| 词条 | Cycrimine |
| 释义 |
| IUPAC_name = 1-Cyclopentyl-1-phenyl-3-(piperidin-1-yl)propan-1-ol | image = Cycrimine.svg | width = | alt = | image2 = | width2 = | drug_name = | tradename = | licence_EU = | licence_US = Cycrimine | DailyMedID = | pregnancy_AU = | pregnancy_US = | pregnancy_category = | legal_AU = | legal_CA = | legal_UK = | legal_US = | legal_status = | dependency_liability = | routes_of_administration = | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion = | CAS_number = 77-39-4 | CAS_supplemental = | ATCvet = | ATC_prefix = none | ATC_suffix = | ATC_supplemental = | IUPHAR_ligand = | DrugBank = DB00942 | ChEBI_Ref = {{ebicite|correct|EBI}} | ChEBI = 59692 | UNII_Ref = {{fdacite|correct|FDA}} | UNII = 543567RFQQ | ChEMBL = 1201227 | synonyms = | PubChem = 2911 | ChemSpiderID = 2808 | StdInChI = 1S/C19H29NO/c21-19(18-11-5-6-12-18,17-9-3-1-4-10-17)13-16-20-14-7-2-8-15-20/h1,3-4,9-10,18,21H,2,5-8,11-16H2 | StdInChIKey = SWRUZBWLEWHWRI-UHFFFAOYSA-N | chemical_formula = | C=19 | H=29 | N=1 | O=1 | molecular_weight = 287.4 g/mol | SMILES = OC(CCN1CCCCC1)(C2CCCC2)c3ccccc3 | density = | melting_point = | melting_high = | melting_notes = | boiling_point = | boiling_notes = | solubility = | specific_rotation = | sec_combustion = }}Cycrimine (trade name Pagitane) is a central anticholinergic drug designed to reduce the levels of acetylcholine in the treatment of Parkinson's disease. Its mechanism of action is to bind to the muscarinic acetylcholine receptor M1.[1] SynthesisSee also
References1. ^Psychotropic Drugs and Related Compounds, 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972, page 218 2. ^{{cite journal|last1=Denton|first1=J. J.|last2=Schedl|first2=H. P.|last3=Lawson|first3=Virginia A.|last4=Neier|first4=W. B.|title=Antispasmodics. VII.1 Additional Morpholinyl and Piperidyl Tertiary Alcohols|journal=Journal of the American Chemical Society|volume=72|issue=8|year=1950|pages=3795–3796|doi=10.1021/ja01164a127}} External links
4 : Phenyl compounds|Piperidines|Antiparkinsonian agents|Cyclopentanes |
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