“DCTP deaminase”的意思、由来-开放百科全书

词条

DCTP deaminase

释义

Structural studies
References

{{enzyme
| Name = dCTP deaminase
| EC_number = 3.5.4.13
| CAS_number = 37289-18-2
| IUBMB_EC_number = 3/5/4/13
| GO_code = 0008829
| image =
| width =
| caption =
}}{{lowercase}}

In enzymology, a dCTP deaminase ({{EC number|3.5.4.13}}) is an enzyme that catalyzes the chemical reaction

dCTP + H₂O dUTP + NH₃

Thus, the two substrates of this enzyme are dCTP and H₂O, whereas its two products are dUTP and NH₃.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in cyclic amidines. The systematic name of this enzyme class is dCTP aminohydrolase. Other names in common use include deoxycytidine triphosphate deaminase, and 5-methyl-dCTP deaminase. This enzyme participates in pyrimidine metabolism.

Structural studies

As of late 2007, 9 structures have been solved for this class of enzymes, with PDB accession codes {{PDB link|1OGH}}, {{PDB link|1PKH}}, {{PDB link|1PKJ}}, {{PDB link|1PKK}}, {{PDB link|1XS1}}, {{PDB link|1XS4}}, {{PDB link|1XS6}}, {{PDB link|2J4H}}, and {{PDB link|2J4Q}}.

References

{{cite journal |vauthors=Tomita F, Takahashi I | date = 1969 | title = A novel enzyme, dCTP deaminase, found in Bacillus subtilis infected with phage PBS I | journal = Biochim. Biophys. Acta | volume = 179 | pages = 18–27 | pmid = 4976547 | issue = 1 | doi=10.1016/0005-2787(69)90117-8}}

{{Carbon-nitrogen non-peptide hydrolases}}{{Enzymes}}{{Portal bar|Molecular and Cellular Biology|border=no}}{{3.5-enzyme-stub}}

2 : EC 3.5.4|Enzymes of known structure

随便看

开放百科全书收录14589846条英语、德语、日语等多语种百科知识，基本涵盖了大多数领域的百科知识，是一部内容自由、开放的电子版国际百科全书。