| 词条 | DAA-1097 |
| 释义 |
| verifiedrevid = 424726145 | IUPAC_name = N-(4-chloro-2-phenoxyphenyl)-N-(2-isopropoxybenzyl)acetamide | image = DAA-1097_structure.png | width = 200 | tradename = | pregnancy_category = | routes_of_administration = | bioavailability = | metabolism = | elimination_half-life = | excretion = | CAS_number = 220551-79-1 | ATC_prefix = | PubChem = 9844410 | DrugBank_Ref = {{drugbankcite|correct|drugbank}} | DrugBank = | ChemSpiderID = 8020125 | StdInChI = 1S/C24H24ClNO3/c1-17(2)28-23-12-8-7-9-19(23)16-26(18(3)27)22-14-13-20(25)15-24(22)29-21-10-5-4-6-11-21/h4-15,17H,16H2,1-3H3 | StdInChIKey = CGUBOFYHGYNUDL-UHFFFAOYSA-N | C=24 | H=24 | Cl=1 | N=1 | O=3 | molecular_weight = 409.904 g/mol | smiles = CC(C)Oc2ccccc2CN(C(=O)C)c1ccc(Cl)cc1Oc3ccccc3 }}DAA-1097 is a drug which acts as a potent and selective agonist at the peripheral benzodiazepine receptor, also known as the mitochondrial 18 kDa translocator protein or TSPO, but with no affinity at central benzodiazepine receptors. It has anxiolytic effects in animal studies.[1][2][3] References1. ^{{cite journal |vauthors=Okuyama S, Chaki S, Yoshikawa R, Ogawa S, Suzuki Y, Okubo T, Nakazato A, Nagamine M, Tomisawa K |title=Neuropharmacological profile of peripheral benzodiazepine receptor agonists, DAA1097 and DAA1106 |journal=Life Sciences |volume=64 |issue=16 |pages=1455–64 |year=1999 |pmid=10321725 |doi= 10.1016/S0024-3205(99)00079-X|url=}} {{Anxiolytics}}{{nervous-system-drug-stub}}2. ^{{cite journal |vauthors=Okubo T, Yoshikawa R, Chaki S, Okuyama S, Nakazato A |title=Design, synthesis and structure-affinity relationships of aryloxyanilide derivatives as novel peripheral benzodiazepine receptor ligands |journal=Bioorganic & Medicinal Chemistry |volume=12 |issue=2 |pages=423–38 |date=January 2004 |pmid=14723961 |doi= 10.1016/j.bmc.2003.10.050|url=}} 3. ^{{cite journal |vauthors=James ML, Selleri S, Kassiou M |title=Development of ligands for the peripheral benzodiazepine receptor |journal=Current Medicinal Chemistry |volume=13 |issue=17 |pages=1991–2001 |year=2006 |pmid=16842193 |doi= 10.2174/092986706777584979|url=}} 5 : Anxiolytics|TSPO ligands|Phenol ethers|Acetanilides|Chloroarenes |
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