| 词条 | Cyprodime |
| 释义 |
| Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 410884288 | IUPAC_name = (–)-N-(Cyclopropylmethyl)-4,14-dimethoxymorphinan-6-one | image = Cyprodime.svg | alt = Structural formula | width = 200 | image2 = Cyprodime molecule ball.png | alt2 = Ball-and-stick model | width2 = 210 | tradename = | pregnancy_AU = | pregnancy_US = | pregnancy_category = | legal_AU = | legal_CA = | legal_UK = | legal_US = | legal_status = | routes_of_administration = | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion = | CAS_number_Ref = {{cascite|correct|??}} | CAS_number = 118111-54-9 | ATC_prefix = none | ATC_suffix = | PubChem = 5748293 | DrugBank_Ref = {{drugbankcite|correct|drugbank}} | DrugBank = | ChEMBL_Ref = {{ebicite|changed|EBI}} | ChEMBL = 322796 | ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}} | ChemSpiderID = 20133376 | smiles = O=C4CC[C@@]3(OC)[C@@H]2N(CC[C@]3(c1c(cccc1OC)C2)C4)CC5CC5 | StdInChI_Ref = {{stdinchicite|changed|chemspider}} | StdInChI = 1S/C22H29NO3/c1-25-18-5-3-4-16-12-19-22(26-2)9-8-17(24)13-21(22,20(16)18)10-11-23(19)14-15-6-7-15/h3-5,15,19H,6-14H2,1-2H3/t19-,21-,22+/m0/s1 | StdInChIKey_Ref = {{stdinchicite|changed|chemspider}} | StdInChIKey = INUCRGMCKDQKNA-ILWGZMRPSA-N | C=22 | H=29 | N=1 | O=3 | molecular_weight = 355.471 g/mol | synonyms = Cyprodime }} Cyprodime is an opioid antagonist from the morphinan family of drugs. Cyprodime is a selective opioid antagonist which blocks the μ-opioid receptor,[1] but without affecting the δ-opioid or κ-opioid receptors. This makes it useful for scientific research as it allows the μ-opioid receptor to be selectively deactivated so that the actions of the δ and κ receptors can be studied separately, in contrast to better known opioid antagonists such as naloxone which block all three opioid receptor subtypes.[2] See also
References1. ^Schmidhammer H, Burkard WP, Eggstein-Aeppli L, Smith CF. Synthesis and biological evaluation of 14-alkoxymorphinans. 2. (−)-N- (cyclopropylmethyl)- 4,14-dimethoxymorphinan- 6-one, a selective mu opioid receptor antagonist. Journal of Medicinal Chemistry. 1989 Feb;32(2):418-21. {{PMID|2536439}} {{Opioidergics}}{{analgesic-stub}}2. ^Márki A, Monory K, Otvös F, Tóth G, Krassnig R, Schmidhammer H, Traynor JR, Roques BP, Maldonado R, Borsodi A. Mu-opioid receptor specific antagonist cyprodime: characterization by in vitro radioligand and [35S]GTPgammaS binding assays. European Journal of Pharmacology. 1999 Oct 27;383(2):209-14. {{PMID|10585536}} 6 : Synthetic opioids|Morphinans|Opioid antagonists|Ketones|Ethers|Phenol ethers |
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