| 释义 |
- Interactions
- References
- External links
- Further reading
{{Infobox_gene}}RNA polymerase II subunit A C-terminal domain phosphatase is an enzyme that in humans is encoded by the CTDP1 gene.[1][2][3]This gene encodes a protein which interacts with the carboxy-terminus of transcription initiation factor TFIIF, a transcription factor which regulates elongation as well as initiation by RNA polymerase II. The protein may also represent a component of an RNA polymerase II holoenzyme complex. Alternative splicing of this gene results in two transcript variants encoding 2 different isoforms.[4] InteractionsCTDP1 has been shown to interact with WD repeat-containing protein 77,[5] GTF2F1[2] and POLR2A.[6] References1. ^{{cite journal | vauthors = Archambault J, Chambers RS, Kobor MS, Ho Y, Cartier M, Bolotin D, Andrews B, Kane CM, Greenblatt J | title = An essential component of a C-terminal domain phosphatase that interacts with transcription factor IIF in Saccharomyces cerevisiae | journal = Proc Natl Acad Sci U S A | volume = 94 | issue = 26 | pages = 14300–5 |date=Feb 1998 | pmid = 9405607 | pmc = 24951 | doi =10.1073/pnas.94.26.14300 | bibcode = 1997PNAS...9414300A }}
2. ^1 {{cite journal | vauthors = Archambault J, Pan G, Dahmus GK, Cartier M, Marshall N, Zhang S, Dahmus ME, Greenblatt J | title = FCP1, the RAP74-interacting subunit of a human protein phosphatase that dephosphorylates the carboxyl-terminal domain of RNA polymerase IIO | journal = J Biol Chem | volume = 273 | issue = 42 | pages = 27593–601 |date=Nov 1998 | pmid = 9765293 | pmc = | doi =10.1074/jbc.273.42.27593 }}
3. ^{{cite web | title = Entrez Gene: CTDP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9150| accessdate = }}
4. ^{{cite web | title = Entrez Gene: CTDP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9150| accessdate = }}
5. ^{{cite journal |last=Licciardo |first=Paolo |author2=Amente Stefano |author3=Ruggiero Luca |author4=Monti Maria |author5=Pucci Piero |author6=Lania Luigi |author7=Majello Barbara |date=Feb 2003 |title=The FCP1 phosphatase interacts with RNA polymerase II and with MEP50 a component of the methylosome complex involved in the assembly of snRNP |journal=Nucleic Acids Res. |volume=31 |issue=3 |pages=999–1005 |publisher= |location = England| issn = | pmid = 12560496 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1093/nar/gkg197 |pmc=149217 }}
6. ^{{cite journal |last=Scully |first=R |author2=Anderson S F |author3=Chao D M |author4=Wei W |author5=Ye L |author6=Young R A |author7=Livingston D M |author8=Parvin J D |date=May 1997 |title=BRCA1 is a component of the RNA polymerase II holoenzyme |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue=11 |pages=5605–10 |publisher= |location = UNITED STATES| issn = 0027-8424| pmid = 9159119 | bibcode =1997PNAS...94.5605S | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1073/pnas.94.11.5605 |pmc=20825 }}
External linksFurther reading{{refbegin | 2}}- {{cite journal | vauthors=Scully R, Anderson SF, Chao DM |title=BRCA1 is a component of the RNA polymerase II holoenzyme. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 11 |pages= 5605–10 |year= 1997 |pmid= 9159119 |doi=10.1073/pnas.94.11.5605 | pmc=20825 |display-authors=etal|bibcode=1997PNAS...94.5605S}}
- {{cite journal | vauthors=Marshall NF, Dahmus GK, Dahmus ME |title=Regulation of carboxyl-terminal domain phosphatase by HIV-1 tat protein. |journal=J. Biol. Chem. |volume=273 |issue= 48 |pages= 31726–30 |year= 1998 |pmid= 9822634 |doi=10.1074/jbc.273.48.31726 }}
- {{cite journal | vauthors=Cho H, Kim TK, Mancebo H |title=A protein phosphatase functions to recycle RNA polymerase II. |journal=Genes Dev. |volume=13 |issue= 12 |pages= 1540–52 |year= 1999 |pmid= 10385623 |doi=10.1101/gad.13.12.1540 | pmc=316795 |display-authors=etal}}
- {{cite journal | vauthors=Angelicheva D, Turnev I, Dye D |title=Congenital cataracts facial dysmorphism neuropathy (CCFDN) syndrome: a novel developmental disorder in Gypsies maps to 18qter. |journal=Eur. J. Hum. Genet. |volume=7 |issue= 5 |pages= 560–6 |year= 1999 |pmid= 10439962 |doi= 10.1038/sj.ejhg.5200319 |display-authors=etal}}
- {{cite journal | vauthors=Marshall NF, Dahmus ME |title=C-terminal domain phosphatase sensitivity of RNA polymerase II in early elongation complexes on the HIV-1 and adenovirus 2 major late templates. |journal=J. Biol. Chem. |volume=275 |issue= 42 |pages= 32430–7 |year= 2000 |pmid= 10938286 |doi= 10.1074/jbc.M005898200 }}
- {{cite journal | vauthors=Licciardo P, Napolitano G, Majello B, Lania L |title=Inhibition of Tat transactivation by the RNA polymerase II CTD-phosphatase FCP1. |journal=AIDS |volume=15 |issue= 3 |pages= 301–7 |year= 2001 |pmid= 11273209 |doi=10.1097/00002030-200102160-00002 }}
- {{cite journal | vauthors=Bharucha DC, Zhou M, Nekhai S |title=A protein phosphatase from human T cells augments tat transactivation of the human immunodeficiency virus type 1 long-terminal repeat. |journal=Virology |volume=296 |issue= 1 |pages= 6–16 |year= 2002 |pmid= 12036313 |doi= 10.1006/viro.2002.1438 |display-authors=etal}}
- {{cite journal | vauthors=Washington K, Ammosova T, Beullens M |title=Protein phosphatase-1 dephosphorylates the C-terminal domain of RNA polymerase-II. |journal=J. Biol. Chem. |volume=277 |issue= 43 |pages= 40442–8 |year= 2002 |pmid= 12185079 |doi= 10.1074/jbc.M205687200 |display-authors=etal}}
- {{cite journal | vauthors=Mandal SS, Cho H, Kim S |title=FCP1, a phosphatase specific for the heptapeptide repeat of the largest subunit of RNA polymerase II, stimulates transcription elongation. |journal=Mol. Cell. Biol. |volume=22 |issue= 21 |pages= 7543–52 |year= 2002 |pmid= 12370301 |doi=10.1128/MCB.22.21.7543-7552.2002 | pmc=135672 |display-authors=etal}}
- {{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal|bibcode=2002PNAS...9916899M }}
- {{cite journal | vauthors=Licciardo P, Amente S, Ruggiero L |title=The FCP1 phosphatase interacts with RNA polymerase II and with MEP50 a component of the methylosome complex involved in the assembly of snRNP. |journal=Nucleic Acids Res. |volume=31 |issue= 3 |pages= 999–1005 |year= 2003 |pmid= 12560496 |doi=10.1093/nar/gkg197 | pmc=149217 |display-authors=etal}}
- {{cite journal | vauthors=Nguyen BD, Chen HT, Kobor MS |title=Solution structure of the carboxyl-terminal domain of RAP74 and NMR characterization of the FCP1-binding sites of RAP74 and human TFIIB. |journal=Biochemistry |volume=42 |issue= 6 |pages= 1460–9 |year= 2003 |pmid= 12578358 |doi= 10.1021/bi0265473 |display-authors=etal}}
- {{cite journal | vauthors=Friedl EM, Lane WS, Erdjument-Bromage H |title=The C-terminal domain phosphatase and transcription elongation activities of FCP1 are regulated by phosphorylation. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 5 |pages= 2328–33 |year= 2003 |pmid= 12591939 |doi= 10.1073/pnas.2628049100 | pmc=151340 |display-authors=etal|bibcode=2003PNAS..100.2328F }}
- {{cite journal | vauthors=Kamada K, Roeder RG, Burley SK |title=Molecular mechanism of recruitment of TFIIF- associating RNA polymerase C-terminal domain phosphatase (FCP1) by transcription factor IIF. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 5 |pages= 2296–9 |year= 2003 |pmid= 12591941 |doi= 10.1073/pnas.262798199 | pmc=151334 |bibcode=2003PNAS..100.2296K }}
- {{cite journal | vauthors=Nguyen BD, Abbott KL, Potempa K |title=NMR structure of a complex containing the TFIIF subunit RAP74 and the RNA polymerase II carboxyl-terminal domain phosphatase FCP1. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 10 |pages= 5688–93 |year= 2003 |pmid= 12732728 |doi= 10.1073/pnas.1031524100 | pmc=156262 |display-authors=etal|bibcode=2003PNAS..100.5688N }}
- {{cite journal | vauthors=Varon R, Gooding R, Steglich C |title=Partial deficiency of the C-terminal-domain phosphatase of RNA polymerase II is associated with congenital cataracts facial dysmorphism neuropathy syndrome. |journal=Nat. Genet. |volume=35 |issue= 2 |pages= 185–9 |year= 2003 |pmid= 14517542 |doi= 10.1038/ng1243 |display-authors=etal}}
- {{cite journal | vauthors=Yu X, Chini CC, He M |title=The BRCT domain is a phospho-protein binding domain. |journal=Science |volume=302 |issue= 5645 |pages= 639–42 |year= 2003 |pmid= 14576433 |doi= 10.1126/science.1088753 |display-authors=etal|bibcode=2003Sci...302..639Y }}
- {{cite journal | vauthors=Beausoleil SA, Jedrychowski M, Schwartz D |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 | pmc=514446 |display-authors=etal|bibcode=2004PNAS..10112130B }}
{{refend}}{{PDB Gallery|geneid=9150}}{{gene-18-stub}} |