| 释义 |
- Clinical significance
- Interactions
- References
- Further reading
- External links
{{Infobox_gene}}Cullin-7 is a RING-E3 ligase protein that in humans is encoded by the CUL7 gene.[1][2][3] Clinical significance It is associated with 3-M syndrome. InteractionsCUL7 has been shown to interact with RBX1.[1] References1. ^1 {{cite journal | vauthors = Dias DC, Dolios G, Wang R, Pan ZQ | title = CUL7: A DOC domain-containing cullin selectively binds Skp1.Fbx29 to form an SCF-like complex | journal = Proc Natl Acad Sci U S A | volume = 99 | issue = 26 | pages = 16601–6 |date=Dec 2002 | pmid = 12481031 | pmc = 139190 | doi = 10.1073/pnas.252646399 }}
2. ^{{cite journal | vauthors = Arai T, Kasper JS, Skaar JR, Ali SH, Takahashi C, DeCaprio JA | title = Targeted disruption of p185/Cul7 gene results in abnormal vascular morphogenesis | journal = Proc Natl Acad Sci U S A | volume = 100 | issue = 17 | pages = 9855–60 |date=Aug 2003 | pmid = 12904573 | pmc = 187864 | doi = 10.1073/pnas.1733908100 }}
3. ^{{cite web | title = Entrez Gene: CUL7 cullin 7| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9820| accessdate = }}
Further reading{{refbegin | 2}}- {{cite journal | vauthors=Kim SS, Shago M, Kaustov L |title=CUL7 is a novel antiapoptotic oncogene. |journal=Cancer Res. |volume=67 |issue= 20 |pages= 9616–22 |year= 2007 |pmid= 17942889 |doi= 10.1158/0008-5472.CAN-07-0644 |display-authors=etal}}
- {{cite journal | vauthors=Jung P, Verdoodt B, Bailey A |title=Induction of cullin 7 by DNA damage attenuates p53 function. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=104 |issue= 27 |pages= 11388–93 |year= 2007 |pmid= 17586686 |doi= 10.1073/pnas.0609467104 | pmc=2040908 |display-authors=etal}}
- {{cite journal | vauthors=Skaar JR, Florens L, Tsutsumi T |title=PARC and CUL7 form atypical cullin RING ligase complexes. |journal=Cancer Res. |volume=67 |issue= 5 |pages= 2006–14 |year= 2007 |pmid= 17332328 |doi= 10.1158/0008-5472.CAN-06-3241 |display-authors=etal}}
- {{cite journal | vauthors=Kaustov L, Lukin J, Lemak A |title=The conserved CPH domains of Cul7 and PARC are protein-protein interaction modules that bind the tetramerization domain of p53. |journal=J. Biol. Chem. |volume=282 |issue= 15 |pages= 11300–7 |year= 2007 |pmid= 17298945 |doi= 10.1074/jbc.M611297200 |display-authors=etal}}
- {{cite journal | vauthors=Kasper JS, Arai T, DeCaprio JA |title=A novel p53-binding domain in CUL7. |journal=Biochem. Biophys. Res. Commun. |volume=348 |issue= 1 |pages= 132–8 |year= 2006 |pmid= 16875676 |doi= 10.1016/j.bbrc.2006.07.013 }}
- {{cite journal | vauthors=Andrews P, He YJ, Xiong Y |title=Cytoplasmic localized ubiquitin ligase cullin 7 binds to p53 and promotes cell growth by antagonizing p53 function. |journal=Oncogene |volume=25 |issue= 33 |pages= 4534–48 |year= 2006 |pmid= 16547496 |doi= 10.1038/sj.onc.1209490 }}
- {{cite journal | vauthors=Huber C, Dias-Santagata D, Glaser A |title=Identification of mutations in CUL7 in 3-M syndrome. |journal=Nat. Genet. |volume=37 |issue= 10 |pages= 1119–24 |year= 2005 |pmid= 16142236 |doi= 10.1038/ng1628 |display-authors=etal}}
- {{cite journal | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
- {{cite journal | vauthors=Mungall AJ, Palmer SA, Sims SK |title=The DNA sequence and analysis of human chromosome 6. |journal=Nature |volume=425 |issue= 6960 |pages= 805–11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055 |display-authors=etal}}
- {{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
- {{cite journal | vauthors=Nakayama M, Kikuno R, Ohara O |title=Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs. |journal=Genome Res. |volume=12 |issue= 11 |pages= 1773–84 |year= 2003 |pmid= 12421765 |doi= 10.1101/gr.406902 | pmc=187542 }}
- {{cite journal | vauthors=Winston JT, Koepp DM, Zhu C |title=A family of mammalian F-box proteins. |journal=Curr. Biol. |volume=9 |issue= 20 |pages= 1180–2 |year= 1999 |pmid= 10531037 |doi= 10.1016/S0960-9822(00)80021-4 |display-authors=etal}}
- {{cite journal | vauthors=Nomura N, Nagase T, Miyajima N |title=Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1. |journal=DNA Res. |volume=1 |issue= 5 |pages= 223–9 |year= 1995 |pmid= 7584044 |doi=10.1093/dnares/1.5.223 |display-authors=etal}}
{{refend}}External links- [https://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=gene&part=gr_3ms GeneReviews/NIH/NCBI/UW entry on 3-M syndrome]
- [https://www.ncbi.nlm.nih.gov/omim/273750,609577,610991,612921,273750,609577,610991,612921 OMIM entries entry on 3-M syndrome]
- {{UCSC gene info|CUL7}}
{{PDB Gallery|geneid=9820}}{{Cell cycle proteins}}{{gene-6-stub}} |