| 释义 |
- References
- Further reading
{{about|a human gene|the automobile|Aston Martin DBR1}}{{Underlinked|date=May 2016}}{{Infobox_gene}}Lariat debranching enzyme is a protein that in humans is encoded by the DBR1 gene.[1][2]The RNA lariat debranching enzyme, or DBR1, specifically hydrolyzes 2-prime-to-5-prime branched phosphodiester bonds at the branch point of excised lariat intron RNA and converts them into linear molecules.[supplied by OMIM][2] References1. ^{{cite journal | vauthors = Kim JW, Kim HC, Kim GM, Yang JM, Boeke JD, Nam K | title = Human RNA lariat debranching enzyme cDNA complements the phenotypes of Saccharomyces cerevisiae dbr1 and Schizosaccharomyces pombe dbr1 mutants | journal = Nucleic Acids Res | volume = 28 | issue = 18 | pages = 3666–73 |date=Sep 2000 | pmid = 10982890 | pmc = 110720 | doi =10.1093/nar/28.18.3666 }}
2. ^1 {{cite web | title = Entrez Gene: DBR1 debranching enzyme homolog 1 (S. cerevisiae)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51163| accessdate = }}
Further reading{{refbegin | 2}}- {{cite journal | vauthors=Chapman KB, Boeke JD |title=Isolation and characterization of the gene encoding yeast debranching enzyme. |journal=Cell |volume=65 |issue= 3 |pages= 483–92 |year= 1991 |pmid= 1850323 |doi=10.1016/0092-8674(91)90466-C }}
- {{cite journal | vauthors=Arenas J, Hurwitz J |title=Purification of a RNA debranching activity from HeLa cells. |journal=J. Biol. Chem. |volume=262 |issue= 9 |pages= 4274–9 |year= 1987 |pmid= 2435736 |doi= }}
- {{cite journal | vauthors=Martin A, Schneider S, Schwer B |title=Prp43 is an essential RNA-dependent ATPase required for release of lariat-intron from the spliceosome. |journal=J. Biol. Chem. |volume=277 |issue= 20 |pages= 17743–50 |year= 2002 |pmid= 11886864 |doi= 10.1074/jbc.M200762200 }}
- {{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
- {{cite journal | vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal}}
- {{cite journal | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
- {{cite journal | vauthors=Ye Y, De Leon J, Yokoyama N |title=DBR1 siRNA inhibition of HIV-1 replication. |journal=Retrovirology |volume=2 |issue= |pages= 63 |year= 2006 |pmid= 16232320 |doi= 10.1186/1742-4690-2-63 | pmc=1266399 |display-authors=etal}}
- {{cite journal | vauthors=Olsen JV, Blagoev B, Gnad F |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 |display-authors=etal}}
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