. The protein is a member of the cleavage stimulation factor (CSTF) complex that is involved in the 3' end cleavage and polyadenylation of pre-mRNAs. Specifically, this protein binds GU-rich elements within the 3'-untranslated region of mRNAs.[2] InteractionsCSTF2 has been shown to interact with CSTF3,[3] SUB1,[4] SYMPK,[3] BARD1[5][6] and BRCA1.[5][6] References1. ^{{cite journal | vauthors = Takagaki Y, MacDonald CC, Shenk T, Manley JL | title = The human 64-kDa polyadenylylation factor contains a ribonucleoprotein-type RNA binding domain and unusual auxiliary motifs | journal = Proc Natl Acad Sci U S A | volume = 89 | issue = 4 | pages = 1403–7 |date=March 1992 | pmid = 1741396 | pmc = 48459 | doi =10.1073/pnas.89.4.1403 | bibcode = 1992PNAS...89.1403T }}
2. ^1 {{cite web | title = Entrez Gene: CSTF2 cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1478| accessdate = }}
3. ^1 {{cite journal |last=Takagaki |first=Y |author2=Manley J L |date=March 2000 |title=Complex protein interactions within the human polyadenylation machinery identify a novel component |journal=Mol. Cell. Biol. |volume=20 |issue=5 |pages=1515–25 | issn = 0270-7306| pmid = 10669729 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1128/MCB.20.5.1515-1525.2000 |pmc=85326 }}
4. ^{{cite journal |last=Calvo |first=O |author2=Manley J L |date=May 2001 |title=Evolutionarily conserved interaction between CstF-64 and PC4 links transcription, polyadenylation, and termination |journal=Mol. Cell |volume=7 |issue=5 |pages=1013–23 | issn = 1097-2765| pmid = 11389848 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1016/S1097-2765(01)00236-2 }}
5. ^1 {{cite journal |last=Kleiman |first=F E |author2=Manley J L |date=March 2001 |title=The BARD1-CstF-50 interaction links mRNA 3' end formation to DNA damage and tumor suppression |journal=Cell |volume=104 |issue=5 |pages=743–53 | issn = 0092-8674| pmid = 11257228 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1016/S0092-8674(01)00270-7 }}
6. ^1 {{cite journal |last=Kleiman |first=F E |author2=Manley J L |date=September 1999 |title=Functional interaction of BRCA1-associated BARD1 with polyadenylation factor CstF-50 |journal=Science |volume=285 |issue=5433 |pages=1576–9 | issn = 0036-8075| pmid = 10477523 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1126/science.285.5433.1576 }}
External linksFurther reading{{refbegin | 2}}- {{cite journal | vauthors=Takagaki Y, Manley JL |title=A human polyadenylation factor is a G protein beta-subunit homologue |journal=J. Biol. Chem. |volume=267 |issue= 33 |pages= 23471–4 |year= 1992 |pmid= 1358884 |doi= }}
- {{cite journal | vauthors=Murthy KG, Manley JL |title=The 160-kD subunit of human cleavage-polyadenylation specificity factor coordinates pre-mRNA 3'-end formation |journal=Genes Dev. |volume=9 |issue= 21 |pages= 2672–83 |year= 1995 |pmid= 7590244 |doi=10.1101/gad.9.21.2672 }}
- {{cite journal | vauthors=Takagaki Y, Manley JL |title=A polyadenylation factor subunit is the human homologue of the Drosophila suppressor of forked protein |journal=Nature |volume=372 |issue= 6505 |pages= 471–4 |year= 1994 |pmid= 7984242 |doi= 10.1038/372471a0 |bibcode=1994Natur.372..471T }}
- {{cite journal | vauthors=Rüegsegger U, Beyer K, Keller W |title=Purification and characterization of human cleavage factor Im involved in the 3' end processing of messenger RNA precursors |journal=J. Biol. Chem. |volume=271 |issue= 11 |pages= 6107–13 |year= 1996 |pmid= 8626397 |doi=10.1074/jbc.271.11.6107 }}
- {{cite journal | vauthors=Schul W, Groenhout B, Koberna K |title=The RNA 3' cleavage factors CstF 64 kDa and CPSF 100 kDa are concentrated in nuclear domains closely associated with coiled bodies and newly synthesized RNA |journal=EMBO J. |volume=15 |issue= 11 |pages= 2883–92 |year= 1996 |pmid= 8654386 |doi= 10.1002/j.1460-2075.1996.tb00649.x| pmc=450226 |display-authors=etal}}
- {{cite journal | vauthors=Takagaki Y, Seipelt RL, Peterson ML, Manley JL |title=The polyadenylation factor CstF-64 regulates alternative processing of IgM heavy chain pre-mRNA during B cell differentiation |journal=Cell |volume=87 |issue= 5 |pages= 941–52 |year= 1997 |pmid= 8945520 |doi=10.1016/S0092-8674(00)82000-0 }}
- {{cite journal | vauthors=Takagaki Y, Manley JL |title=RNA recognition by the human polyadenylation factor CstF |journal=Mol. Cell. Biol. |volume=17 |issue= 7 |pages= 3907–14 |year= 1997 |pmid= 9199325 |doi= 10.1128/MCB.17.7.3907| pmc=232243 }}
- {{cite journal | vauthors=Martincic K, Campbell R, Edwalds-Gilbert G |title=Increase in the 64-kDa subunit of the polyadenylation/cleavage stimulatory factor during the G0 to S phase transition |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 19 |pages= 11095–100 |year= 1998 |pmid= 9736695 |doi=10.1073/pnas.95.19.11095 | pmc=21601 |display-authors=etal|bibcode=1998PNAS...9511095M}}
- {{cite journal | vauthors=Takagaki Y, Manley JL |title=Levels of polyadenylation factor CstF-64 control IgM heavy chain mRNA accumulation and other events associated with B cell differentiation |journal=Mol. Cell |volume=2 |issue= 6 |pages= 761–71 |year= 1999 |pmid= 9885564 |doi=10.1016/S1097-2765(00)80291-9 }}
- {{cite journal | vauthors=Kleiman FE, Manley JL |title=Functional interaction of BRCA1-associated BARD1 with polyadenylation factor CstF-50 |journal=Science |volume=285 |issue= 5433 |pages= 1576–9 |year= 1999 |pmid= 10477523 |doi=10.1126/science.285.5433.1576 }}
- {{cite journal | vauthors=Takagaki Y, Manley JL |title=Complex protein interactions within the human polyadenylation machinery identify a novel component |journal=Mol. Cell. Biol. |volume=20 |issue= 5 |pages= 1515–25 |year= 2000 |pmid= 10669729 |doi=10.1128/MCB.20.5.1515-1525.2000 | pmc=85326 }}
- {{cite journal | vauthors=Dass B, McMahon KW, Jenkins NA |title=The gene for a variant form of the polyadenylation protein CstF-64 is on chromosome 19 and is expressed in pachytene spermatocytes in mice |journal=J. Biol. Chem. |volume=276 |issue= 11 |pages= 8044–50 |year= 2001 |pmid= 11113135 |doi= 10.1074/jbc.M009091200 |display-authors=etal}}
- {{cite journal | vauthors=Kleiman FE, Manley JL |title=The BARD1-CstF-50 interaction links mRNA 3' end formation to DNA damage and tumor suppression |journal=Cell |volume=104 |issue= 5 |pages= 743–53 |year= 2001 |pmid= 11257228 |doi=10.1016/S0092-8674(01)00270-7 }}
- {{cite journal | vauthors=Calvo O, Manley JL |title=Evolutionarily conserved interaction between CstF-64 and PC4 links transcription, polyadenylation, and termination |journal=Mol. Cell |volume=7 |issue= 5 |pages= 1013–23 |year= 2001 |pmid= 11389848 |doi=10.1016/S1097-2765(01)00236-2 }}
- {{cite journal | vauthors=Bléoo S, Sun X, Hendzel MJ |title=Association of human DEAD box protein DDX1 with a cleavage stimulation factor involved in 3'-end processing of pre-MRNA |journal=Mol. Biol. Cell |volume=12 |issue= 10 |pages= 3046–59 |year= 2002 |pmid= 11598190 |doi= 10.1091/mbc.12.10.3046| pmc=60154 |display-authors=etal}}
- {{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal|bibcode=2002PNAS...9916899M }}
- {{cite journal | vauthors=Pérez Cañadillas JM, Varani G |title=Recognition of GU-rich polyadenylation regulatory elements by human CstF-64 protein |journal=EMBO J. |volume=22 |issue= 11 |pages= 2821–30 |year= 2003 |pmid= 12773396 |doi= 10.1093/emboj/cdg259 | pmc=156756 }}
- {{cite journal | vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal}}
- {{cite journal | vauthors=Xing H, Mayhew CN, Cullen KE |title=HSF1 modulation of Hsp70 mRNA polyadenylation via interaction with symplekin |journal=J. Biol. Chem. |volume=279 |issue= 11 |pages= 10551–5 |year= 2004 |pmid= 14707147 |doi= 10.1074/jbc.M311719200 |display-authors=etal}}
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