| 词条 | Cyanopindolol |
| 释义 |
| Verifiedfields = changed | verifiedrevid = 409199438 | IUPAC_name = (RS)-4-[3-(tert-Butylamino)-2-hydroxypropoxy]-1H-indole-2-carbonitrile | image = Cyanopindolol.svg | alt = Skeletal formula of cyanopindolol | image2 = Cyanopindolol-3D-spacefill.png | alt2 = Space-filling model of the cyanopindolol molecule | chirality = Racemic mixture | drug_name = | tradename = | pregnancy_AU = | pregnancy_US = | pregnancy_category = | legal_AU = | legal_CA = | legal_UK = | legal_US = | legal_status = | routes_of_administration = | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion = | CAS_number_Ref = {{cascite|correct|??}} | CAS_number = 69906-85-0 | ATC_prefix = none | ATC_suffix = | ATC_supplemental = | PubChem = 155346 | IUPHAR_ligand = 132 | DrugBank_Ref = {{drugbankcite|correct|drugbank}} | DrugBank = | ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}} | ChemSpiderID = 136847 | ChEMBL_Ref = {{ebicite|changed|EBI}} | ChEMBL = 378501 | chemical_formula = | C=16 | H=21 | N=3 | O=2 | molecular_weight = 287.36 g/mol | smiles = N#CC1=CC2=C(OCC(CNC(C)(C)C)O)C=CC=C2N1 | StdInChI_Ref = {{stdinchicite|changed|chemspider}} | StdInChI = 1S/C16H21N3O2/c1-16(2,3)18-9-12(20)10-21-15-6-4-5-14-13(15)7-11(8-17)19-14/h4-7,12,18-20H,9-10H2,1-3H3 | StdInChIKey_Ref = {{stdinchicite|changed|chemspider}} | StdInChIKey = QXIUMMLTJVHILT-UHFFFAOYSA-N }}Cyanopindolol is a drug related to pindolol which acts as both a β1 adrenoceptor antagonist and a 5-HT1A receptor antagonist. Its radiolabelled derivative iodocyanopindolol has been widely used in mapping the distribution of beta adrenoreceptors in the body.[1] References1. ^{{Cite journal |author1=Hoyer, D. |author2=Engel, G. | title = Binding of 125I-cyanopindolol to beta-1-adrenoceptors in a high and low affinity state | journal = Journal of Receptor Research | year = 1983 | volume = 3 | issue = 1–2 | pages = 45–59|pmid=6304308 }} {{Beta blockers}}{{Adrenergic receptor modulators}}{{Serotonin receptor modulators}}{{Antihypertensive-stub}} 6 : 5-HT1A antagonists|Alcohols|Beta blockers|Indoles|Nitriles|Phenol ethers |
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