1. Function

2. Interactions

3. References

4. Further reading

Function

Death-associated protein kinase 3 (DAPK3) induces morphological changes in apoptosis when overexpressed in mammalian cells. These results suggest that DAPK3 may play a role in the induction of apoptosis.^[2]

Unlike most other mammalian genes, murine (rat and mouse) DAPK3 has undergone accelerated evolution and diverged from the tightly conserved consensus that is maintained from fish to human.^[3]

Interactions

DAPK3 has been shown to interact with PAWR^[4] and Death associated protein 6.^[4]

References

Further reading

• {{cite journal | vauthors = Saito T, Seki N, Ohira M, Hayashi A, Kozuma S, Hattori A, Hori T | title = Assignment of the ZIP kinase gene to human chromosome 19p13.3 by somatic hybrid analysis and fluorescence in-situ hybridization | journal = Journal of Human Genetics | volume = 43 | issue = 3 | pages = 209–11 | year = 1998 | pmid = 9747039 | doi = 10.1007/s100380050073 }}
• {{cite journal | vauthors = Murata-Hori M, Suizu F, Iwasaki T, Kikuchi A, Hosoya H | title = ZIP kinase identified as a novel myosin regulatory light chain kinase in HeLa cells | journal = FEBS Letters | volume = 451 | issue = 1 | pages = 81–4 | date = May 1999 | pmid = 10356987 | doi = 10.1016/S0014-5793(99)00550-5 }}
• {{cite journal | vauthors = Page G, Lödige I, Kögel D, Scheidtmann KH | title = AATF, a novel transcription factor that interacts with Dlk/ZIP kinase and interferes with apoptosis | journal = FEBS Letters | volume = 462 | issue = 1–2 | pages = 187–91 | date = Nov 1999 | pmid = 10580117 | doi = 10.1016/S0014-5793(99)01529-X }}
• {{cite journal | vauthors = Page G, Kögel D, Rangnekar V, Scheidtmann KH | title = Interaction partners of Dlk/ZIP kinase: co-expression of Dlk/ZIP kinase and Par-4 results in cytoplasmic retention and apoptosis | journal = Oncogene | volume = 18 | issue = 51 | pages = 7265–73 | date = Dec 1999 | pmid = 10602480 | doi = 10.1038/sj.onc.1203170 }}
• {{cite journal | vauthors = Cariou B, Perdereau D, Cailliau K, Browaeys-Poly E, Béréziat V, Vasseur-Cognet M, Girard J, Burnol AF | title = The adapter protein ZIP binds Grb14 and regulates its inhibitory action on insulin signaling by recruiting protein kinase Czeta | journal = Molecular and Cellular Biology | volume = 22 | issue = 20 | pages = 6959–70 | date = Oct 2002 | pmid = 12242277 | pmc = 139806 | doi = 10.1128/MCB.22.20.6959-6970.2002 }}
• {{cite journal | vauthors = Preuss U, Landsberg G, Scheidtmann KH | title = Novel mitosis-specific phosphorylation of histone H3 at Thr11 mediated by Dlk/ZIP kinase | journal = Nucleic Acids Research | volume = 31 | issue = 3 | pages = 878–85 | date = Feb 2003 | pmid = 12560483 | pmc = 149197 | doi = 10.1093/nar/gkg176 }}
• {{cite journal | vauthors = Kawai T, Akira S, Reed JC | title = ZIP kinase triggers apoptosis from nuclear PML oncogenic domains | journal = Molecular and Cellular Biology | volume = 23 | issue = 17 | pages = 6174–86 | date = Sep 2003 | pmid = 12917339 | pmc = 180930 | doi = 10.1128/MCB.23.17.6174-6186.2003 }}
• {{cite journal | vauthors = Burch LR, Scott M, Pohler E, Meek D, Hupp T | title = Phage-peptide display identifies the interferon-responsive, death-activated protein kinase family as a novel modifier of MDM2 and p21WAF1 | journal = Journal of Molecular Biology | volume = 337 | issue = 1 | pages = 115–28 | date = Mar 2004 | pmid = 15001356 | doi = 10.1016/j.jmb.2003.10.081 }}
• {{cite journal | vauthors = Endo A, Surks HK, Mochizuki S, Mochizuki N, Mendelsohn ME | title = Identification and characterization of zipper-interacting protein kinase as the unique vascular smooth muscle myosin phosphatase-associated kinase | journal = The Journal of Biological Chemistry | volume = 279 | issue = 40 | pages = 42055–61 | date = Oct 2004 | pmid = 15292222 | doi = 10.1074/jbc.M403676200 }}
• {{cite journal | vauthors = Schaaf CP, Benzing J, Schmitt T, Erz DH, Tewes M, Bartram CR, Janssen JW | title = Novel interaction partners of the TPR/MET tyrosine kinase | journal = FASEB Journal | volume = 19 | issue = 2 | pages = 267–9 | date = Feb 2005 | pmid = 15546961 | doi = 10.1096/fj.04-1558fje }}
• {{cite journal | vauthors = Yu H, Jiang D, Guo Z, Saiyin H, Guo J, Wang X, Yu L | title = TCP10L is expressed specifically in spermatogenic cells and binds to death associated protein kinase-3 | journal = International Journal of Andrology | volume = 28 | issue = 3 | pages = 163–70 | date = Jun 2005 | pmid = 15910542 | doi = 10.1111/j.1365-2605.2005.00522.x }}
• {{cite journal | vauthors = Shoval Y, Pietrokovski S, Kimchi A | title = ZIPK: a unique case of murine-specific divergence of a conserved vertebrate gene | journal = PLoS Genetics | volume = 3 | issue = 10 | pages = 1884–93 | date = Oct 2007 | pmid = 17953487 | pmc = 2041995 | doi = 10.1371/journal.pgen.0030180 }}
• {{cite journal | vauthors = Takamoto N, Komatsu S, Komaba S, Niiro N, Ikebe M | title = Novel ZIP kinase isoform lacks leucine zipper | journal = Archives of Biochemistry and Biophysics | volume = 456 | issue = 2 | pages = 194–203 | date = Dec 2006 | pmid = 17126281 | pmc = 2758612 | doi = 10.1016/j.abb.2006.09.026 }}

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