“DCPS (gene)”的意思、由来-开放百科全书

The scavenger mRNA decapping enzymes include Dcp2 and DcpS. DcpS is a scavenger pyrophosphatase that hydrolyses the residual cap structure following 3' to 5' mRNA degradation. DcpS uses cap dinucleotides or capped oligonucleotides as substrates to release m(7)GMP (N7-methyl GMP), while Dcp2 uses capped mRNA as a substrate in order to hydrolyse the cap to release m(7)GDP (N7-methyl GDP).^[4] The association of DcpS with 3' to 5' exonuclease exosome components suggests that these two activities are linked and there is a coupled exonucleolytic decay-dependent decapping pathway. The family contains a histidine triad (HIT) sequence in its C-terminal domain, with three histidines separated by hydrophobic residues.^[5] The central histidine within the DcpS HIT motif is critical for decapping activity and defines the HIT motif as a new mRNA decapping domain, making DcpS the first member of the HIT family of proteins with a defined biological function.

References

1. ^{{cite journal | vauthors = Liu H, Rodgers ND, Jiao X, Kiledjian M | title = The scavenger mRNA decapping enzyme DcpS is a member of the HIT family of pyrophosphatases | journal = EMBO J | volume = 21 | issue = 17 | pages = 4699–4708 |date=Aug 2002 | pmid = 12198172 | pmc = 126188 | doi =10.1093/emboj/cdf448 }}
2. ^{{cite journal | vauthors = van Dijk E, Le Hir H, Seraphin B | title = DcpS can act in the 5'-3' mRNA decay pathway in addition to the 3'-5' pathway | journal = Proc Natl Acad Sci U S A | volume = 100 | issue = 21 | pages = 12081–12086 |date=Oct 2003 | pmid = 14523240 | pmc = 218716 | doi = 10.1073/pnas.1635192100 }}
3. ^{{cite web | title = Entrez Gene: DCPS decapping enzyme, scavenger| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=28960| accessdate = }}
4. ^{{cite journal | vauthors = Liu H, Kiledjian M | title = Decapping the message: a beginning or an end | journal = Biochem. Soc. Trans. | volume = 34 | issue = Pt 1 | pages = 35–8 |date=February 2006 | pmid = 16246173 | doi = 10.1042/BST20060035 | url = }}
5. ^{{cite journal | vauthors = Han GW, Schwarzenbacher R, McMullan D, Abdubek P, Ambing E, Axelrod H, Biorac T, Canaves JM, Chiu HJ, Dai X, Deacon AM, DiDonato M, Elsliger MA, Godzik A, Grittini C, Grzechnik SK, Hale J, Hampton E, Haugen J, Hornsby M, Jaroszewski L, Klock HE, Koesema E, Kreusch A, Kuhn P, Lesley SA, McPhillips TM, Miller MD, Moy K, Nigoghossian E, Paulsen J, Quijano K, Reyes R, Spraggon G, Stevens RC, van den Bedem H, Velasquez J, Vincent J, White A, Wolf G, Xu Q, Hodgson KO, Wooley J, Wilson IA | title = Crystal structure of an Apo mRNA decapping enzyme (DcpS) from Mouse at 1.83 A resolution | journal = Proteins | volume = 60 | issue = 4 | pages = 797–802 |date=September 2005 | pmid = 16001405 | doi = 10.1002/prot.20467 | url = }}

Further reading

{{cite journal | vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides |journal=Gene |volume=138 |issue= 1–2 |pages= 171–174 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}

{{cite journal | author=Suzuki Y |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–156 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 |name-list-format=vanc| author2=Yoshitomo-Nakagawa K | author3=Maruyama K | display-authors=3 | last4=Suyama | first4=A | last5=Sugano | first5=S }}

{{cite journal | author=Zhang QH |title=Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells |journal=Genome Res. |volume=10 |issue= 10 |pages= 1546–1560 |year= 2001 |pmid= 11042152 |doi=10.1101/gr.140200 | pmc=310934 |name-list-format=vanc| author2=Ye M | author3=Wu XY | display-authors=3 | last4=Ren | first4=SX | last5=Zhao | first5=M | last6=Zhao | first6=CJ | last7=Fu | first7=G | last8=Shen | first8=Y | last9=Fan | first9=HY }}

{{cite journal | vauthors=Wang Z, Kiledjian M |title=Functional link between the mammalian exosome and mRNA decapping |journal=Cell |volume=107 |issue= 6 |pages= 751–762 |year= 2002 |pmid= 11747811 |doi=10.1016/S0092-8674(01)00592-X }}

{{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–16903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |name-list-format=vanc| author2=Feingold EA | author3=Grouse LH | display-authors=3 | last4=Derge | first4=JG | last5=Klausner | first5=RD | last6=Collins | first6=FS | last7=Wagner | first7=L | last8=Shenmen | first8=CM | last9=Schuler | first9=GD }}

{{cite journal | author=Kwasnicka DA |title=Coordinate expression of NADPH-dependent flavin reductase, Fre-1, and Hint-related 7meGMP-directed hydrolase, DCS-1 |journal=J. Biol. Chem. |volume=278 |issue= 40 |pages= 39051–39058 |year= 2003 |pmid= 12871939 |doi= 10.1074/jbc.M306355200 | pmc=2556063 |name-list-format=vanc| author2=Krakowiak A | author3=Thacker C | display-authors=3 | last4=Brenner | first4=C | last5=Vincent | first5=SR }}

{{cite journal | author=Ota T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–45 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |name-list-format=vanc| author2=Suzuki Y | author3=Nishikawa T | display-authors=3 | last4=Otsuki | first4=Tetsuji | last5=Sugiyama | first5=Tomoyasu | last6=Irie | first6=Ryotaro | last7=Wakamatsu | first7=Ai | last8=Hayashi | first8=Koji | last9=Sato | first9=Hiroyuki }}

{{cite journal | author=Gu M |title=Insights into the structure, mechanism, and regulation of scavenger mRNA decapping activity |journal=Mol. Cell |volume=14 |issue= 1 |pages= 67–80 |year= 2004 |pmid= 15068804 |doi=10.1016/S1097-2765(04)00180-7 |name-list-format=vanc| author2=Fabrega C | author3=Liu SW | display-authors=3 | last4=Liu | first4=Hudan | last5=Kiledjian | first5=Megerditch | last6=Lima | first6=Christopher D }}

{{cite journal | author=Liu SW |title=Functional analysis of mRNA scavenger decapping enzymes |journal=RNA |volume=10 |issue= 9 |pages= 1412–1422 |year= 2004 |pmid= 15273322 |doi= 10.1261/rna.7660804 | pmc=1370627 |name-list-format=vanc| author2=Jiao X | author3=Liu H | display-authors=3 | last4=Gu | first4=M | last5=Lima | first5=CD | last6=Kiledjian | first6=M }}

{{cite journal | author=Gerhard DS |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–2127 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |name-list-format=vanc| author2=Wagner L | author3=Feingold EA | display-authors=3 | last4=Shenmen | first4=CM | last5=Grouse | first5=LH | last6=Schuler | first6=G | last7=Klein | first7=SL | last8=Old | first8=S | last9=Rasooly | first9=R }}

{{cite journal | vauthors=Malys N, Carroll K, Miyan J, Tollervey D, McCarthy JE |title=The 'scavenger' m7GpppX pyrophosphatase activity of Dcs1 modulates nutrient-induced responses in yeast |journal=Nucleic Acids Res. |volume=32 |issue= 12 |pages= 3590–3600 |year= 2004 |pmid= 15240832 |doi= 10.1093/nar/gkh687 | pmc=484174 }}

{{cite journal | author=Chen N |title=Crystal structures of human DcpS in ligand-free and m7GDP-bound forms suggest a dynamic mechanism for scavenger mRNA decapping |journal=J. Mol. Biol. |volume=347 |issue= 4 |pages= 707–718 |year= 2005 |pmid= 15769464 |doi= 10.1016/j.jmb.2005.01.062 |name-list-format=vanc| author2=Walsh MA | author3=Liu Y | display-authors=3 | last4=Parker | first4=Roy | last5=Song | first5=Haiwei }}

{{cite journal | vauthors=Kwaśnicka-Crawford DA, Vincent SR |title=Role of a novel dual flavin reductase (NR1) and an associated histidine triad protein (DCS-1) in menadione-induced cytotoxicity |journal=Biochem. Biophys. Res. Commun. |volume=336 |issue= 2 |pages= 565–571 |year= 2005 |pmid= 16140270 |doi= 10.1016/j.bbrc.2005.08.129 }}

{{cite journal | vauthors=Malys N, ((McCarthy JEG)) |title=Dcs2, a novel stress-induced modulator of m7GpppX pyrophosphatase activity that locates to P bodies |journal=J. Mol. Biol. |volume=363 |issue= 2 |pages= 370–382 |year= 2006 |pmid= 16963086 |doi= 10.1016/j.jmb.2006.08.015 }}

1 : Protein families

References

See also

Further reading