“DCP2”的意思、由来-开放百科全书

　

词条

DCP2

释义

Interactions
References
Further reading

{{about|the gene and encoded protein|the Disease Control Priorities in Developing Countries Report (2nd edition)|Disease Control Priorities Project}}{{Infobox_gene}}mRNA-decapping enzyme 2 is a protein that in humans is encoded by the DCP2 gene.^[1]^[2]^[3]

DCP2 is a key component of an mRNA-decapping complex required for removal of the 5-prime cap from mRNA prior to its degradation from the 5-prime end (Fenger-Gron et al., 2005).[supplied by OMIM]^[3]

Interactions

DCP2 has been shown to interact with DCP1A^[4] and UPF1.^[2]^[5]

References

1. ^{{cite journal | vauthors = Wang Z, Jiao X, Carr-Schmid A, Kiledjian M | title = The hDcp2 protein is a mammalian mRNA decapping enzyme pro-caratine| journal = Proc Natl Acad Sci U S A | volume = 99 | issue = 20 | pages = 12663–8 |date=Oct 2002 | pmid = 12218187 | pmc = 130517 | doi = 10.1073/pnas.192445599 | bibcode = 2002PNAS...9912663W }}
2. ^¹{{cite journal | author = Lykke-Andersen J | title = Identification of a human decapping complex associated with hUpf proteins in nonsense-mediated decay | journal = Mol Cell Biol | volume = 22 | issue = 23 | pages = 8114–21 |date=Nov 2002 | pmid = 12417715 | pmc = 134073 | doi =10.1128/MCB.22.23.8114-8121.2002 }}
3. ^¹{{cite web | title = Entrez Gene: DCP2 DCP2 decapping enzyme homolog (S. cerevisiae)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=167227| accessdate = }}
4. ^{{cite journal |doi=10.1128/MCB.22.23.8114-8121.2002 |last=Lykke-Andersen |first=Jens |date=Dec 2002 |title=Identification of a human decapping complex associated with hUpf proteins in nonsense-mediated decay |journal=Mol. Cell. Biol. |volume=22 |issue=23 |pages=8114–21 | issn = 0270-7306| pmid = 12417715 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=134073 }}
5. ^{{cite journal |doi=10.1016/S1097-2765(03)00349-6 |last=Lejeune |first=Fabrice |author2=Li Xiaojie |author3=Maquat Lynne E |date=Sep 2003 |title=Nonsense-mediated mRNA decay in mammalian cells involves decapping, deadenylating, and exonucleolytic activities |journal=Mol. Cell |volume=12 |issue=3 |pages=675–87 | issn = 1097-2765| pmid = 14527413 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}

Further reading

{{refbegin | 2}}

{{cite journal | vauthors=Ueno K, Kumagai T, Kijima T |title=Cloning and tissue expression of cDNAs from chromosome 5q21-22 which is frequently deleted in advanced lung cancer. |journal=Hum. Genet. |volume=102 |issue= 1 |pages= 63–8 |year= 1998 |pmid= 9490301 |doi=10.1007/s004390050655 |display-authors=etal}}
{{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal|bibcode=2002PNAS...9916899M }}
{{cite journal | vauthors=van Dijk E, Cougot N, Meyer S |title=Human Dcp2: a catalytically active mRNA decapping enzyme located in specific cytoplasmic structures. |journal=EMBO J. |volume=21 |issue= 24 |pages= 6915–24 |year= 2004 |pmid= 12486012 |doi=10.1093/emboj/cdf678 | pmc=139098 |display-authors=etal}}
{{cite journal | vauthors=Ingelfinger D, Arndt-Jovin DJ, Lührmann R, Achsel T |title=The human LSm1-7 proteins colocalize with the mRNA-degrading enzymes Dcp1/2 and Xrnl in distinct cytoplasmic foci. |journal=RNA |volume=8 |issue= 12 |pages= 1489–501 |year= 2003 |pmid= 12515382 |doi= 10.1017/S1355838202021726| pmc=1370355 |doi-broken-date=2019-02-22 }}
{{cite journal | author=Grzymski EC |title=Visualizing an mRNA destruction line. |journal=Nat. Struct. Biol. |volume=10 |issue= 6 |pages= 416 |year= 2003 |pmid= 12768200 |doi= 10.1038/nsb0603-416 }}
{{cite journal | vauthors=Piccirillo C, Khanna R, Kiledjian M |title=Functional characterization of the mammalian mRNA decapping enzyme hDcp2. |journal=RNA |volume=9 |issue= 9 |pages= 1138–47 |year= 2003 |pmid= 12923261 |doi=10.1261/rna.5690503 | pmc=1370477 }}
{{cite journal | vauthors=Lejeune F, Li X, Maquat LE |title=Nonsense-mediated mRNA decay in mammalian cells involves decapping, deadenylating, and exonucleolytic activities. |journal=Mol. Cell |volume=12 |issue= 3 |pages= 675–87 |year= 2003 |pmid= 14527413 |doi=10.1016/S1097-2765(03)00349-6 }}
{{cite journal | vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal}}
{{cite journal | vauthors=Cougot N, Babajko S, Séraphin B |title=Cytoplasmic foci are sites of mRNA decay in human cells. |journal=J. Cell Biol. |volume=165 |issue= 1 |pages= 31–40 |year= 2004 |pmid= 15067023 |doi= 10.1083/jcb.200309008 | pmc=2172085 }}
{{cite journal | vauthors=Lehner B, Sanderson CM |title=A protein interaction framework for human mRNA degradation. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1315–23 |year= 2004 |pmid= 15231747 |doi= 10.1101/gr.2122004 | pmc=442147 }}
{{cite journal | vauthors=Liu SW, Jiao X, Liu H |title=Functional analysis of mRNA scavenger decapping enzymes. |journal=RNA |volume=10 |issue= 9 |pages= 1412–22 |year= 2004 |pmid= 15273322 |doi= 10.1261/rna.7660804 | pmc=1370627 |display-authors=etal}}
{{cite journal | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
{{cite journal | vauthors=Liu J, Valencia-Sanchez MA, Hannon GJ, Parker R |title=MicroRNA-dependent localization of targeted mRNAs to mammalian P-bodies. |journal=Nat. Cell Biol. |volume=7 |issue= 7 |pages= 719–23 |year= 2005 |pmid= 15937477 |doi= 10.1038/ncb1274 | pmc=1855297 }}
{{cite journal | vauthors=Fenger-Grøn M, Fillman C, Norrild B, Lykke-Andersen J |title=Multiple processing body factors and the ARE binding protein TTP activate mRNA decapping. |journal=Mol. Cell |volume=20 |issue= 6 |pages= 905–15 |year= 2006 |pmid= 16364915 |doi= 10.1016/j.molcel.2005.10.031 }}
{{cite journal | vauthors=Wichroski MJ, Robb GB, Rana TM |title=Human retroviral host restriction factors APOBEC3G and APOBEC3F localize to mRNA processing bodies. |journal=PLoS Pathog. |volume=2 |issue= 5 |pages= e41 |year= 2006 |pmid= 16699599 |doi= 10.1371/journal.ppat.0020041 | pmc=1458959 }}
{{cite journal | vauthors=Chu CY, Rana TM |title=Translation repression in human cells by microRNA-induced gene silencing requires RCK/p54. |journal=PLoS Biol. |volume=4 |issue= 7 |pages= e210 |year= 2006 |pmid= 16756390 |doi= 10.1371/journal.pbio.0040210 | pmc=1475773 }}
{{cite journal | vauthors=Olsen JV, Blagoev B, Gnad F |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 |display-authors=etal}}

{{refend}}{{Post transcriptional modification}}{{gene-5-stub}}

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