| 释义 |
- References
- External links
- Further reading
{{Infobox_gene}}Cytochrome P450 3A43 is a protein that in humans is encoded by the CYP3A43 gene.[1][2][3]This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This enzyme has a low level of testosterone hydroxylase activity. Although it bears homology to some drug-metabolizing cytochrome P450s, it is unknown whether the enzyme is also involved in xenobiotic metabolism. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Alternate splicing of this gene results in three transcript variants encoding different isoforms.[3] References1. ^{{cite journal | vauthors = Domanski TL, Finta C, Halpert JR, Zaphiropoulos PG | title = cDNA cloning and initial characterization of CYP3A43, a novel human cytochrome P450 | journal = Mol Pharmacol | volume = 59 | issue = 2 | pages = 386–92 |date=Feb 2001 | pmid = 11160876 | pmc = | doi = }}
2. ^{{cite journal | vauthors = Gellner K, Eiselt R, Hustert E, Arnold H, Koch I, Haberl M, Deglmann CJ, Burk O, Buntefuss D, Escher S, Bishop C, Koebe HG, Brinkmann U, Klenk HP, Kleine K, Meyer UA, Wojnowski L | title = Genomic organization of the human CYP3A locus: identification of a new, inducible CYP3A gene | journal = Pharmacogenetics | volume = 11 | issue = 2 | pages = 111–21 |date=Mar 2001 | pmid = 11266076 | pmc = | doi =10.1097/00008571-200103000-00002 }}
3. ^1 {{cite web | title = Entrez Gene: CYP3A43 cytochrome P450, family 3, subfamily A, polypeptide 43| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=64816| accessdate = }}
External links- {{UCSC gene info|CYP3A43}}
Further reading{{refbegin | 2}}- {{cite journal | vauthors=Smith G, Stubbins MJ, Harries LW, Wolf CR |title=Molecular genetics of the human cytochrome P450 monooxygenase superfamily |journal=Xenobiotica |volume=28 |issue= 12 |pages= 1129–65 |year= 1999 |pmid= 9890157 |doi=10.1080/004982598238868 }}
- {{cite journal | vauthors=Finta C, Zaphiropoulos PG |title=The human cytochrome P450 3A locus. Gene evolution by capture of downstream exons |journal=Gene |volume=260 |issue= 1–2 |pages= 13–23 |year= 2001 |pmid= 11137287 |doi=10.1016/S0378-1119(00)00470-4 }}
- {{cite journal | vauthors=Westlind A, Malmebo S, Johansson I |title=Cloning and tissue distribution of a novel human cytochrome p450 of the CYP3A subfamily, CYP3A43 |journal=Biochem. Biophys. Res. Commun. |volume=281 |issue= 5 |pages= 1349–55 |year= 2001 |pmid= 11243885 |doi= 10.1006/bbrc.2001.4505 |display-authors=etal}}
- {{cite journal | vauthors=Finta C, Zaphiropoulos PG |title=Intergenic mRNA molecules resulting from trans-splicing |journal=J. Biol. Chem. |volume=277 |issue= 8 |pages= 5882–90 |year= 2002 |pmid= 11726664 |doi= 10.1074/jbc.M109175200 }}
- {{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
- {{cite journal | vauthors=Hillier LW, Fulton RS, Fulton LA |title=The DNA sequence of human chromosome 7 |journal=Nature |volume=424 |issue= 6945 |pages= 157–64 |year= 2003 |pmid= 12853948 |doi= 10.1038/nature01782 |display-authors=etal}}
- {{cite journal | vauthors=Cauffiez C, Lo-Guidice JM, Chevalier D |title=First report of a genetic polymorphism of the cytochrome P450 3A43 (CYP3A43) gene: identification of a loss-of-function variant |journal=Hum. Mutat. |volume=23 |issue= 1 |pages= 101 |year= 2004 |pmid= 14695544 |doi= 10.1002/humu.9211 |display-authors=etal}}
- {{cite journal | vauthors=Hillman RT, Green RE, Brenner SE |title=An unappreciated role for RNA surveillance |journal=Genome Biol. |volume=5 |issue= 2 |pages= R8 |year= 2005 |pmid= 14759258 |doi= 10.1186/gb-2004-5-2-r8 | pmc=395752 }}
- {{cite journal | vauthors=Stone A, Ratnasinghe LD, Emerson GL |title=CYP3A43 Pro(340)Ala polymorphism and prostate cancer risk in African Americans and Caucasians |journal=Cancer Epidemiol. Biomarkers Prev. |volume=14 |issue= 5 |pages= 1257–61 |year= 2005 |pmid= 15894682 |doi= 10.1158/1055-9965.EPI-04-0534 |display-authors=etal}}
- {{cite journal | vauthors=Thompson EE, Kuttab-Boulos H, Yang L |title=Sequence diversity and haplotype structure at the human CYP3A cluster |journal=Pharmacogenomics J. |volume=6 |issue= 2 |pages= 105–14 |year= 2006 |pmid= 16314882 |doi= 10.1038/sj.tpj.6500347 |display-authors=etal}}
- {{cite journal | vauthors=Shchepotina EG, Nikishina MV, Vavilin VA, Lyakhovich VV |title=Analysis of restriction fragment length polymorphism of cytochrome P450 3A43 gene and evaluation of the incidence of CYP3A431B allele in europeoid residents of West Siberia |journal=Bull. Exp. Biol. Med. |volume=140 |issue= 6 |pages= 726–8 |year= 2006 |pmid= 16848237 |doi=10.1007/s10517-006-0067-6 }}
{{refend}}{{Cytochrome P450}}{{gene-7-stub}} |