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词条 CTP synthase 1
释义

  1. Function

  2. References

  3. External links

  4. Further reading

{{Infobox_gene}}CTP synthase 1 is an enzyme that in human s is encoded by the CTPS gene.[1][2]

Function

The catalytic conversion of uridine triphosphate (UTP) to cytidine triphosphate (CTP) is accomplished by the enzyme cytidine-5-prime-triphosphate synthetase. This enzyme is important in the biosynthesis of phospholipids and nucleic acids, and plays a key role in cell growth, development, and tumorigenesis.[2]

References

1. ^{{cite journal | vauthors = Yamauchi M, Yamauchi N, Phear G, Spurr NK, Martinsson T, Weith A, Meuth M | title = Genomic organization and chromosomal localization of the human CTP synthetase gene (CTPS) | journal = Genomics | volume = 11 | issue = 4 | pages = 1088–96 |date=December 1991 | pmid = 1783378 | doi = 10.1016/0888-7543(91)90036-E| url = }}
2. ^1 {{cite web | title = Entrez Gene: CTP synthase| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1503| accessdate = }}

External links

  • {{UCSC gene info|CTPS1}}

Further reading

{{refbegin | 2}}
  • {{cite journal |vauthors=Thomas PE, Lamb BJ, Chu EH |title=Purification of cytidine-triphosphate synthetase from rat liver, and demonstration of monomer, dimer and tetramer. |journal=Biochim. Biophys. Acta |volume=953 |issue= 3 |pages= 334–44 |year= 1988 |pmid= 3355843 |doi=10.1016/0167-4838(88)90042-8 |url=https://deepblue.lib.umich.edu/bitstream/2027.42/27539/1/0000583.pdf }}
  • {{cite journal |vauthors=Jin J, Smith FD, Stark C |title=Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization |journal=Curr. Biol. |volume=14 |issue= 16 |pages= 1436–50 |year= 2004 |pmid= 15324660 |doi= 10.1016/j.cub.2004.07.051 |display-authors=etal}}
  • {{cite journal |vauthors=Verschuur AC, Van Gennip AH, Muller EJ |title=Cytidine triphosphate synthase activity and mRNA expression in normal human blood cells |journal=Biol. Chem. |volume=380 |issue= 1 |pages= 41–6 |year= 1999 |pmid= 10064135 |doi= 10.1515/BC.1999.005 |display-authors=etal}}
  • {{cite journal |vauthors=Yamauchi M, Yamauchi N, Meuth M |title=Molecular cloning of the human CTP synthetase gene by functional complementation with purified human metaphase chromosomes |journal=EMBO J. |volume=9 |issue= 7 |pages= 2095–9 |year= 1990 |pmid= 2113467 |pmc=551928 |doi= }}
  • {{cite journal |vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 |display-authors=etal}}
  • {{cite journal |vauthors=Gregory SG, Barlow KF, McLay KE |title=The DNA sequence and biological annotation of human chromosome 1 |journal=Nature |volume=441 |issue= 7091 |pages= 315–21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727 |display-authors=etal}}
  • {{cite journal |vauthors=Higgins MJ, Loiselle D, Haystead TA, Graves LM |title=Human cytidine triphosphate synthetase 1 interacting proteins |journal=Nucleosides Nucleotides Nucleic Acids |volume=27 |issue= 6 |pages= 850–7 |year= 2008 |pmid= 18600551 |doi= 10.1080/15257770802146502 }}
  • {{cite journal |vauthors=Olsen JV, Blagoev B, Gnad F |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 |display-authors=etal}}
  • {{cite journal |vauthors=Higgins MJ, Graves PR, Graves LM |title=Regulation of human cytidine triphosphate synthetase 1 by glycogen synthase kinase 3 |journal=J. Biol. Chem. |volume=282 |issue= 40 |pages= 29493–503 |year= 2007 |pmid= 17681942 |doi= 10.1074/jbc.M703948200 }}
  • {{cite journal |vauthors=Takahashi E, Yamauchi M, Tsuji H |title=Chromosome mapping of the human cytidine-5'-triphosphate synthetase (CTPS) gene to band 1p34.1-p34.3 by fluorescence in situ hybridization |journal=Hum. Genet. |volume=88 |issue= 1 |pages= 119–21 |year= 1991 |pmid= 1959918 |doi=10.1007/BF00204942 |display-authors=etal}}
  • {{cite journal |vauthors=Whelan J, Phear G, Yamauchi M, Meuth M |title=Clustered base substitutions in CTP synthetase conferring drug resistance in Chinese hamster ovary cells |journal=Nat. Genet. |volume=3 |issue= 4 |pages= 317–22 |year= 1993 |pmid= 7981751 |doi= 10.1038/ng0493-317 }}
  • {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |pmc=528928 |doi= 10.1101/gr.2596504 |display-authors=etal}}
  • {{cite journal |vauthors=Gevaert K, Staes A, Van Damme J |title=Global phosphoproteome analysis on human HepG2 hepatocytes using reversed-phase diagonal LC |journal=Proteomics |volume=5 |issue= 14 |pages= 3589–99 |year= 2005 |pmid= 16097034 |doi= 10.1002/pmic.200401217 |display-authors=etal}}
  • {{cite journal |vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
  • {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2002 |pmid= 12477932 |pmc=139241 |doi= 10.1073/pnas.242603899 |display-authors=etal}}
  • {{cite journal |vauthors=Han GS, Sreenivas A, Choi MG |title=Expression of Human CTP Synthetase in Saccharomyces cerevisiae Reveals Phosphorylation by Protein Kinase A |journal=J. Biol. Chem. |volume=280 |issue= 46 |pages= 38328–36 |year= 2005 |pmid= 16179339 |pmc=1400552 |doi= 10.1074/jbc.M509622200 |display-authors=etal}}
  • {{cite journal |vauthors=Beausoleil SA, Jedrychowski M, Schwartz D |title=Large-scale characterization of HeLa cell nuclear phosphoproteins |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |pmc=514446 |doi= 10.1073/pnas.0404720101 |display-authors=etal}}
  • {{cite journal |vauthors=Ewing RM, Chu P, Elisma F |title=Large-scale mapping of human protein–protein interactions by mass spectrometry |journal=Mol. Syst. Biol. |volume=3 |issue= 1|pages= 89 |year= 2007 |pmid= 17353931 |pmc=1847948 |doi= 10.1038/msb4100134 |display-authors=etal}}
  • {{cite journal |vauthors=Chang YF, Martin SS, Baldwin EP, Carman GM |title=Phosphorylation of Human CTP Synthetase 1 by Protein Kinase C IDENTIFICATION OF Ser462 AND Thr455 AS MAJOR SITES OF PHOSPHORYLATION |journal=J. Biol. Chem. |volume=282 |issue= 24 |pages= 17613–22 |year= 2007 |pmid= 17463002 |pmc=2081159 |doi= 10.1074/jbc.M702799200 }}
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