| 词条 | DCG-IV |
| 释义 |
| Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 424938787 | IUPAC_name = (1R,2R)-3-[(1S)-1-amino-2-hydroxy-2-oxoethyl]cyclopropane-1,2-dicarboxylic acid | image = DCGIV_structure.png | width = 200 | tradename = | pregnancy_AU = | pregnancy_US = | pregnancy_category = | legal_AU = | legal_CA = | legal_UK = | legal_US = | legal_status = | routes_of_administration = | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion = | CAS_number_Ref = {{cascite|correct|??}} | CAS_number = 147782-19-2 | ATC_prefix = | ATC_suffix = | PubChem = 5310979 | DrugBank = | ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}} | ChemSpiderID = 4470521 | C=7 | H=9 | N=1 | O=6 | molecular_weight = 203.149 g/mol | smiles = [C@@H]1([C@@H](C1[C@@H](C(=O)O)N)C(=O)O)C(=O)O | StdInChI_Ref = {{stdinchicite|changed|chemspider}} | StdInChI = 1S/C7H9NO6/c8-4(7(13)14)1-2(5(9)10)3(1)6(11)12/h1-4H,8H2,(H,9,10)(H,11,12)(H,13,14)/t2-,3-,4+/m1/s1 | StdInChIKey_Ref = {{stdinchicite|changed|chemspider}} | StdInChIKey = MATPZHBYOVDBLI-JJYYJPOSSA-N }}DCG-IV is a research drug which acts as a group-selective agonist for the group II metabotropic glutamate receptors (mGluR2/3).[1] It has potent neuroprotective and anticonvulsant effects in animal studies,[2][3][4][5] as well as showing anti-Parkinsonian effects,[6][7] but also impairs the formation of memories.[8][9] References1. ^{{cite journal |vauthors=Ishida M, Saitoh T, Shimamoto K, Ohfune Y, Shinozaki H |title=A novel metabotropic glutamate receptor agonist: marked depression of monosynaptic excitation in the newborn rat isolated spinal cord |journal=British Journal of Pharmacology |volume=109 |issue=4 |pages=1169–77 |date=August 1993 |pmid=8401927 |pmc=2175774 |doi= 10.1111/j.1476-5381.1993.tb13745.x|url=}} {{Metabotropic glutamate receptor modulators}}{{anticonvulsant-stub}}2. ^{{cite journal |vauthors=Bruno V, Copani A, Battaglia G, Raffaele R, Shinozaki H, Nicoletti F |title=Protective effect of the metabotropic glutamate receptor agonist, DCG-IV, against excitotoxic neuronal death |journal=European Journal of Pharmacology |volume=256 |issue=1 |pages=109–12 |date=April 1994 |pmid=7517889 |doi= 10.1016/0014-2999(94)90624-6|url=}} 3. ^{{cite journal |vauthors=Yoshioka H, Sugita M, Kinouchi H |title=Neuroprotective effects of group II metabotropic glutamate receptor agonist DCG-IV on hippocampal neurons in transient forebrain ischemia |journal=Neuroscience Letters |volume=461 |issue=3 |pages=266–70 |date=September 2009 |pmid=19549561 |doi=10.1016/j.neulet.2009.06.056 |url=}} 4. ^{{cite journal |vauthors=Attwell PJ, Singh Kent N, Jane DE, Croucher MJ, Bradford HF |title=Anticonvulsant and glutamate release-inhibiting properties of the highly potent metabotropic glutamate receptor agonist (2S,2'R, 3'R)-2-(2',3'-dicarboxycyclopropyl)glycine (DCG-IV) |journal=Brain Research |volume=805 |issue=1-2 |pages=138–43 |date=September 1998 |pmid=9733953 |doi= 10.1016/S0006-8993(98)00698-2|url=}} 5. ^{{cite journal |vauthors=Fei Z, Zhang X, Bai HM, Jiang XF, Wang XL |title=Metabotropic glutamate receptor antagonists and agonists: potential neuroprotectors in diffuse brain injury |journal=Journal of Clinical Neuroscience |volume=13 |issue=10 |pages=1023–7 |date=December 2006 |pmid=17113985 |doi=10.1016/j.jocn.2005.11.042 |url=}} 6. ^{{cite journal |vauthors=Dawson L, Chadha A, Megalou M, Duty S |title=The group II metabotropic glutamate receptor agonist, DCG-IV, alleviates akinesia following intranigral or intraventricular administration in the reserpine-treated rat |journal=British Journal of Pharmacology |volume=129 |issue=3 |pages=541–6 |date=February 2000 |pmid=10711353 |pmc=1571875 |doi=10.1038/sj.bjp.0703105 |url=}} 7. ^{{cite journal |vauthors=Venero JL, Santiago M, Tomás-Camardiel M, Matarredona ER, Cano J, Machado A |title=DCG-IV but not other group-II metabotropic receptor agonists induces microglial BDNF mRNA expression in the rat striatum. Correlation with neuronal injury |journal=Neuroscience |volume=113 |issue=4 |pages=857–69 |year=2002 |pmid=12182892 |doi= 10.1016/S0306-4522(02)00232-4|url=}} 8. ^{{cite journal |vauthors=Huang LQ, Rowan MJ, Anwyl R |title=mGluR II agonist inhibition of LTP induction, and mGluR II antagonist inhibition of LTD. induction, in the dentate gyrus in vitro |journal=NeuroReport |volume=8 |issue=3 |pages=687–93 |date=February 1997 |pmid=9106748 |doi= 10.1097/00001756-199702100-00022|url=}} 9. ^{{cite journal |vauthors=Sato T, Tanaka K, Ohnishi Y, Teramoto T, Irifune M, Nishikawa T |title=Inhibitory effects of group II mGluR-related drugs on memory performance in mice |journal=Physiology & Behavior |volume=80 |issue=5 |pages=747–58 |date=February 2004 |pmid=14984810 |doi=10.1016/j.physbeh.2003.12.010 |url=}} 6 : Anticonvulsants|Amino acids|Tricarboxylic acids|Cyclopropanes|MGlu2 receptor agonists|MGlu3 receptor agonists |
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