“Cytomegalic inclusion body disease”的意思、由来-开放百科全书

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Cytomegalic inclusion body disease

释义

Presentation
References

Cytomegalic inclusion body disease (CIBD) is a series of signs and symptoms caused by cytomegalovirus infection, toxoplasmosis or other rare infections such as herpes or rubella viruses. It can produce massive calcification of the central nervous system, and often the kidneys.^[1]

Cytomegalic inclusion body disease is the most common cause of congenital abnormalities in the United States. It can also cause pneumonia and other diseases in immunocompromised patients, such as those with HIV/AIDS or recipients of organ transplants.^[2]

Presentation

Various systems are affected.

CNS abnormalities – microcephaly, intellectual disability, spasticity, epilepsy, periventricular calcification
Eye – choroidoretinitis and optic atrophy
Ear – sensorineural deafness
Liver – hepatosplenomegaly and jaundice due to hepatitis
Lung – pneumonitis (interstitial pneumonitis)
Heart – myocarditis
Thrombocytopenic purpura,haemolytic anaemia
GI diseases in AIDS patients
Late sequelae in individuals asymptomatic at birth – hearing defects and reduced intelligence

The cells of the infected organ show intranuclear inclusion giving the nucleus classical owls eye appearance.

Further tests like ELISA can be used to detect the antigen.

The cells of the infected organ show intranuclear inclusion giving the nucleus classical owls eye appearance.

Further tests like ELISA can be used to detect the antigen.Virus can be grown in cell culture also.

References

1. ^{{cite journal |vauthors=Marquis JR, Lee JK |title=Extensive central nervous system calcification in a stillborn male infant due to cytomegalovirus infection |journal=AJR. American Journal of Roentgenology |volume=127 |issue=4 |pages=665–7 |date=October 1976 |pmid=184717 |doi= 10.2214/ajr.127.4.665|url=http://www.ajronline.org/cgi/pmidlookup?view=long&pmid=184717 |issn= |accessdate=2008-10-17}}
2. ^{{cite book|title=Review of Medical Microbiology and Immunology|last=Levinson|first=Warren|edition=12th|publisher=McGraw-Hill|year=2012|isbn=978-0071774345}}

2 : Viral infections of the central nervous system|Cytomegalovirus-associated diseases

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