| 词条 | DCPG |
| 释义 |
| Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 451225984 | IUPAC_name = 4-[(1S)-1-amino-2-hydroxy-2-oxoethyl]phthalic acid | image = DCPG_structure.png | width = 200 | tradename = | pregnancy_AU = | pregnancy_US = | pregnancy_category = | legal_AU = | legal_CA = | legal_UK = | legal_US = | legal_status = | routes_of_administration = | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion = | CAS_number_Ref = {{cascite|correct|??}} | CAS_number = 201730-11-2 | ATC_prefix = | ATC_suffix = | PubChem = 16062593 | IUPHAR_ligand = 1407 | DrugBank_Ref = {{drugbankcite|correct|drugbank}} | DrugBank = | ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}} | ChemSpiderID = 17222214 | smiles = O=C(O)[C@@H](N)c1cc(c(C(=O)O)cc1)C(=O)O | StdInChI_Ref = {{stdinchicite|changed|chemspider}} | StdInChI = 1S/C10H9NO6/c11-7(10(16)17)4-1-2-5(8(12)13)6(3-4)9(14)15/h1-3,7H,11H2,(H,12,13)(H,14,15)(H,16,17)/t7-/m0/s1 | StdInChIKey_Ref = {{stdinchicite|changed|chemspider}} | StdInChIKey = IJVMOGKBEVRBPP-ZETCQYMHSA-N | C=10 | H=9 | N=1 | O=6 | molecular_weight = 239.181 g/mol }}DCPG ((S)-3,4-DCPG) is a drug used in scientific research, which acts as a potent and subtype-selective agonist for the metabotropic glutamate receptor mGluR8. It has anticonvulsant effects in animal studies,[1][2] and has also been investigated as a possible treatment for hyperalgesia.[3] References1. ^Moldrich RX, Chapman AG, De Sarro G, Meldrum BS. Glutamate metabotropic receptors as targets for drug therapy in epilepsy. European Journal of Pharmacology. 2003 Aug 22;476(1-2):3-16. {{DOI|10.1016/S0014-2999(03)02149-6}} {{PMID|12969743}} {{Metabotropic glutamate receptor modulators}}{{anticonvulsant-stub}}2. ^Folbergrová J, Druga R, Haugvicová R, Mares P, Otáhal J. Anticonvulsant and neuroprotective effect of (S)-3,4-dicarboxyphenylglycine against seizures induced in immature rats by homocysteic acid. Neuropharmacology. 2008 Mar;54(4):665-75. {{PMID|18191956}} 3. ^Marabese I, de Novellis V, Palazzo E, Scafuro MA, Vita D, Rossi F, Maione S. Effects of (S)-3,4-DCPG, an mGlu8 receptor agonist, on inflammatory and neuropathic pain in mice. Neuropharmacology. 2007 Feb;52(2):253-62. {{PMID|17113112}} 4 : Anticonvulsants|Amino acid derivatives|Tricarboxylic acids|MGlu8 receptor agonists |
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