| 词条 | Daledalin |
| 释义 |
| IUPAC_name = N-Methyl-3-(3-methyl-1-phenyl-2,3-dihydro-1H-indol-3-yl)propan-1-amine | image = Daledalin.svg | tradename = | pregnancy_category = | legal_status = | routes_of_administration = | bioavailability = | metabolism = | elimination_half-life = | excretion = | CAS_number = 22136-27-2 | CAS_supplemental = {{CAS|23226-37-1}} (tosylate) | ATC_prefix = None | ATC_suffix = | ChEMBL = 2110924 | PubChem = 31707 | ChemSpiderID = 29403 | UNII_Ref = {{fdacite|correct|FDA}} | UNII = IT56261A5A | C=19 | H=24 | N=2 | molecular_weight = 280.409 g/mol | smiles = c1cccc2c1C(C)(CN2c3ccccc3)CCCNC }}Daledalin (UK-3557-15) is an antidepressant which was synthesized and trialed for depression in the early 1970s, but was never marketed.[1][2][3] It is a selective norepinephrine reuptake inhibitor, with no significant effects on the reuptake of serotonin and dopamine, and no antihistamine or anticholinergic properties.[4][5] SynthesisSee also
References1. ^{{cite book | author = David J. Triggle | title = Dictionary of pharmacological agents | publisher = Chapman & Hall | location = London | year = 1997 | pages = | isbn = 978-0-412-46630-4 | oclc = | doi = | url = https://books.google.com/books?id=DeX7jgInYFMC&lpg=PA565&dq=daledalin&pg=PA565#v=onepage&q=daledalin&f=false}} {{Antidepressants}}{{Monoamine reuptake inhibitors}}{{nervous-system-drug-stub}}{{amine-stub}}2. ^{{cite journal | author = Canas-Rodriquez A, Leeming PR | title = N-Phenyl-2-indolinones and N-phenylindolines - New class of antidepressant agents | journal = Journal of Medicinal Chemistry | volume = 15 | issue = 7 | pages = 762–770 | year = 1972 | pmid = | doi = 10.1021/jm00277a017 }} 3. ^{{cite journal | author = Edwards JG, Ollerenshaw DP | title = Daledalin tosylate: a controlled trial in depressive illness | journal = Current Medical Research and Opinion | volume = 2 | issue = 6 | pages = 305–12 | year = 1974 | pmid = 4614944 | doi = 10.1185/03007997409114763 }} 4. ^{{cite journal | author = Canas-Rodriquez A, Leeming PR | title = N-Phenyl-2-indolinones and N-phenylindolines - New class of antidepressant agents | journal = Journal of Medicinal Chemistry | volume = 15 | issue = 7 | pages = 762–770 | year = 1972 | pmid = | doi = 10.1021/jm00277a017 }} 5. ^{{cite journal | author = Koe BK | title = Molecular geometry of inhibitors of the uptake of catecholamines and serotonin in synaptosomal preparations of rat brain | journal = Journal of Pharmacology and Experimental Therapeutics | volume = 199 | issue = 3 | pages = 649–661 |date=December 1976 | pmid = | doi = | url = http://jpet.aspetjournals.org/content/199/3/649.abstract}} 6. ^{{cite journal | doi = 10.1021/jm00277a017 | title=N-Phenyl-2-indolinones and N-phenylindolines. New class of antidepressant agents | journal=Journal of Medicinal Chemistry | date=1972 | volume=15 | issue=7 | pages=762–770 | first=A. | last=Canas-Rodriguez}} 5 : Abandoned drugs|Amines|Antidepressants|Indolines|Norepinephrine reuptake inhibitors |
| 随便看 |
|
开放百科全书收录14589846条英语、德语、日语等多语种百科知识，基本涵盖了大多数领域的百科知识，是一部内容自由、开放的电子版国际百科全书。